TY  - JOUR
TI  - Limb salvage surgery of primary and metastatic bone tumors of the lower extremity: Functional outcomes and survivorship of modular endoprosthetic reconstruction
AB  - Objective: The study was aimed to determine the survivorship and functional outcomes of modular endoprosthetic reconstruction in the management of primary and metastatic bone tumors of the lower limbs and to investigate the rate and causes ofimplant failure.Methods: A total of 84 limbs of 82 patients (49 male, 33 female; mean age=48 years, age range=13–78 years) with a minimumfollow-up of 12 months in whom resection and modular endoprosthetic reconstructions were performed for primary or metastatic bone tumors of the lower extremity were retrospectively reviewed and included in the study. The mean follow-up was 43(range=13–119) months. Functional status was assessed using the Musculoskeletal Tumor Society (MSTS) scoring system at thefinal follow-up. Implant survival was defined as the time from implantation until partial or complete exchange of the prosthesissecondary to mechanical or nonmechanical causes or amputation. The effects of the anatomical site on functional scores andimplant survival were statistically analyzed. Additionally, the effects of diagnosis and adjuvant treatments on functional scores,implant survival, and failure rates were investigated.Results: At the time of the study, 55 patients were still alive with a mean follow-up of 48 (range=15–119) months. The meanMSTS scores resulting from the final follow-up of all patients and of those surviving were 87.9% (range=16%–100%) and 86.8%(range=16%–100%), respectively. Overall implant survival was 95.2%, 89.2%, 87%, and 87% at 1, 2, 3, and 4 years, respectively.Statistically, both functional scores and implant survival analysis in different anatomical sites were found similar. In 15 of thepatients (17.8%), endoprosthetic reconstructions had failed. The causes of failure were soft tissue failure (dislocation) in 5 patients, infection in 5, structural/mechanical failure in 2, local recurrence in two, and aseptic loosening in one. The diagnosis andreceiving preoperative and/or postoperative adjuvant treatment did not affect functional scores, implant survival or failure rates.Conclusion: The results of this study have shown that modular endoprosthetic replacement can provide satisfactory functional resultsand a durable mid-term limb salvage option in the management of patients with primary and metastatic bone tumors of the lower limbs.Level of Evidence: Level IV, Therapeutic Study
AU  - Topkar, Osman Mert
AU  - sirin, evrim
AU  - SOFULU, OMER
AU  - Erol, Bulent
DO  - 10.5152/j.aott.2021.20101
PY  - 2021
JO  - Acta Orthopaedica et Traumatologica Turcica
VL  - 55
IS  - 2
SN  - 1017-995X
SP  - 147
EP  - 153
DB  - TRDizin
UR  - http://search/yayin/detay/446170
ER  -