Celiac disease in patients having recurrent aphthous stomatitis

Aktunc, Erol; üstündağ, yücel; AYDEMİR, Selim; TEKİN, Solak Nilgün; NUMANOĞLU, Gamze

Celiac disease in patients having recurrent aphthous stomatitis

Selim AYDEMİR, (Zonguldak Karaelmas Üniversitesi, Tıp Fakültesi, Gastroenteroloji Bilim Dalı, Zonguldak, Türkiye)

Solak Nilgün TEKİN, (Zonguldak Karaelmas Üniversitesi, Tıp Fakültesi, Dermatoloji Anabilim Dalı, Zonguldak, Türkiye)

Erol AKTUNÇ, (Zonguldak Karaelmas Üniversitesi, Tıp Fakültesi, Aile Hekimliği Anabilim Dalı, Zonguldak, Türkiye)

Gamze NUMANOĞLU, (Zonguldak Karaelmas Üniversitesi, Tıp Fakültesi, Patoloji Anabilim Dalı, Zonguldak, Türkiye)

Yücel ÜSTÜNDAĞ (Zonguldak Karaelmas Üniversitesi, Tıp Fakültesi, Gastroenteroloji Bilim Dalı, Zonguldak, Türkiye)

Turkish Journal of Gastroenterology

0 0

Yıl: 2004 Cilt: 15 Sayı: 3 Sayfa Aralığı: 192 - 195 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Celiac disease in patients having recurrent aphthous stomatitis

Öz:

Amaç: Celiac hastalığı ince barsakların glutene intoleransı sonucu oluşan bir hastalıktır. Epidemiolojik çalışmalarda prevalansı hakkında çok farklı veriler vardı. Hastalarda genellikle çok geniş spektrumda semptom ve bulgulara neden olabildiğinden celiac hastalığı tanısının konulması zor olabilmektedir. Hastalığın erken evrede yakalanması önemlidir. Çünkü bu hastalarda barsak lenfoması gelişme riski artmıştır. Celiac hastalığı olan hastalarda rekürren aftoz stomatit prevalansındaki yükseklik nedeniyle rekürren aftoz stomatitli hastaların celiac hastalığı yönünden araştırılması asemptomatik celiac hastalığı olan hastaların tanı almasını sağlayabilir. Bu çalışma rekürren aftoz stomatit nedeniyle başvuran olgularda celiac hastalığı prevalansını saptamak için planlanmıştır. Yöntem: Çalışma gurubu olarak rekürren aftoz stomatit öyküsü olan, kontrol grubu olarak ise rekürren aftoz stomatit öyküsü olmayan olgular alındı. Tüm olgularda anti gliadin IgG, antigliadin IgA ve anti endomisium antikorları bakıldı. Ayrıca endoskopi yapılarak duodenum distal kesiminden biyopsiler alındı. Bulgular: Rekürren aftoz stomatit öyküsü olan 41 olgunun ikisinde patolojik inceleme ile doğrulanan celiac hastalığı bulundu (%4.8). Celiac hastalığı saptanan bu iki olgunun her ikisinde de anti gliadin IgA ve endomisium antikorları pozitif bulundu. Anti gliadin IgG antikoru ise olguların birinde pozitifti. Kontrol grubundaki 49 olgunun hiçbirinde celiac hastalığı saptanmadı. Sonuç: Rekürren aftoz stomatit olgularında celiac hastalığı açısında ileri incelenmeler yapılmalıdır. Endoskopinin invaziv ve daha pahalı olması nedeniyle rekürren aftoz stomatitli olgularda celiac hastalığı ı araştırmak için öncelikli olarak serolojik tetkikler yapılmalı, seroljik markır pozitif olan olgularda endoskopik olarak duodenum ikinci kesiminden biyopsiler alınmalıdır.

