TY - JOUR TI - Is There an Association Between Nasal Polyposis and ADAMTS Genes Expressions? AB - Objective: Nasal polyposis (NP) is an inflammatory chronic disease in which polyps are located in the nose orparanasal sinuses. A disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) genes haveroles in vascular biology, inflammation, tissue morphogenesis, and pathophysiological remodeling. Therefore,some members of the ADAMTS gene family may contribute to pathogenesis of NPs. This study aimed todetect the potential relation between NP and the expression levels of ADAMTS 5, 8, and 9 genes.Materials and Methods: This study consisted of nasal polyp tissues from 34 patients in whom nasal polypshad been diagnosed clinically, and healthy nasal mucosal tissues from 14 controls. RNA was isolated from thenasal polyps and normal nasal mucosal tissue in each subject. The expression levels of ADAMTS 5, 8, and 9genes in the patients and controls were detected by quantitative real-time reverse transcriptase polymerasechain reaction (qRT-PCR) method.Results: The expression levels of ADAMTS 5 and 9 genes were significantly decreased in NP tissues. Incontrast, the expression levels of ADAMTS 8 genes were also decreased in NP tissues, but they were notsignificantly different from those in the normal nasal tissues.Conclusion: An association was detected between the expression levels of ADAMTS genes and NP. ADAMTS 5 and 9 genes may have an effect on the formation of NP AU - Tatar, Abdulgani AU - keles, muzaffer AU - Yuce Kahraman, Cigdem AU - Ocak, Zeynep AU - Tatar, Arzu DO - 10.5152/eurasianjmed.2021.20006 PY - 2021 JO - Eurasian Journal of Medicine VL - 53 IS - 1 SN - 1308-8734 SP - 19 EP - 21 DB - TRDizin UR - http://search/yayin/detay/428353 ER -