Diagnostic Use of Interleukin-33 Levels in Patients with Acute Cholangitis Requiring Early or Emergency Biliary Drainage
Yıl: 2021 Cilt: 7 Sayı: 2 Sayfa Aralığı: 289 - 295 Metin Dili: Türkçe DOI: 10.53394/akd.959931 İndeks Tarihi: 29-07-2022
Diagnostic Use of Interleukin-33 Levels in Patients with Acute Cholangitis Requiring Early or Emergency Biliary Drainage
Öz: Objective: Treatment of cholangitis is life-saving in patients with severe acute cholangitis (AC).We aimed to investigate usefulness of interleukin-33 (IL-33) to discriminate need of early or urgentbiliary drainage in patients with acute cholangitis according to Tokyo Guidelines 2018 (TG18) gradingsystem.Material and Methods: The study population consisted of a total of 79 subjects (48 AC and31 healthy controls). Patients with AC were categorized based on TG18, and the IL-33 levels andlaboratory markers were measured.Results: IL-33 level was significantly higher in the AC group (p <0.0001). ROC curve analysis wasperformed to distinguish patients with AC from normal healthy patients and to determine a cutoff value for IL-33. As a result of this analysis, the cut-off value for serum IL-33 was 0.59 pg / mL(sensitivity: 83.3% (95% CI: 69.8-92.5), specificity: 90.3% (95% CI: 74.2-98.0)) and the area under theROC curve (AUC) was found to be 0.902 (p <0.0001; 95% CI: 0.814-0.957). The median IL-33 levelwas significantly higher in patients who needed early/emergency biliary drainage (moderate or severeAC) compared to patients with mild AC (0.79 vs 0.60, p = 0.01).Conclusion: This study showed that IL-33 increased significantly in patients with moderate/severeAC who need immediate biliary drainage.
Anahtar Kelime: İnterlökin-33 Düzeylerinin Erken veya Acil Safra Drenajı Gerektiren Akut Kolanjitli Hastalarda Tanısal Kullanımı
Öz: Amaç: Şiddetli akut kolanjiti (AK) olan hastalarda kolanjit tedavisi hayat kurtarıcı öneme sahiptir. Bu çalışmada akut kolanjitli hastalarda IL-33'ün erken veya acil biliyer drenaj ihtiyacını ayırt etmek için kullanılabilirliğini 2018 Tokyo kılavuzu (TG18) derecelendirme sistemine göre araştırılmasını amaçladık. Gereç ve Yöntemler: Çalışma popülasyonu toplam 79 kişiden oluşmaktaydı (48 AK ve 31 sağlıklı kontrol). Akut kolanjitli hastalar TG18'e göre kategorize edildi ve hastaların IL-33 düzeyleri ve laboratuvar belirteçleri ölçüldü. Bulgular: IL-33 düzeyi AK grubunda anlamlı olarak yüksekti (p <0.0001). Akut kolanjitli hastaları normal sağlıklı hastalardan ayırt edilmesi ve IL-33 için bir cut-off değeri belirlemek için ROC eğrisi analizi yapılmıştır. Bu analiz sonucunda serum IL-33 için cut-off değeri 0.59 pg/mL (duyarlılık:% 83.3 (% 95 CI: 69.8-92.5), özgüllük:% 90.3 (% 95 CI: 74.2-98.0) bulundu ) ve ROC eğrisinin altındaki alan (AUC) ise 0.902 (p <0.0001;% 95 CI: 0.814-0.957) olarak bulunmuştur. Erken/acil biliyer drenaja ihtiyaç duyan (orta veya şiddetli AK) hastalarda, hafif akut kolanjitli hastalara göre ortanca IL-33 düzeyi anlamlı olarak daha yüksek bulunmuştur (0.79 vs 0.60, p = 0.01). Sonuç: Bu çalışmada IL-33'ün acil safra drenajına ihtiyaç duyan orta/şiddetli AK hastalarında önemli ölçüde arttığı gösterilmiştir
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | Gokbulut V, odemis b, Kalkan İ, kaplan m, Arı D, Kılıc Z, kayacetin e, Tenlik İ (2021). Diagnostic Use of Interleukin-33 Levels in Patients with Acute Cholangitis Requiring Early or Emergency Biliary Drainage. , 289 - 295. 10.53394/akd.959931 |
