Objective: The aim of this study was to determine the effect of adding dexmedetomidine to intra-articular levobupivacaine onpostoperative pain levels and analgesic requirements following arthroscopic meniscectomy.Methods: A total of 60 American Society of Anesthesiologist physical status I-II patients, aged 20 to 62 years, and scheduled forarthroscopic partial meniscectomy under general anesthesia were included in this study. All the patients were randomlyassigned to one of four groups (15 patients in each group): Group 1 (8 male, 7 female; mean age = 46.70 ± 13.13 years; 0.9%isotonic 20 ml), group 2 (7 male, 8 female; mean age = 42.60 ± 12.18 years; levobupivacaine 0.5 mg/kg plus 0.9% isotonic), group 3(8 male, 7 female; mean age = 43.80 ± 12.63 years; 1μg/kg dexmedetomidine plus 0.9% isotonic), and group 4 (7 female, 8 male;mean age = 40.40 ± 11.79 years; levobupivacaine 0.5 mg/kg plus 1μg/kg dexmedetomidine and 0.9% isotonic). All medicationswere administered at the end of arthroscopic surgery. Pain levels were measured using a Visual Analogous Scale (VAS) andVerbal Rating Scale (VRS) at postoperative 1, 2, 4, 6, 12, and 24 hours.Results: VAS scores at rest were significantly lower in Group 4 at postoperative 1th, 2nd, 4th, 6th,12th, and 24th hours than in othergroups. The time to take the first analgesic was significantly higher in Group4 (964 ± 288 min), and total analgesic consumptionwas significantly lower in Group 4 compared to those of other groups.Conclusion: Although administration of intra-articular dexmedetomidine alone may have a weaker effect than intra-articularlevobupivacaine on postoperative pain relief after arthroscopic partial meniscectomy, adding dexmedetomidine to intra-articularlevobupivacaine may increase the durationand quality of postoperative analgesia without any side effect.Level of Evidence: Level I, Therapeutic Study