TY  - JOUR
TI  - Diagnostic Use of Interleukin-33 Levels in Patients with Acute Cholangitis Requiring Early or Emergency Biliary Drainage
AB  - Objective: Treatment of cholangitis is life-saving in patients with severe acute cholangitis (AC).We aimed to investigate usefulness of interleukin-33 (IL-33) to discriminate need of early or urgentbiliary drainage in patients with acute cholangitis according to Tokyo Guidelines 2018 (TG18) gradingsystem.Material and Methods: The study population consisted of a total of 79 subjects (48 AC and31 healthy controls). Patients with AC were categorized based on TG18, and the IL-33 levels andlaboratory markers were measured.Results: IL-33 level was significantly higher in the AC group (p <0.0001). ROC curve analysis wasperformed to distinguish patients with AC from normal healthy patients and to determine a cutoff value for IL-33. As a result of this analysis, the cut-off value for serum IL-33 was 0.59 pg / mL(sensitivity: 83.3% (95% CI: 69.8-92.5), specificity: 90.3% (95% CI: 74.2-98.0)) and the area under theROC curve (AUC) was found to be 0.902 (p <0.0001; 95% CI: 0.814-0.957). The median IL-33 levelwas significantly higher in patients who needed early/emergency biliary drainage (moderate or severeAC) compared to patients with mild AC (0.79 vs 0.60, p = 0.01).Conclusion: This study showed that IL-33 increased significantly in patients with moderate/severeAC who need immediate biliary drainage.
AU  - Arı, Derya
AU  - odemis, bulent
AU  - Kalkan, İsmail
AU  - kaplan, mustafa
AU  - kayacetin, ertugrul
AU  - Gokbulut, Volkan
AU  - Kılıc, Zeki
AU  - Tenlik, İlyas
DO  - 10.53394/akd.959931
PY  - 2021
JO  - Akdeniz Tıp Dergisi
VL  - 7
IS  - 2
SN  - 1300-1779
SP  - 289
EP  - 295
DB  - TRDizin
UR  - http://search/yayin/detay/436779
ER  -