Yıl: 2020 Cilt: 37 Sayı: 3 Sayfa Aralığı: 129 - 133 Metin Dili: İngilizce

Relationship between White Matter Lesions and Neutrophil–Lymphocyte Ratio in Migraine Patients

Öz:
Objectives: In this study, we aimed to compare the neutrophil/lymphocyte ratio(NLR) levels of migraine patients with and without gliotic lesions on brainmagnetic resonance imaging (MRI).Materials and Methods: The records of the patients who were followed up in the neurology outpatient clinic of Ufuk University, Faculty of Medicine, between 2016 and 2019 with the diagnosis of migraine between the ages of 18 and 50 were reviewed retrospectively. Eightysix patients without systemic, neurological, and infectious diseases between 18 and 50 years of age were included in the study. Patients were divided into two groups: Group 1 – subclinical ischemic/gliotic lesions on MRI and Group 2 – normal MRI. Subparameters and calculated NLRs in whole blood results were compared between the two groups.Results: When the two groups were compared in terms of leukocyte and neutrophil counts, a statistically significant difference was found. The leukocyte and neutrophil counts of the patients in Group 1 were significantly higher than those of Group 2 (P = 0.038/P = 0.004). NLR was higher in patients with gliotic lesions on MRI than in patients with normal MRI and was statistically significant (P = 0.016).Conclusion: This study aimed to evaluate the relationship between NLR and white matter lesions in patients with migraine. We have conducted this study to see if we can confirm this with a parameter in migraine patients with white matter lesions. Despite the small number of patients, leukocyte count, neutrophil count, and NLR were significantly higher in migraine patients with white matter lesions which support our hypothesis.
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  • 1. Murat Emre, Neurology Basic Book, Migraine Clinic and Treatment. S Saip, A Siva; Güneş Medical Bookstores, Ankara, 2013. p. 138‑49.
  • 2. Goadsby PJ, Charbit AR, Andreou AP, Akerman S, Holland PR. Neurobiology of migraine. Neuroscience 2009;161:327‑41.
  • 3. Burstein R, Jakubowski M, Rauch SD. The science of migraine. J Vestib Res 2011;21:305‑14.
  • 4. Kurth T, Slomke MA, Kase CS, Cook NR, Lee IM, Gaziano JM, et al. Migraine, headache, and the risk of stroke in women: A prospective study. Neurology 2005;64:1020‑6.
  • 5. Kurth T, Winter AC, Eliassen AH, Dushkes R, Mukamal KJ, Rimm EB, et al. Migraine and risk of cardiovascular disease in women: Prospective cohort study. BMJ 2016;353:i2610.
  • 6. Rose KM, Wong TY, Carson AP, Couper DJ, Klein R, Sharrett AR. Migraine and retinal microvascular abnormalities: The atherosclerosis risk in communities study. Neurology 2007;68:1694‑700.
  • 7. Kruit MC, Launer LJ, Ferrari MD, van Buchem MA. Brain stem and cerebellar hyperintense lesions in migraine. Stroke 2006;37:1109‑12.
  • 8. Jilma B, Blann A, Pernerstorfer T, Stohlawetz P, Eichler HG, Vondrovec B, et al. Regulation of adhesion molecules during human endotoxaemia. Am J Respir Crit Care Med 1999;159;857‑63.
  • 9. Menges T, Engel J, Welters I, Wagner RM, Little S, Ruwoldt R, et al. Changes in blood lymphocyte populations after multiple trauma. Crit Care Med 1999;27:733‑40.
  • 10. Zahorec R. Ratio of neutrophil to lymphocyte counts – Rapid and simple parameter of systemic inflammation and stress in critically ill. Bratisl Lek Listy 2001;102:5‑14.
  • 11. de Jager CP, van Wijk PT, Mathoera RB, de Jongh‑Leuvenink J, van der Poll T, Wever PC. Lymphocytopenia and neutrophil‑lymphocyte count ratio predict bacteremia better than conventional infection markers in an emergency care unit. Crit Care 2010;14:R192.
  • 12. Forget P, Khalifa C, Defour JP, Latinne D, Van Pel MC, De Kock M. What is the normal value of the neutrophil‑tolymphocyte ratio? BMC Res Notes 2017;10:12.
  • 13. Corriere T, Di Marca S, Cataudella E, Pulvirenti A, Alaimo S, Stancanelli B, et al. Neutrophil‑to‑lymphocyte ratio is a strong predictor of atherosclerotic carotid plaques in older adults. Nutr Metab Cardiovasc Dis 2018;28:23‑7.
  • 14. Phillipson M, Kubes P. The neutrophil in vascular inflammation. Nat Med 2011;17:1381‑90.