| Chicago | Gokbulut Volkan,odemis bulent,Kalkan İsmail,kaplan mustafa,Arı Derya,Kılıc Zeki,kayacetin ertugrul,Tenlik İlyas Diagnostic Use of Interleukin-33 Levels in Patients with Acute Cholangitis Requiring Early or Emergency Biliary Drainage. (2021): 289 - 295. 10.53394/akd.959931 |
| MLA | Gokbulut Volkan,odemis bulent,Kalkan İsmail,kaplan mustafa,Arı Derya,Kılıc Zeki,kayacetin ertugrul,Tenlik İlyas Diagnostic Use of Interleukin-33 Levels in Patients with Acute Cholangitis Requiring Early or Emergency Biliary Drainage. , 2021, ss.289 - 295. 10.53394/akd.959931 |
| AMA | Gokbulut V,odemis b,Kalkan İ,kaplan m,Arı D,Kılıc Z,kayacetin e,Tenlik İ Diagnostic Use of Interleukin-33 Levels in Patients with Acute Cholangitis Requiring Early or Emergency Biliary Drainage. . 2021; 289 - 295. 10.53394/akd.959931 |
| Vancouver | Gokbulut V,odemis b,Kalkan İ,kaplan m,Arı D,Kılıc Z,kayacetin e,Tenlik İ Diagnostic Use of Interleukin-33 Levels in Patients with Acute Cholangitis Requiring Early or Emergency Biliary Drainage. . 2021; 289 - 295. 10.53394/akd.959931 |
| IEEE | Gokbulut V,odemis b,Kalkan İ,kaplan m,Arı D,Kılıc Z,kayacetin e,Tenlik İ "Diagnostic Use of Interleukin-33 Levels in Patients with Acute Cholangitis Requiring Early or Emergency Biliary Drainage." , ss.289 - 295, 2021. 10.53394/akd.959931 |
| ISNAD | Gokbulut, Volkan vd. "Diagnostic Use of Interleukin-33 Levels in Patients with Acute Cholangitis Requiring Early or Emergency Biliary Drainage". (2021), 289-295. https://doi.org/10.53394/akd.959931 |
| APA | Gokbulut V, odemis b, Kalkan İ, kaplan m, Arı D, Kılıc Z, kayacetin e, Tenlik İ (2021). Diagnostic Use of Interleukin-33 Levels in Patients with Acute Cholangitis Requiring Early or Emergency Biliary Drainage. Akdeniz Tıp Dergisi, 7(2), 289 - 295. 10.53394/akd.959931 |
| Chicago | Gokbulut Volkan,odemis bulent,Kalkan İsmail,kaplan mustafa,Arı Derya,Kılıc Zeki,kayacetin ertugrul,Tenlik İlyas Diagnostic Use of Interleukin-33 Levels in Patients with Acute Cholangitis Requiring Early or Emergency Biliary Drainage. Akdeniz Tıp Dergisi 7, no.2 (2021): 289 - 295. 10.53394/akd.959931 |
| MLA | Gokbulut Volkan,odemis bulent,Kalkan İsmail,kaplan mustafa,Arı Derya,Kılıc Zeki,kayacetin ertugrul,Tenlik İlyas Diagnostic Use of Interleukin-33 Levels in Patients with Acute Cholangitis Requiring Early or Emergency Biliary Drainage. Akdeniz Tıp Dergisi, vol.7, no.2, 2021, ss.289 - 295. 10.53394/akd.959931 |
| AMA | Gokbulut V,odemis b,Kalkan İ,kaplan m,Arı D,Kılıc Z,kayacetin e,Tenlik İ Diagnostic Use of Interleukin-33 Levels in Patients with Acute Cholangitis Requiring Early or Emergency Biliary Drainage. Akdeniz Tıp Dergisi. 2021; 7(2): 289 - 295. 10.53394/akd.959931 |
| Vancouver | Gokbulut V,odemis b,Kalkan İ,kaplan m,Arı D,Kılıc Z,kayacetin e,Tenlik İ Diagnostic Use of Interleukin-33 Levels in Patients with Acute Cholangitis Requiring Early or Emergency Biliary Drainage. Akdeniz Tıp Dergisi. 2021; 7(2): 289 - 295. 10.53394/akd.959931 |
| IEEE | Gokbulut V,odemis b,Kalkan İ,kaplan m,Arı D,Kılıc Z,kayacetin e,Tenlik İ "Diagnostic Use of Interleukin-33 Levels in Patients with Acute Cholangitis Requiring Early or Emergency Biliary Drainage." Akdeniz Tıp Dergisi, 7, ss.289 - 295, 2021. 10.53394/akd.959931 |
| ISNAD | Gokbulut, Volkan vd. "Diagnostic Use of Interleukin-33 Levels in Patients with Acute Cholangitis Requiring Early or Emergency Biliary Drainage". Akdeniz Tıp Dergisi 7/2 (2021), 289-295. https://doi.org/10.53394/akd.959931 |
