Investigation of Momordica Charantia Effects on Foot Inflammation Model in Rats and Behavioral Changes Due to This Inflammation; Experimental Model. Investigation of the Effects of Momordica Charantia
Yıl: 2021 Cilt: 6 Sayı: 1 Sayfa Aralığı: 112 - 119 Metin Dili: İngilizce DOI: 10.35229/jaes.835178 İndeks Tarihi: 25-06-2021
Investigation of Momordica Charantia Effects on Foot Inflammation Model in Rats and Behavioral Changes Due to This Inflammation; Experimental Model. Investigation of the Effects of Momordica Charantia
Öz: Pain is an unpleasant sensation originating from any part of the body, associated withactual or possible tissue damage, and linked to past human experiences. Momordica Charantia(MC) or bitter melon mainly is used all around the world for the treatment of diabetes, cancer andinflammation- associated conditions due to the existence of many bioactive ingredients whichhave vigorous biologic effect. The aim of our study is to investigate how low and high doses ofMC plant affect foot inflammation and animal's behavior. Sixteen male rats randomly dividedinto 4 experimental groups. Formaldehyde was (hind-paw formalin injection) administered forinducing pain model. After 24 hours MC (50 mg/kg, 200 mg/kg) was administered every day forfive days. During the experiment, the pain thresholds, locomotor activity measurements andinflamed foot volume, Locomotor Activity Test and Water Overflow Method in sequence.According to our result, when we consider the foot volume, pain threshold and locomotor activitydata of our control group, there is no significant difference between the beginning and the lastday, on the 7th day, the pain threshold continues to decrease as the foot volume of our animals inour positive control group does not decrease. 200 mg concentration of MC has provided a greattreatment by reducing the increasing foot volume at the same time pain threshold and motoractivity was in highest level at 4th day.Our experiment shows that MC (200 mg/ml MC) has high analgesic activity provides significantpain reduction and improvement in symptoms.
Anahtar Kelime: Momordica Charantia'nın Ratlarda Oluşturulan Ayak İnflamasyon Modeli ve Buna Bağlı Olarak Gelişen Davranış Değişiklikleri Üzerine Etkilerinin İncelenmesi
Öz: Ağrı, vücudun herhangi bir yerinden kaynaklanan, gerçek veya olası doku hasarı ile ilişkilendirilen ve insanın geçmiş deneyimleriyle bağlantılı hoş olmayan bir histir. Momordica charantia (MC), güçlü biyolojik etkiye sahip birçok biyoaktif bileşenin varlığından dolayı, tüm dünyada başlıca diyabet, kanser ve iltihap ile ilişkili durumların tedavisinde kullanılmaktadır. Çalışmamızın amacı, MC bitkisinin düşük ve yüksek dozlarının ayak iltihabını ve hayvanın davranışını nasıl etkilediğini araştırmaktır. On altı erkek sıçan rastgele seçilerek 4 deney grubuna ayrılmıştır. Ağrı modelini indüklemek için formaldehit (arka pençe formalin enjeksiyonu) uygulanmış ve Formaldehit uygulanmasından 24 saat sonra beş gün boyunca her gün MC (50 mg / kg, 200 mg / kg)uygulanmıştır. Deney sırasında ağrı eşikleri, lokomotor aktivite ölçümleri ve iltihaplı ayak hacmi, Lokomotor Aktivite Testi ve Su Taşma Yöntemi testleri çalışılmıştır. Sonucumuza göre, kontrol grubumuzun ayak hacmi, ağrı eşiği ve lokomotor aktivite verilerini göz önüne aldığımızda başlangıç ile son gün arasında anlamlı bir farklılık gözlenmemiştir.7. günde ağrı eşiği düşmeye devam ederken Pozitif kontrol grubumuzdaki hayvanlarımızın ayak hacminde azalma görülmemiştir. 200 mg MC konsantrasyonu artan ayak hacmini azaltmasının yanı sıra ağrı eşiğini de azaltarak harika bir tedavi sağlamıştır. Bunların yanı sıra lokomotor aktivitenin ise 4. günde en yüksek seviyede olduğu tespit edilmiştir. Deneyimizin sonucuna göre MC'nin (200 mg / ml MC) yüksek analjezik aktiviteye sahip olduğunu, belirgin ağrı azalması ve semptomlarda iyileşme sağladığını göstermektedir.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | Türkmen A, TAGHİZADEHGHALEHJOUGHİ A, Mohammadzadeh Akın D, Genç S, Hacimuftuoglu A (2021). Investigation of Momordica Charantia Effects on Foot Inflammation Model in Rats and Behavioral Changes Due to This Inflammation; Experimental Model. Investigation of the Effects of Momordica Charantia. , 112 - 119. 10.35229/jaes.835178 |
| Chicago | Türkmen Aybike,TAGHİZADEHGHALEHJOUGHİ Ali,Mohammadzadeh Akın Dr.Maryam,Genç Sıdıka,Hacimuftuoglu Ahmet Investigation of Momordica Charantia Effects on Foot Inflammation Model in Rats and Behavioral Changes Due to This Inflammation; Experimental Model. Investigation of the Effects of Momordica Charantia. (2021): 112 - 119. 10.35229/jaes.835178 |
