This research has been conducted to determine the relationship between postpartum depression and personality traits. The sample of this descriptive and relationship seeking study was constituted of 381 women who applied to the obstetrics outpatient clinics of a public hospital in Malatya between June and September 2018, and who were between postpartum 0-3 months. The data were collected by using face to face interview method, with; The Personal Information Form the Edinburgh Postpartum Depression Scale (EPDS) and the Ten-Item Personality Scale (TIPS). In the research, the total EPDS score average of the women was 5.66 ± 4.72, and it was determined that 14.2% (n = 54) of the women had depressive symptoms. Furthermore, a negatively-correlated significant relationshipwasfoundbetweenpost-partumdepressionandtheTIPSsubdimensionsofextraversion,conscientiousness, emotional stability and agreeableness (r = -0.142, r = -0.242, r = -0.251, r = -0.223; p <0. 05, respectively). The multiple linear regression model has showed that personality traits such as conscientiousness, emotional stability and agreeableness are important indicators of post-partum depression (β=-0.286, β=-0.316, β=-0.267; p<0.05, respectively). The study results indicate that being irresponsible, emotionally unstable and disagreeable put women at the greatest risk of suffering from post-partum depression. According to the findings, it can be said that women with low responsibility, emotionally unstable and noncompliant personality traits are at risk for postpartum depression.