Evaluation of nano sized Mg@BTC metal organic framework as a drug carrier: A long term experimental and predictive theoretical study

AKYÜZ, Güliz; ANDAÇ, Müberra; Elmas, Aykut; ANDAC, Omer

doi:10.17515/resm2020.199na0613

Evaluation of nano sized Mg@BTC metal organic framework as a drug carrier: A long term experimental and predictive theoretical study

Güliz AKYÜZ, (Ondokuz Mayıs Üniversitesi, Nanobilim ve Nanoteknoloji Bölümü, Samsun, Türkiye)

Aykut ELMAS, (Ondokuz Mayıs Üniversitesi, Nanobilim ve Nanoteknoloji Bölümü, Samsun, Türkiye)

Müberra ANDAÇ, (Ondokuz Mayıs Üniversitesi, Nanobilim ve Nanoteknoloji Bölümü, Samsun, Türkiye)

Ömer ANDAÇ (Ondokuz Mayıs Üniversitesi, Nanobilim ve Nanoteknoloji Bölümü, Samsun, Türkiye)

Research on Engineering Structures and Materials

4 0

Yıl: 2021 Cilt: 7 Sayı: 1 Sayfa Aralığı: 135 - 156 Metin Dili: İngilizce DOI: 10.17515/resm2020.199na0613 İndeks Tarihi: 29-06-2021

Evaluation of nano sized Mg@BTC metal organic framework as a drug carrier: A long term experimental and predictive theoretical study

Öz:

Metal Organic Frameworks (MOFs) have found wide applications as a drugcarrier in nanotherapeutics because of adjustable pore-sizes, controllablestructural properties, large surface area and high pore volume. In this work,nanosized Mg@BTC is synthesized by electrochemical method and used as a newdrug carrier for ibuprofen. The ibuprofen (IB) is loaded to the Mg@BTC 1:1 ratiowith the amount of %99.8. The release of ibuprofen from nanocarrier has beenobserved experimentally for long term. After 100.5 hours, the release ratio yields36 %. The ibuprofen has been tested at 40 ± 0.5 °C. System showed a rapidrelease after 100 hours, the release ratio yields 72.29 %. The release profile ofIB loaded Mg@BTC is tested by using model depended mathematical models toget observation and prediction of the release. Zero Order Model, First OrderModel, Higuchi Model, Peppas Model and Hixon Model functions are fitted to therelease profiles. Watson’s U Squared Method is used to test the fit strength of themodels. Observation from the release profiles, it is seemed Peppas Model yieldsthe best results. Also, thermodynamic analysis has been studied.

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APA	AKYÜZ G, Elmas A, ANDAÇ M, ANDAC O (2021). Evaluation of nano sized Mg@BTC metal organic framework as a drug carrier: A long term experimental and predictive theoretical study. , 135 - 156. 10.17515/resm2020.199na0613
Chicago	AKYÜZ Güliz,Elmas Aykut,ANDAÇ Müberra,ANDAC Omer Evaluation of nano sized Mg@BTC metal organic framework as a drug carrier: A long term experimental and predictive theoretical study. (2021): 135 - 156. 10.17515/resm2020.199na0613
MLA	AKYÜZ Güliz,Elmas Aykut,ANDAÇ Müberra,ANDAC Omer Evaluation of nano sized Mg@BTC metal organic framework as a drug carrier: A long term experimental and predictive theoretical study. , 2021, ss.135 - 156. 10.17515/resm2020.199na0613
AMA	AKYÜZ G,Elmas A,ANDAÇ M,ANDAC O Evaluation of nano sized Mg@BTC metal organic framework as a drug carrier: A long term experimental and predictive theoretical study. . 2021; 135 - 156. 10.17515/resm2020.199na0613
Vancouver	AKYÜZ G,Elmas A,ANDAÇ M,ANDAC O Evaluation of nano sized Mg@BTC metal organic framework as a drug carrier: A long term experimental and predictive theoretical study. . 2021; 135 - 156. 10.17515/resm2020.199na0613
IEEE	AKYÜZ G,Elmas A,ANDAÇ M,ANDAC O "Evaluation of nano sized Mg@BTC metal organic framework as a drug carrier: A long term experimental and predictive theoretical study." , ss.135 - 156, 2021. 10.17515/resm2020.199na0613
ISNAD	AKYÜZ, Güliz vd. "Evaluation of nano sized Mg@BTC metal organic framework as a drug carrier: A long term experimental and predictive theoretical study". (2021), 135-156. https://doi.org/10.17515/resm2020.199na0613

APA	AKYÜZ G, Elmas A, ANDAÇ M, ANDAC O (2021). Evaluation of nano sized Mg@BTC metal organic framework as a drug carrier: A long term experimental and predictive theoretical study. Research on Engineering Structures and Materials, 7(1), 135 - 156. 10.17515/resm2020.199na0613
Chicago	AKYÜZ Güliz,Elmas Aykut,ANDAÇ Müberra,ANDAC Omer Evaluation of nano sized Mg@BTC metal organic framework as a drug carrier: A long term experimental and predictive theoretical study. Research on Engineering Structures and Materials 7, no.1 (2021): 135 - 156. 10.17515/resm2020.199na0613
MLA	AKYÜZ Güliz,Elmas Aykut,ANDAÇ Müberra,ANDAC Omer Evaluation of nano sized Mg@BTC metal organic framework as a drug carrier: A long term experimental and predictive theoretical study. Research on Engineering Structures and Materials, vol.7, no.1, 2021, ss.135 - 156. 10.17515/resm2020.199na0613
AMA	AKYÜZ G,Elmas A,ANDAÇ M,ANDAC O Evaluation of nano sized Mg@BTC metal organic framework as a drug carrier: A long term experimental and predictive theoretical study. Research on Engineering Structures and Materials. 2021; 7(1): 135 - 156. 10.17515/resm2020.199na0613
Vancouver	AKYÜZ G,Elmas A,ANDAÇ M,ANDAC O Evaluation of nano sized Mg@BTC metal organic framework as a drug carrier: A long term experimental and predictive theoretical study. Research on Engineering Structures and Materials. 2021; 7(1): 135 - 156. 10.17515/resm2020.199na0613
IEEE	AKYÜZ G,Elmas A,ANDAÇ M,ANDAC O "Evaluation of nano sized Mg@BTC metal organic framework as a drug carrier: A long term experimental and predictive theoretical study." Research on Engineering Structures and Materials, 7, ss.135 - 156, 2021. 10.17515/resm2020.199na0613
ISNAD	AKYÜZ, Güliz vd. "Evaluation of nano sized Mg@BTC metal organic framework as a drug carrier: A long term experimental and predictive theoretical study". Research on Engineering Structures and Materials 7/1 (2021), 135-156. https://doi.org/10.17515/resm2020.199na0613