Anahtar Kelime: Çölyak hastalığı Yaygınlık Stomatit, aftöz

Konular: Cerrahi

Rekürren aftoz stomatitli hastalarda Celiac hastalığı

Öz:

Background/aims: Celiac disease is a condition related to the small intestine’s intolerance to gluten. In epidemiologic studies the prevalence is highly variable. The diagnosis can be difficult due to the wide spectrum of signs and symptoms. As the risk for intestinal lymphoma is higher in these patients, early diagnosis has its privileges. The higher prevalence of recurrent aphthous stomatitis in celiac disease led us to investigate the celiac disease prevalence in patients with recurrent aphthous stomatitis, which might assist in diagnosis of asymptomatic celiac disease patients. The aim of this study was to determine the prevalence of celiac disease in patients presenting with recurrent aphthous stomatitis. Methods: The study group consisted of patients having a history of recurrent aphthous stomatitis. The control group included patients not having aphthous stomatitis. Antibodies to gliadin IgG and IgA and antibodies to endomysium were determined from the serum samples of all patients. Biopsies were obtained from the distal part of the duodenum. Results: Biopsies of two patients (4.8%) out of 41 belonging to the study group were diagnosed as celiac disease. In serum samples of both, antibodies to gliadin IgA and antibodies to endomysium were found to be positive. Antibodies to gliadin IgG antibody were positive in only one of these two patients. None of the 49 patients in the control group was diagnosed as celiac disease. Conclusion: Further evaluation of recurrent aphthous stomatitis patients for celiac disease must be performed. As the endoscopic procedures are invasive and costly, evaluation of recurrent aphthous stomatitis patients for celiac disease must include serologic markers at the beginning. If any positivity is determined in markers, then endoscopic procedures including biopsies of the duodenum must be considered as the second-step intervention.

Anahtar Kelime: Prevalence Stomatitis, Aphthous Celiac Disease

Konular: Cerrahi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

TRDizin Dışındaki Atıf Sayıları

OpenCitations: 0

OpenAlex: 0

Crossref: 0

1. Greco L, Corazza G, Babron MC, et al. Genome search in celiac disease. Am J Hum Genet 1998; 62: 669-75.
2. Sollid LM. Molecular basis of celiac disease. Annu Rev Im¬ munol 2000; 18: 53-81.
3. Corazza GR, Gasbarrini G. Coeliac disease in adults. Bail- lieres Clin Gastroenterol 1995; 9: 329-50. 4. Hill ID, Bhatnagar S, Cameron DJ, et al. Celiac disease: Working Group Report of the First World Congress of Pediatric Gastroenterology, Hepatology, and Nutrition. J Pediatr Gastroenterol Nutr 2002; 35 Suppl 2: 78-88.
5. Sedghizadeh PP, Shuler CF, Allen CM, et al. Celiac disease and recurrent aphthous stomatitis: a report and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2002; 94: 474-8.
6. Collin P, Maki M. Associated disorders in coeliac disease: clinical aspects. Scand J Gastroenterol 1994; 29: 769-75.
7. Reunala T, Blomqvist K, Tarpila S, et al. Gluten-free diet in dermatitis herpetiformis. I. Clinical response of skin lesions in 81 patients. Br J Dermatol 1977; 97: 473-80.
8. Porter SR, Scully C, Pedersen A. Recurrent aphthous stomatitis. Grit Rev Oral Biol Med 1998; 9: 306-21.
9. Rogers RS III. Recurrent aphthous stomatitis: clinical cha¬racteristics and associated systemic disorders. Semin Cu-tan Med Surg 1997; 16: 278-83.
10. Ship JA. Recurrent aphthous stomatitis. An update. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1996; 81: 141-7.
11. Ferguson MM, Wray D, Carmichael HA, et al. Coeliac disease associated with recurrent aphthae. Gut 1980; 21: 223-6.
12. Lahteenoja H, Toivanen A, Viander M, et al. Oral mucosal changes in coeliac patients on a gluten-free diet. Eur J Oral Sci 1998; 106: 899-906.
13. Veloso FT, Saleiro JV. Small-bowel changes in recurrent ulceration of the mouth. Hepatogastroenterology 1987; 34: 36-7. 14. Biemond I, Pena AS, Groenland F, et al. Coeliac disease in The Netherlands: demographic data of a patient survey among the members of the Dutch Coeliac Society. Neth J Med 1987; 31: 263-8.
15. Carrozzo M, Carbone M, Gandolfo S. [Recurrent aphthous stomatitis: current etiopathogenetic and therapeutic concepts]. Minerva Stomatol 1995; 44: 467-75.
16. Jokinen J, Peters U, Maki M, et al. Celiac sprue in patients with chronic oral mucosal symptoms. J Clin Gastroenterol 1998; 26: 23-6.
17. Wray D, Ferguson MM, Mason DK, et al. Recurrent aphthae: treatment with vitamin B12, folic acid, and iron. Br Med J 1975; 2: 490-3.
18. Ferguson R, Basu MK, Asquith P, Cooke WT. Jejunal mucosal abnormalities in patients with recurrent aphthous ulceration. Br Med J 1976; 1: 11-3.
19. Grodzinsky E, Franzen L, Hed J, Strom M. High prevalence of celiac disease in healthy adults revealed by antigliadin antibodies. Ann Allergy 1992; 69: 66-70.
20. Maki M. The humoral immune system in coeliac disease. Baillieres Clin Gastroenterol 1995; 9: 231-49.