  • 15. Soehlein O. Multiple roles for neutophils in atherosclerosis. Circ Res 2012;110:875‑88.
  • 16. Libby P, Nahrendorf M, Swirski FK. Leukocytes link local and systemic inflammation in ischemic cardiovascular disease: An expanded. Cardiovascular continuum. J Am Coll Cardiol 2016;67:1091‑103.
  • 17. Lahoute C, Herbin O, Mallat Z, Tedgui A. Adaptive immunity in atherosclerosis: Mechanisms and future therapeutic targets. Nat Rev Cardiol 2011;8:348‑58.
  • 18. Lukacs M, Tajti J, Fulop F, Toldi J, Edvinsson L, Vecsei L. Migraine, neurogenic ınflammation, drug development – Pharmacochemical aspects. Curr Med Chem 2017;24:3649‑65.
  • 19. Cooney BS, Grossman RI, Farber RE, Goin JE, Galetta SL. Frequency of magnetic resonance imaging abnormalities in patients with migraine. Headache 1996;36:616‑21.
  • 20. Pavese N, Canapicchi R, Nuti A, Bibbiani F, Lucetti C, Collavoli P, et al. White matter MRI hyperintensities in a hundred and twenty‑nine consecutive migraine patients. Cephalalgia 1994;14:342‑5.
  • 21. Över F, Bıçakcı S, Sarıca Y, Sertdemir Y. White matter lesions and migraine. Turk J Neurol 2007;13:201‑6.
  • 22. Kruit MC, van Buchem MA, Hofman PA, Bakkers JT, Terwindt GM, Ferrari MD, et al. Migraine as a risk factor for subclinical brain lesions. JAMA 2004;291:427‑34.
  • 23. Swartz RH, Kern RZ. Migraine is associated with MRI white matter abnormalities: A meta‑analysis. Arch Neur 2004;61:1366‑8.
  • 24. Karabulut KU, Egercioglu TU, Uyar M, Ucar Y. The change of neutrophils/lymphocytes ratio in migraine attacks: A casecontrolled study. Ann Med Surg (Lond) 2016;10:52‑6.
  • 25. Yuan H, Silberstein SD. Histamine and migraine. Headache 2018;58:184‑93.
  • 26. Ku M, Silverman B, Prifti N, Ying W, Persaud Y, Schneider A. Prevalence of migraine headaches in patients with allergic rhinitis. Ann Allergy Asthma Immunol 2006;97:226‑30.
  • 27. Jin W, Dong C. IL‑17 cytokines in immunity and inflammation. Emerg Microbes Infect 2013;2:e60.
APA MORKAVUK G, AKKAYA E, KOÇ G, ATAC G, LEVENTOĞLU A (2020). Relationship between White Matter Lesions and Neutrophil–Lymphocyte Ratio in Migraine Patients. Neurological sciences and neurophysiology (Online), 37(3), 129 - 133.
Chicago MORKAVUK Gülin,AKKAYA Efdal,KOÇ Güray,ATAC Gökçe KAAN,LEVENTOĞLU Alev Relationship between White Matter Lesions and Neutrophil–Lymphocyte Ratio in Migraine Patients. Neurological sciences and neurophysiology (Online) 37, no.3 (2020): 129 - 133.
MLA MORKAVUK Gülin,AKKAYA Efdal,KOÇ Güray,ATAC Gökçe KAAN,LEVENTOĞLU Alev Relationship between White Matter Lesions and Neutrophil–Lymphocyte Ratio in Migraine Patients. Neurological sciences and neurophysiology (Online), vol.37, no.3, 2020, ss.129 - 133.
AMA MORKAVUK G,AKKAYA E,KOÇ G,ATAC G,LEVENTOĞLU A Relationship between White Matter Lesions and Neutrophil–Lymphocyte Ratio in Migraine Patients. Neurological sciences and neurophysiology (Online). 2020; 37(3): 129 - 133.
Vancouver MORKAVUK G,AKKAYA E,KOÇ G,ATAC G,LEVENTOĞLU A Relationship between White Matter Lesions and Neutrophil–Lymphocyte Ratio in Migraine Patients. Neurological sciences and neurophysiology (Online). 2020; 37(3): 129 - 133.
IEEE MORKAVUK G,AKKAYA E,KOÇ G,ATAC G,LEVENTOĞLU A "Relationship between White Matter Lesions and Neutrophil–Lymphocyte Ratio in Migraine Patients." Neurological sciences and neurophysiology (Online), 37, ss.129 - 133, 2020.
ISNAD MORKAVUK, Gülin vd. "Relationship between White Matter Lesions and Neutrophil–Lymphocyte Ratio in Migraine Patients". Neurological sciences and neurophysiology (Online) 37/3 (2020), 129-133.