TY  - JOUR
TI  - Effects of Captopril and Ketotifen on Protecting Against Renal Scarring Due to Pyelonephritis Injury
AB  - Objective: Increased levels of Angiotensin II (Ang II) are responsible for the development of hypertension and diabetesinduced nephropathy. In addition, the preventability of renal fibrosis with Ang II blockade is a known entity. Althoughmast cells are not present in normal kidney, increased mast cell density in the specimens examined for fibrosis hasattracted attention and it is thought that fibrotic agents released from these cells and may contribute to the process.Therefore, an experimental study was planned to decrease the ang II levels with captopril, an angiotensin convertingenzyme (ACE) inhibitor and to prevent the development of renal scarring due to pyelonephritis using ketotifen, a mastcell stabilizer.Material and Methods: Fifty rats were divided into five equal groups. In Group A, the renal cortex was injected withSF. In Group B, acute pyelonephritis was induced by 107 E. coli injections into the renal cortex. Group C receivedantibiotic treatment with E. coli injection, Group D received antibiotic and captopril with E. coli injection, Group E.received antibiotic and ketotifen with E. coli injection. In order to represent the chronic process, rats were sacrificed after6 weeks, and the contralateral kidney was included in pathological examination and statistical evaluation.Results: Inflammatory scores were significantly higher in group B compared to group A (p = 0.001). Captopril orketotifen treatment were the only factors that reduced scar development (p = 0.007). However, when captopril orketotifen treatments were compared in preventing scar development, no superiority was found (p> 0.05).Conclusion: We found that captopril and ketotifen has a protective effect in the development of renal fibrosis in a ratmodel of acute pyelonephritis. We believe that our study may contribute to clinical trials in the prevention of renal scardevelopment.
AU  - KARAKUŞ, ESRA
AU  - azili, mujdem nur
AU  - Şenaylı, Atilla
AU  - Tiryaki, Tugrul
DO  - 10.12956/tchd.592543
PY  - 2019
JO  - Türkiye Çocuk Hastalıkları Dergisi
VL  - 13
IS  - 6
SN  - 1307-4490
SP  - 475
EP  - 480
DB  - TRDizin
UR  - http://search/yayin/detay/426950
ER  -