TY  - JOUR
TI  - Destructive Effects of Acidic Blood on the Intestines: Experimental Study
AB  - Objective: This study aimed to investigate the destructive effects of acidic blood on the intestinal structures,which has been reported as the most hazardous biochemical result of vagosympathetic autonomic imbalances in intensive care unit patients with subarachnoid hemorrhage (SAH).Materials and Methods: In total, 27 hybrid rabbits were used; 5 rabbits were used as a control group, 7 asthe SHAM group into whom 1 cc saline was injected into the cisterna magna, and the remaining 15 wereused as the study group. These animals received 1 cc of autologous arterial blood injection into the cisternamagna to create the SAH group. Blood pH values were recorded before, during, and after the experimentalprocedures. Computed tomography was performed to examine the intestinal morphology. Normal and degenerated epithelial cell densities of the intestine were estimated by stereological methods. The relationshipbetween pH values and intestinal tissue changes was analyzed statistically using the Mann–Whitney U test.Results: The mean blood pH values were 7.364±0.042 in the control group, 7.326±0.059 in the SHAMgroup, and 7.23±0.021 in the study group. Intestinal epithelial cell injury, desquamation of villus, and cell losswere observed. It is observed that the number of degenerated epithelial cells, fragmented villi numbers, andvacuoles significantly increased in the study group (p<0.05).Conclusion: Acidotic intestinal injury secondary to blood pH changes following SAH may be considered as ageneralized and dangerous complication with their multiorgan insuficiency effect.
AU  - AYDIN, Muhammed Enes
AU  - çağlar, özgür
AU  - karadeniz, erdem
AU  - Aydin, Mehmet Dumlu
AU  - Ceylan, Onur
AU  - fırıncı, binali
AU  - Kantarci, Mecit
DO  - 10.5152/eurasianjmed.2021.20035
PY  - 2021
JO  - Eurasian Journal of Medicine
VL  - 53
IS  - 1
SN  - 1308-8734
SP  - 22
EP  - 27
DB  - TRDizin
UR  - http://search/yayin/detay/428370
ER  -