Changes in the seroepidemiological pattern of Helicobacter pylori infection over the last 10 years in Turkey

ÖZDEN, Ali; ÖZKAN, Muhip; KÖSE, Kenan S.; BOZDAYI, Gülendam

Changes in the seroepidemiological pattern of Helicobacter pylori infection over the last 10 years in Turkey

Ali ÖZDEN, (Ankara Üniversitesi, Tıp Fakültesi, Gastroenteroloji Bilim Dalı, Ankara, Türkiye)

Gülendam BOZDAYI, (Gazi Üniversitesi, Tıp Fakültesi, Mikrobiyoloji ve Klinik Mikrobiyoloji Anabilim Dalı, Ankara, Türkiye)

Muhip ÖZKAN, (Ankara Üniversitesi, Ziraat Fakültesi, Ankara, Türkiye)

Kenan S. KÖSE (Ankara Üniversitesi, Dikimevi Sağlık Hizmetleri Meslek Yüksek Okulu Ankara, Türkiye)

Turkish Journal of Gastroenterology

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Yıl: 2004 Cilt: 15 Sayı: 3 Sayfa Aralığı: 156 - 158 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Changes in the seroepidemiological pattern of Helicobacter pylori infection over the last 10 years in Turkey

Öz:

Amaç: Bu çalışmanın amacı, Türk çocuklarında 10 yıllık bir zaman dilimi içerisinde, Helicobacter pylori infeksiyonunda oluşan seroepidemiyolojik değişiklikleri belirlemektir. Yöntem: Ankara’nın kenar mahallelerinde bulunan bir ilkokuldaki sağlıklı öğrencilerden 1990 (219 adet) ve 2000 (184 adet) yıllarında Helicobacter pylori serolojisi araştırılmak üzere toplam 403 serum örneği toplanmıştır. Bulgular: Toplanan serum örneklerinde ELISA yontemi ile Helicobacter pylori Ig G antikorları araştırılmıştır. Tüm grup genel olarak değerlendirildiğinde Helicobacter pylori antikoru sıklığı 1990 yılında % 78.5 iken, 2000 yılında % 66.3 olarak bulunmuştur. 10 yıllık bir dönem içerisinde helicobacter pylori prevelansı düşüş göstermektedir (p<0.01). 1990 yılında Helicobacter pylori infeksiyonuna en duyarlı yaş grubu 10 yaş iken (89.5%), 2000 yılında en duyarlı yaş grubu 8 yaş grubudur. Sonuç: Bulgularımız, 1990-2000 yılları arasında Helicobacter pylori seroprevalansının düşmekte olduğunu göstermektedir. Bu değişiklikler çevresel faktörlerdeki düzelmeyle ve Türkiye’nin sosyoekonomik durumundaki iyileşmeye bağlı olabilir.

Anahtar Kelime: Seroepidemiyolojik çalışmalar Helicobacter enfeksiyonları Türkiye Helicobacter pylori Seroloji

Konular: Cerrahi

Türkiye’de son 10 yılda Helicaobacter pylori sero-epidemiyolojisinde meydana gelen değişiklikler

Öz:

Background/aims: This study was undertaken to evaluate changes in the seroepidemiological pattern of Helicobacter pylori in a group of Turkish children over a span of 10 years. Methods: A total of 403 (219+184) serum samples were obtained from a primary school located in the urban part of Ankara in 1990 and 2000. All of the samples were from healthy students aged 7-14 (in 1990, n= 219, 109 females; and in 2000, n= 184, 90 females). Results: All serum samples were assayed for Helicobacter pylori IgG by means of enzyme-linked immunosorbent assay. The overall prevalence of Helicobacter pylori antibodies was 78.5% in 1990 and 66.3% in 2000. The prevalence of Helicobacter pylori was found to be decreasing over a time span of 10 years (p<0.01). While the most susceptible age group to Helicobacter pylori in 1990 was 10 years (89.5%), in 2000 the susceptible age group was 8 years (85.0%). Conclusions: Our data suggest that the seroprevalence of Helicobacter pylori infection seems to have decreased during the last 10 years in Turkey. This change may be attributable to the changes in environmental condition and socioeconomic development that have taken place in the country.

Anahtar Kelime: Turkey Helicobacter pylori Serology Seroepidemiologic Studies Helicobacter Infections