| MLA | Türkmen Aybike,TAGHİZADEHGHALEHJOUGHİ Ali,Mohammadzadeh Akın Dr.Maryam,Genç Sıdıka,Hacimuftuoglu Ahmet Investigation of Momordica Charantia Effects on Foot Inflammation Model in Rats and Behavioral Changes Due to This Inflammation; Experimental Model. Investigation of the Effects of Momordica Charantia. , 2021, ss.112 - 119. 10.35229/jaes.835178 |
| AMA | Türkmen A,TAGHİZADEHGHALEHJOUGHİ A,Mohammadzadeh Akın D,Genç S,Hacimuftuoglu A Investigation of Momordica Charantia Effects on Foot Inflammation Model in Rats and Behavioral Changes Due to This Inflammation; Experimental Model. Investigation of the Effects of Momordica Charantia. . 2021; 112 - 119. 10.35229/jaes.835178 |
| Vancouver | Türkmen A,TAGHİZADEHGHALEHJOUGHİ A,Mohammadzadeh Akın D,Genç S,Hacimuftuoglu A Investigation of Momordica Charantia Effects on Foot Inflammation Model in Rats and Behavioral Changes Due to This Inflammation; Experimental Model. Investigation of the Effects of Momordica Charantia. . 2021; 112 - 119. 10.35229/jaes.835178 |
| IEEE | Türkmen A,TAGHİZADEHGHALEHJOUGHİ A,Mohammadzadeh Akın D,Genç S,Hacimuftuoglu A "Investigation of Momordica Charantia Effects on Foot Inflammation Model in Rats and Behavioral Changes Due to This Inflammation; Experimental Model. Investigation of the Effects of Momordica Charantia." , ss.112 - 119, 2021. 10.35229/jaes.835178 |
| ISNAD | Türkmen, Aybike vd. "Investigation of Momordica Charantia Effects on Foot Inflammation Model in Rats and Behavioral Changes Due to This Inflammation; Experimental Model. Investigation of the Effects of Momordica Charantia". (2021), 112-119. https://doi.org/10.35229/jaes.835178 |
| APA | Türkmen A, TAGHİZADEHGHALEHJOUGHİ A, Mohammadzadeh Akın D, Genç S, Hacimuftuoglu A (2021). Investigation of Momordica Charantia Effects on Foot Inflammation Model in Rats and Behavioral Changes Due to This Inflammation; Experimental Model. Investigation of the Effects of Momordica Charantia. JOURNAL OF ANATOLIAN ENVIRONMENTAL AND ANIMAL SCIENCES, 6(1), 112 - 119. 10.35229/jaes.835178 |
| Chicago | Türkmen Aybike,TAGHİZADEHGHALEHJOUGHİ Ali,Mohammadzadeh Akın Dr.Maryam,Genç Sıdıka,Hacimuftuoglu Ahmet Investigation of Momordica Charantia Effects on Foot Inflammation Model in Rats and Behavioral Changes Due to This Inflammation; Experimental Model. Investigation of the Effects of Momordica Charantia. JOURNAL OF ANATOLIAN ENVIRONMENTAL AND ANIMAL SCIENCES 6, no.1 (2021): 112 - 119. 10.35229/jaes.835178 |
| MLA | Türkmen Aybike,TAGHİZADEHGHALEHJOUGHİ Ali,Mohammadzadeh Akın Dr.Maryam,Genç Sıdıka,Hacimuftuoglu Ahmet Investigation of Momordica Charantia Effects on Foot Inflammation Model in Rats and Behavioral Changes Due to This Inflammation; Experimental Model. Investigation of the Effects of Momordica Charantia. JOURNAL OF ANATOLIAN ENVIRONMENTAL AND ANIMAL SCIENCES, vol.6, no.1, 2021, ss.112 - 119. 10.35229/jaes.835178 |
| AMA | Türkmen A,TAGHİZADEHGHALEHJOUGHİ A,Mohammadzadeh Akın D,Genç S,Hacimuftuoglu A Investigation of Momordica Charantia Effects on Foot Inflammation Model in Rats and Behavioral Changes Due to This Inflammation; Experimental Model. Investigation of the Effects of Momordica Charantia. JOURNAL OF ANATOLIAN ENVIRONMENTAL AND ANIMAL SCIENCES. 2021; 6(1): 112 - 119. 10.35229/jaes.835178 |
| Vancouver | Türkmen A,TAGHİZADEHGHALEHJOUGHİ A,Mohammadzadeh Akın D,Genç S,Hacimuftuoglu A Investigation of Momordica Charantia Effects on Foot Inflammation Model in Rats and Behavioral Changes Due to This Inflammation; Experimental Model. Investigation of the Effects of Momordica Charantia. JOURNAL OF ANATOLIAN ENVIRONMENTAL AND ANIMAL SCIENCES. 2021; 6(1): 112 - 119. 10.35229/jaes.835178 |
| IEEE | Türkmen A,TAGHİZADEHGHALEHJOUGHİ A,Mohammadzadeh Akın D,Genç S,Hacimuftuoglu A "Investigation of Momordica Charantia Effects on Foot Inflammation Model in Rats and Behavioral Changes Due to This Inflammation; Experimental Model. Investigation of the Effects of Momordica Charantia." JOURNAL OF ANATOLIAN ENVIRONMENTAL AND ANIMAL SCIENCES, 6, ss.112 - 119, 2021. 10.35229/jaes.835178 |
| ISNAD | Türkmen, Aybike vd. "Investigation of Momordica Charantia Effects on Foot Inflammation Model in Rats and Behavioral Changes Due to This Inflammation; Experimental Model. Investigation of the Effects of Momordica Charantia". JOURNAL OF ANATOLIAN ENVIRONMENTAL AND ANIMAL SCIENCES 6/1 (2021), 112-119. https://doi.org/10.35229/jaes.835178 |
