TY  - JOUR
TI  - Investigation of Momordica Charantia Effects on Foot Inflammation Model in Rats and Behavioral Changes Due to This Inflammation; Experimental Model. Investigation of the Effects of Momordica Charantia
AB  - Pain is an unpleasant sensation originating from any part of the body, associated withactual or possible tissue damage, and linked to past human experiences. Momordica Charantia(MC) or bitter melon mainly is used all around the world for the treatment of diabetes, cancer andinflammation- associated conditions due to the existence of many bioactive ingredients whichhave vigorous biologic effect. The aim of our study is to investigate how low and high doses ofMC plant affect foot inflammation and animal's behavior. Sixteen male rats randomly dividedinto 4 experimental groups. Formaldehyde was (hind-paw formalin injection) administered forinducing pain model. After 24 hours MC (50 mg/kg, 200 mg/kg) was administered every day forfive days. During the experiment, the pain thresholds, locomotor activity measurements andinflamed foot volume, Locomotor Activity Test and Water Overflow Method in sequence.According to our result, when we consider the foot volume, pain threshold and locomotor activitydata of our control group, there is no significant difference between the beginning and the lastday, on the 7th day, the pain threshold continues to decrease as the foot volume of our animals inour positive control group does not decrease. 200 mg concentration of MC has provided a greattreatment by reducing the increasing foot volume at the same time pain threshold and motoractivity was in highest level at 4th day.Our experiment shows that MC (200 mg/ml MC) has high analgesic activity provides significantpain reduction and improvement in symptoms.
AU  - Türkmen, Aybike
AU  - TAGHİZADEHGHALEHJOUGHİ, Ali
AU  - Hacimuftuoglu, Ahmet
AU  - Genç, Sıdıka
AU  - Mohammadzadeh Akın, Dr.Maryam
DO  - 10.35229/jaes.835178
PY  - 2021
JO  - JOURNAL OF ANATOLIAN ENVIRONMENTAL AND ANIMAL SCIENCES
VL  - 6
IS  - 1
SN  - 2548-0006
SP  - 112
EP  - 119
DB  - TRDizin
UR  - http://search/yayin/detay/427045
ER  -