Konular: Cerrahi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

1. Drumm B, Sherman P, Cutz E. Association of Campylobacter pylori on the gastric mucosa with antral gastritis in children. N Engl J Med 1987; 316: 1157-61.
2. Graham DY. Campylobacter pylori and peptic ulcer disease. Gastroenterology 1989; 96(Suppl): 5615-25.
3. NIH Consensus Development Panel on Helicobacter pylori in peptic ulcer disease. Helicobacter pylori in peptic ulcer disease. JAMA 1994; 272: 65-9.
4. Wotherspoon AC, Doglioni C, Diss TC, et al. Regression of primary low-grade B cell gastric lymphoma of mucosa-associated lymphoid tissue after eradication of Helicobacter pylori. Lancet 1993; 342: 575-7.
5. Megraud F. Epidemiology of Helicobacter pylori infection. Gastroenterol Clin North Am 1993; 22:73-88.
6. Atherton JC. Non-endoscopic tests in the diagnosis of Helicobacter pylori infection. Aliment Pharmacol Ther 1997; 11:11-20.
7. Cutler AF, Harstad S, Ma CK. Accuracy of invasive and noninvasive tests to diagnose Helicobacter pylori infection. Gastroenterology 1995; 109: 136-41.
8. Pounder RE, Ng D. The prevalence of Helicobacter pylori infection in different countries. Aliment Pharmacol Ther 1995; 9(Suppl): 33-35. 9. Torres J, Leal-Herrera Y, Perez-Perez G. A community-based seroepidemiologic study of Helicobacter pylori infection in Mexico. J Infect Dis 1998; 178: 1089-94.
10. Rothenbacter D, Bode G, Berg G. Prevalence and determinants of Helicobacter pylori infection in preschool children: a population-based study from Germany. Int J Epidemiol 1998; 27: 135-41.
11. Loffeld RJ, Van der Putien AB. The occurrence of a duodenal or gastric ulcer in two different populations living in the same region: a cross-sectional endoscopical study in consecutive patients. Neth J Med 2001; 59: 209-12.
12. Fleis JL. Statistical Methods for Rates and Proportion. New York: John Wiley and Sons, Inc.; 1981.
13. Asaka M, Kimura T, Kuda M, et al. Relationship of Helicobacter pylori to serum pepsinogens in an asymptomatic Japanese population. Gastroenterology 1992; 102: 760-6.
14. Raymond J, Bergert M, Benhamou H, et al. A 2-year study of H. pylori in children. J Clin Microbiol 1994; 32: 461-3.
15. Matysiak-Budnik T, Megraud F. H. pylori in eastern European countries: what is the current status. Gut 1994; 35: 1683-6.

APA	ÖZDEN A, BOZDAYI G, ÖZKAN M, KÖSE K (2004). Changes in the seroepidemiological pattern of Helicobacter pylori infection over the last 10 years in Turkey. , 156 - 158.
Chicago	ÖZDEN Ali,BOZDAYI Gülendam,ÖZKAN Muhip,KÖSE Kenan S. Changes in the seroepidemiological pattern of Helicobacter pylori infection over the last 10 years in Turkey. (2004): 156 - 158.
MLA	ÖZDEN Ali,BOZDAYI Gülendam,ÖZKAN Muhip,KÖSE Kenan S. Changes in the seroepidemiological pattern of Helicobacter pylori infection over the last 10 years in Turkey. , 2004, ss.156 - 158.
AMA	ÖZDEN A,BOZDAYI G,ÖZKAN M,KÖSE K Changes in the seroepidemiological pattern of Helicobacter pylori infection over the last 10 years in Turkey. . 2004; 156 - 158.
Vancouver	ÖZDEN A,BOZDAYI G,ÖZKAN M,KÖSE K Changes in the seroepidemiological pattern of Helicobacter pylori infection over the last 10 years in Turkey. . 2004; 156 - 158.
IEEE	ÖZDEN A,BOZDAYI G,ÖZKAN M,KÖSE K "Changes in the seroepidemiological pattern of Helicobacter pylori infection over the last 10 years in Turkey." , ss.156 - 158, 2004.
ISNAD	ÖZDEN, Ali vd. "Changes in the seroepidemiological pattern of Helicobacter pylori infection over the last 10 years in Turkey". (2004), 156-158.

APA	ÖZDEN A, BOZDAYI G, ÖZKAN M, KÖSE K (2004). Changes in the seroepidemiological pattern of Helicobacter pylori infection over the last 10 years in Turkey. Turkish Journal of Gastroenterology, 15(3), 156 - 158.
Chicago	ÖZDEN Ali,BOZDAYI Gülendam,ÖZKAN Muhip,KÖSE Kenan S. Changes in the seroepidemiological pattern of Helicobacter pylori infection over the last 10 years in Turkey. Turkish Journal of Gastroenterology 15, no.3 (2004): 156 - 158.
MLA	ÖZDEN Ali,BOZDAYI Gülendam,ÖZKAN Muhip,KÖSE Kenan S. Changes in the seroepidemiological pattern of Helicobacter pylori infection over the last 10 years in Turkey. Turkish Journal of Gastroenterology, vol.15, no.3, 2004, ss.156 - 158.
AMA	ÖZDEN A,BOZDAYI G,ÖZKAN M,KÖSE K Changes in the seroepidemiological pattern of Helicobacter pylori infection over the last 10 years in Turkey. Turkish Journal of Gastroenterology. 2004; 15(3): 156 - 158.
Vancouver	ÖZDEN A,BOZDAYI G,ÖZKAN M,KÖSE K Changes in the seroepidemiological pattern of Helicobacter pylori infection over the last 10 years in Turkey. Turkish Journal of Gastroenterology. 2004; 15(3): 156 - 158.
IEEE	ÖZDEN A,BOZDAYI G,ÖZKAN M,KÖSE K "Changes in the seroepidemiological pattern of Helicobacter pylori infection over the last 10 years in Turkey." Turkish Journal of Gastroenterology, 15, ss.156 - 158, 2004.
ISNAD	ÖZDEN, Ali vd. "Changes in the seroepidemiological pattern of Helicobacter pylori infection over the last 10 years in Turkey". Turkish Journal of Gastroenterology 15/3 (2004), 156-158.