APA	AYDEMİR S, TEKİN S, Aktunc E, NUMANOĞLU G, üstündağ y (2004). Celiac disease in patients having recurrent aphthous stomatitis. , 192 - 195.
Chicago	AYDEMİR Selim,TEKİN Solak Nilgün,Aktunc Erol,NUMANOĞLU Gamze,üstündağ yücel Celiac disease in patients having recurrent aphthous stomatitis. (2004): 192 - 195.
MLA	AYDEMİR Selim,TEKİN Solak Nilgün,Aktunc Erol,NUMANOĞLU Gamze,üstündağ yücel Celiac disease in patients having recurrent aphthous stomatitis. , 2004, ss.192 - 195.
AMA	AYDEMİR S,TEKİN S,Aktunc E,NUMANOĞLU G,üstündağ y Celiac disease in patients having recurrent aphthous stomatitis. . 2004; 192 - 195.
Vancouver	AYDEMİR S,TEKİN S,Aktunc E,NUMANOĞLU G,üstündağ y Celiac disease in patients having recurrent aphthous stomatitis. . 2004; 192 - 195.
IEEE	AYDEMİR S,TEKİN S,Aktunc E,NUMANOĞLU G,üstündağ y "Celiac disease in patients having recurrent aphthous stomatitis." , ss.192 - 195, 2004.
ISNAD	AYDEMİR, Selim vd. "Celiac disease in patients having recurrent aphthous stomatitis". (2004), 192-195.

APA	AYDEMİR S, TEKİN S, Aktunc E, NUMANOĞLU G, üstündağ y (2004). Celiac disease in patients having recurrent aphthous stomatitis. Turkish Journal of Gastroenterology, 15(3), 192 - 195.
Chicago	AYDEMİR Selim,TEKİN Solak Nilgün,Aktunc Erol,NUMANOĞLU Gamze,üstündağ yücel Celiac disease in patients having recurrent aphthous stomatitis. Turkish Journal of Gastroenterology 15, no.3 (2004): 192 - 195.
MLA	AYDEMİR Selim,TEKİN Solak Nilgün,Aktunc Erol,NUMANOĞLU Gamze,üstündağ yücel Celiac disease in patients having recurrent aphthous stomatitis. Turkish Journal of Gastroenterology, vol.15, no.3, 2004, ss.192 - 195.
AMA	AYDEMİR S,TEKİN S,Aktunc E,NUMANOĞLU G,üstündağ y Celiac disease in patients having recurrent aphthous stomatitis. Turkish Journal of Gastroenterology. 2004; 15(3): 192 - 195.
Vancouver	AYDEMİR S,TEKİN S,Aktunc E,NUMANOĞLU G,üstündağ y Celiac disease in patients having recurrent aphthous stomatitis. Turkish Journal of Gastroenterology. 2004; 15(3): 192 - 195.
IEEE	AYDEMİR S,TEKİN S,Aktunc E,NUMANOĞLU G,üstündağ y "Celiac disease in patients having recurrent aphthous stomatitis." Turkish Journal of Gastroenterology, 15, ss.192 - 195, 2004.
ISNAD	AYDEMİR, Selim vd. "Celiac disease in patients having recurrent aphthous stomatitis". Turkish Journal of Gastroenterology 15/3 (2004), 192-195.