Expression of Connexin 32 and Connexin 43 in Adenomatous Polyps and Hyperplastic Polyps

CANKAYA, Soner; ASLAN, Ali; Doğangüzel, Zeynep; erdem, havva

doi:10.26453/otjhs.796295

Expression of Connexin 32 and Connexin 43 in Adenomatous Polyps and Hyperplastic Polyps

Havva ERDEM, (Ordu Üniversitesi, Tıp Fakültesi, Patoloji Anabilim Dalı, Ordu, Türkiye)

Ali ASLAN, (Ordu Üniversitesi, Tıp Fakültesi, Fizyoloji Bölümü, Ordu, Türkiye)

Soner ÇANKAYA, (Ondokuz Mayıs Üniversitesi, Spor Bilimleri Fakültesi, Spor Yöneticiliği Bölümü, Samsun, Türkiye)

Zeynep DOĞANGÜZEL (Ordu Üniversitesi, Tıp Fakültesi, Patoloji Anabilim Dalı, Ordu, Türkiye)

Online Türk Sağlık Bilimleri Dergisi

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Yıl: 2021 Cilt: 6 Sayı: 3 Sayfa Aralığı: 327 - 332 Metin Dili: İngilizce DOI: 10.26453/otjhs.796295 İndeks Tarihi: 29-07-2022

Expression of Connexin 32 and Connexin 43 in Adenomatous Polyps and Hyperplastic Polyps

Öz:

Objective: Although connexins are thought to providenormally functioning gap junctions via a tumor suppressorgene, new studies point to an abnormal increase of connexins in various carcinomas and sarcomas. Therefore itwas aimed to investigate the expression of connexin 43(Cx43) and connexin 32 (Cx32) in adenomatous and hyperplastic polyps.Materials and Methods: This retrospective studyincluded 32 cases with adenomatous polyps and 42 caseswith hyperplastic polyps, between 2014 and 2015. Thesamples were stained with immunohistochemical stainingmethod with Cx43 and Cx32 and evaluated.Results: In our study, we observed that Cx43 and Cx32staining increased in hyperplastic polyps compared to adenomatous polyps (p=0.039, p=0.048 respectively). Statistically, there were no significant correlations between age,sex, location, and diameter with staining pattern.Conclusion: Loss of Cx43 and Cx32 staining in adenomatous polyps was noted and thought to be related to dysplasia

Anahtar Kelime: connexin 43 hyperplastic polyps Adenomatous polyps connexin 32

Adenomatöz ve Hiperplastik Poliplerde Konneksin 32 ve Konneksin 43 Ekspresyonu

Öz:

Amaç: Konneksinlerin tümör baskılayıcı bir gen yoluyla normal işleyen geçit bağlantıları sağladığı düşünülse de yeni çalışmalar çeşitli karsinom ve sarkomlarda konneksinlerin anormal artışına işaret etmektedir. Bu nedenle adenomatöz ve hiperplastik poliplerde connexin 43 (Cx43) ve connexin 32 (Cx32) ekspresyonunun araştırılması amaçlandı. Materyal ve Metot: Bu retrospektif çalışmaya 2014- 2015 yılları arasında adenomatöz polipli 32 olgu ve hiperplastik polipli 42 olgu dahil edildi. Örnekler Cx43 ve Cx32 ile immünohistokimyasal boyama yöntemi ile boyandı ve değerlendirildi. Bulgular: Çalışmamızda, hiperplastik poliplerde adenomatöz poliplere göre Cx43 ve Cx32 boyanmalarının arttığını gözlemledik (sırasıyla p=0,039, p=0,048). İstatistiksel olarak yaş, cinsiyet, yerleşim yeri ve çap ile boyama paterni arasında anlamlı bir ilişki yoktu. Sonuç: Adenomatöz poliplerde Cx43 ve Cx32 boyanmasının azaldığı ve bu durumun displazi ile ilişkili olduğu düşünüldü.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	erdem h, ASLAN A, CANKAYA S, Doğangüzel Z (2021). Expression of Connexin 32 and Connexin 43 in Adenomatous Polyps and Hyperplastic Polyps. , 327 - 332. 10.26453/otjhs.796295
Chicago	erdem havva,ASLAN Ali,CANKAYA Soner,Doğangüzel Zeynep Expression of Connexin 32 and Connexin 43 in Adenomatous Polyps and Hyperplastic Polyps. (2021): 327 - 332. 10.26453/otjhs.796295
MLA	erdem havva,ASLAN Ali,CANKAYA Soner,Doğangüzel Zeynep Expression of Connexin 32 and Connexin 43 in Adenomatous Polyps and Hyperplastic Polyps. , 2021, ss.327 - 332. 10.26453/otjhs.796295
AMA	erdem h,ASLAN A,CANKAYA S,Doğangüzel Z Expression of Connexin 32 and Connexin 43 in Adenomatous Polyps and Hyperplastic Polyps. . 2021; 327 - 332. 10.26453/otjhs.796295
Vancouver	erdem h,ASLAN A,CANKAYA S,Doğangüzel Z Expression of Connexin 32 and Connexin 43 in Adenomatous Polyps and Hyperplastic Polyps. . 2021; 327 - 332. 10.26453/otjhs.796295
IEEE	erdem h,ASLAN A,CANKAYA S,Doğangüzel Z "Expression of Connexin 32 and Connexin 43 in Adenomatous Polyps and Hyperplastic Polyps." , ss.327 - 332, 2021. 10.26453/otjhs.796295
ISNAD	erdem, havva vd. "Expression of Connexin 32 and Connexin 43 in Adenomatous Polyps and Hyperplastic Polyps". (2021), 327-332. https://doi.org/10.26453/otjhs.796295

APA	erdem h, ASLAN A, CANKAYA S, Doğangüzel Z (2021). Expression of Connexin 32 and Connexin 43 in Adenomatous Polyps and Hyperplastic Polyps. Online Türk Sağlık Bilimleri Dergisi, 6(3), 327 - 332. 10.26453/otjhs.796295
Chicago	erdem havva,ASLAN Ali,CANKAYA Soner,Doğangüzel Zeynep Expression of Connexin 32 and Connexin 43 in Adenomatous Polyps and Hyperplastic Polyps. Online Türk Sağlık Bilimleri Dergisi 6, no.3 (2021): 327 - 332. 10.26453/otjhs.796295
MLA	erdem havva,ASLAN Ali,CANKAYA Soner,Doğangüzel Zeynep Expression of Connexin 32 and Connexin 43 in Adenomatous Polyps and Hyperplastic Polyps. Online Türk Sağlık Bilimleri Dergisi, vol.6, no.3, 2021, ss.327 - 332. 10.26453/otjhs.796295
AMA	erdem h,ASLAN A,CANKAYA S,Doğangüzel Z Expression of Connexin 32 and Connexin 43 in Adenomatous Polyps and Hyperplastic Polyps. Online Türk Sağlık Bilimleri Dergisi. 2021; 6(3): 327 - 332. 10.26453/otjhs.796295
Vancouver	erdem h,ASLAN A,CANKAYA S,Doğangüzel Z Expression of Connexin 32 and Connexin 43 in Adenomatous Polyps and Hyperplastic Polyps. Online Türk Sağlık Bilimleri Dergisi. 2021; 6(3): 327 - 332. 10.26453/otjhs.796295
IEEE	erdem h,ASLAN A,CANKAYA S,Doğangüzel Z "Expression of Connexin 32 and Connexin 43 in Adenomatous Polyps and Hyperplastic Polyps." Online Türk Sağlık Bilimleri Dergisi, 6, ss.327 - 332, 2021. 10.26453/otjhs.796295
ISNAD	erdem, havva vd. "Expression of Connexin 32 and Connexin 43 in Adenomatous Polyps and Hyperplastic Polyps". Online Türk Sağlık Bilimleri Dergisi 6/3 (2021), 327-332. https://doi.org/10.26453/otjhs.796295