Yıl: 2021 Cilt: 46 Sayı: 1 Sayfa Aralığı: 395 - 400 Metin Dili: İngilizce DOI: 10.17826/cumj.866381 İndeks Tarihi: 30-06-2021

Evaluation of clinical and pathological features of mixed endometrial carcinoma in a tertiary medical center

Öz:
Purpose: The aim of this study was to evaluate the clinicaland pathological characteristics of mixed endometrialcarcinoma (MEC).Materials and Methods: The clinical and pathologicalrecords of the 29 MEC patients, who were operated onand regularly followed up in the clinic between January2000 and December 2019, were reviewed. Clinicpathologic features and survival in the MEC group (n=29)were compared to pure serous (n=42) and pure clear celladenocarcinomas (n=13). Clinical features, operationcharacteristics, pathological findings, myometrial invasiondegree (MI), lymph node involvement (LNI),lymphovascular space invasion (LVSI), adjuvant therapies,and follow-up data of the patients and their effects onsurvival were investigated.Results: Eighteen of the cases had endometrioid + serous,7 had endometrioid + clear, 3 had endometrioid + serous,and 1 had clear + serous histopathology. Laparoscopicsurgery was performed in 8 of the cases (27.6%) in themixed group. Stage, the rate of LVSI, LNI, MI ≥50%, andomental metastasis were similar among the groups. Therewere no significant differences in the rates of receivingadjuvant therapy among the groups. Overall survive (OS)was similar among the groups.Conclusion: MECs are tumors that can be difficult todiagnose and manage. There was no difference betweenMEC and pure serous carcinoma (SC) and pure clear cellcarcinoma (CC) in terms of clinicopathological featuresand prognosis. In addition to histopathological features,revealing and evaluating their molecular properties willhelp us to better understand this group of tumors.
Anahtar Kelime:

Miks endometriyal karsinomun klinik ve patolojik özelliklerinin tersiyer bir merkezde değerlendirilmesi

Öz:
Amaç: Bu çalışmada miks endometrial karsinomun (MEK) klinik ve patolojik özelliklerini değerlendirilmesi amaçlanmıştır. Gereç ve Yöntem: Ocak 2000 - Aralık 2019 tarihleri arasında kliniğimizde ameliyat edilen ve düzenli takip edilen 29 MEK hastasının klinik ve patolojik kayıtları gözden geçirildi. MEK grubundaki (n = 29) klinikpatolojik özellikler ve sağkalım, saf seröz (n = 42) ve saf berrak hücreli adenokarsinomlar (n = 13) ile karşılaştırıldı. Hastaların klinik bulguları, operasyon özellikleri, patolojik bulguları, miyometriyal invazyon derecesi (MI), lenf nodu tutulumu (LNI), lenfovasküler alan invazyonu (LVSI), adjuvan tedaviler ve takip verileri ve sağkalıma etkileri araştırıldı. Bulgular: Olguların 18'inde endometrioid + seröz, 7'sinde endometrioid + berrak hücreli, 3'ünde endometrioid + seröz ve 1'inde berrak hücreli+ seröz histopatoloji vardı. Hastaların ortalama yaşı 63,2 ± 12,1 yıldı. Mikst gruptaki olguların 8'ine (% 27,6) laparoskopik cerrahi uygulandı. Evre, LVSI, LNI, MI ≥% 50 ve omental metastaz oranları gruplar arasında benzerdi. Adjuvan tedavi alma oranları için gruplar arasında önemli bir fark yoktu. Genel olarak hayatta kalma süresi gruplar arasında benzerdi. Sonuç: MEK'ler, teşhis edilmesi ve yönetilmesi zor olabilen tümörlerdir. Klinikopatolojik özellikler ve prognoz açısından MEK ile saf seröz karsinom ve saf berrak hücreli karsinom arasında fark yoktu. Histopatolojik özelliklerinin yanı sıra moleküler özelliklerinin ortaya çıkarılması ve değerlendirilmesi bu grup tümörleri daha iyi anlamamıza yardımcı olacaktır.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA Sucu M, GEÇKİL Ö, akçabay ç, Khatib G, Kucukgoz Gulec U, güzel a, vardar M (2021). Evaluation of clinical and pathological features of mixed endometrial carcinoma in a tertiary medical center. , 395 - 400. 10.17826/cumj.866381
Chicago Sucu Mete,GEÇKİL Ömer Faruk,akçabay çiğdem,Khatib Ghanim,Kucukgoz Gulec Umran,güzel ahmet barış,vardar Mehmet Evaluation of clinical and pathological features of mixed endometrial carcinoma in a tertiary medical center. (2021): 395 - 400. 10.17826/cumj.866381
MLA Sucu Mete,GEÇKİL Ömer Faruk,akçabay çiğdem,Khatib Ghanim,Kucukgoz Gulec Umran,güzel ahmet barış,vardar Mehmet Evaluation of clinical and pathological features of mixed endometrial carcinoma in a tertiary medical center. , 2021, ss.395 - 400. 10.17826/cumj.866381
AMA Sucu M,GEÇKİL Ö,akçabay ç,Khatib G,Kucukgoz Gulec U,güzel a,vardar M Evaluation of clinical and pathological features of mixed endometrial carcinoma in a tertiary medical center. . 2021; 395 - 400. 10.17826/cumj.866381
Vancouver Sucu M,GEÇKİL Ö,akçabay ç,Khatib G,Kucukgoz Gulec U,güzel a,vardar M Evaluation of clinical and pathological features of mixed endometrial carcinoma in a tertiary medical center. . 2021; 395 - 400. 10.17826/cumj.866381
IEEE Sucu M,GEÇKİL Ö,akçabay ç,Khatib G,Kucukgoz Gulec U,güzel a,vardar M "Evaluation of clinical and pathological features of mixed endometrial carcinoma in a tertiary medical center." , ss.395 - 400, 2021. 10.17826/cumj.866381
ISNAD Sucu, Mete vd. "Evaluation of clinical and pathological features of mixed endometrial carcinoma in a tertiary medical center". (2021), 395-400. https://doi.org/10.17826/cumj.866381
APA Sucu M, GEÇKİL Ö, akçabay ç, Khatib G, Kucukgoz Gulec U, güzel a, vardar M (2021). Evaluation of clinical and pathological features of mixed endometrial carcinoma in a tertiary medical center. Cukurova Medical Journal, 46(1), 395 - 400. 10.17826/cumj.866381
Chicago Sucu Mete,GEÇKİL Ömer Faruk,akçabay çiğdem,Khatib Ghanim,Kucukgoz Gulec Umran,güzel ahmet barış,vardar Mehmet Evaluation of clinical and pathological features of mixed endometrial carcinoma in a tertiary medical center. Cukurova Medical Journal 46, no.1 (2021): 395 - 400. 10.17826/cumj.866381
MLA Sucu Mete,GEÇKİL Ömer Faruk,akçabay çiğdem,Khatib Ghanim,Kucukgoz Gulec Umran,güzel ahmet barış,vardar Mehmet Evaluation of clinical and pathological features of mixed endometrial carcinoma in a tertiary medical center. Cukurova Medical Journal, vol.46, no.1, 2021, ss.395 - 400. 10.17826/cumj.866381
AMA Sucu M,GEÇKİL Ö,akçabay ç,Khatib G,Kucukgoz Gulec U,güzel a,vardar M Evaluation of clinical and pathological features of mixed endometrial carcinoma in a tertiary medical center. Cukurova Medical Journal. 2021; 46(1): 395 - 400. 10.17826/cumj.866381
Vancouver Sucu M,GEÇKİL Ö,akçabay ç,Khatib G,Kucukgoz Gulec U,güzel a,vardar M Evaluation of clinical and pathological features of mixed endometrial carcinoma in a tertiary medical center. Cukurova Medical Journal. 2021; 46(1): 395 - 400. 10.17826/cumj.866381
IEEE Sucu M,GEÇKİL Ö,akçabay ç,Khatib G,Kucukgoz Gulec U,güzel a,vardar M "Evaluation of clinical and pathological features of mixed endometrial carcinoma in a tertiary medical center." Cukurova Medical Journal, 46, ss.395 - 400, 2021. 10.17826/cumj.866381
ISNAD Sucu, Mete vd. "Evaluation of clinical and pathological features of mixed endometrial carcinoma in a tertiary medical center". Cukurova Medical Journal 46/1 (2021), 395-400. https://doi.org/10.17826/cumj.866381