The Relationship Between Bone Mineral Density Values and Prognostic Nutritional Index As Well As Serum Trace Element Levels in Postmenopausal Women

Kul, Ayhan; ÇELİK, Muhammet; bayraktutan, zafer

doi:10.4274/tod.galenos.2020.97658

The Relationship Between Bone Mineral Density Values and Prognostic Nutritional Index As Well As Serum Trace Element Levels in Postmenopausal Women

Ayhan KUL, (Atatürk Üniversitesi Tıp Fakültesi, Fiziksel Tıp ve Rehabilitasyon Anabilim Dalı, Erzurum, Türkiye)

Zafer BAYRAKTUTAN, (Atatürk Üniversitesi, Tıp Fakültesi, Tıbbi Biyokimya Anabilim Dalı, Erzurum, Türkiye)

Muhammet ÇELİK (Atatürk Üniversitesi, Tıp Fakültesi, Tıbbi Biyokimya Anabilim Dalı, Erzurum, Türkiye)

Türk Osteoporoz Dergisi

5 0

Yıl: 2021 Cilt: 27 Sayı: 2 Sayfa Aralığı: 82 - 89 Metin Dili: İngilizce DOI: 10.4274/tod.galenos.2020.97658 İndeks Tarihi: 01-10-2021

The Relationship Between Bone Mineral Density Values and Prognostic Nutritional Index As Well As Serum Trace Element Levels in Postmenopausal Women

Öz:

Objective: The relationship between bone mineral density (BMD) values and nutritional status as well as serum copper (Cu), zinc (Zn),selenium (Se) and manganese (Mn) levels in postmenopausal women has not been fully elucidated. Therefore, this study aimed to investigatewhether there is a relationship between BMD values and nutritional status as well as serum Cu, Zn, Se and Mn levels by evaluating thenutritional status of postmenopausal women based on the BMD values using an objective index.Materials and Methods: The study included 105 postmenopausal women who were divided into the following 3 groups: Controls (controlgroup, n=30, T-score >-1.0), patients with osteopaenia (osteopaenia group, n=30, T-score >-2.5) and patients with osteoporosis (osteoporosisgroup, n=45, T-score ≤-2.5). Moreover, the nutritional status of the patients was determined using the prognostic nutritional index (PNI), whichis calculated based on the serum albumin levels and total lymphocyte count. Further, serum Cu, Zn, Se and Mn levels were also determined.The relationship between BMD and PNI as well as the serum levels of Cu, Zn, Se and Mn was investigated.Results: The mean age and body mass index (BMI) of the participants were found to be similar in all the groups [control group (age, 63.4±5.2years; BMI, 33.7±5.6 kg/m2); osteopaenia group (age, 64.6±5.3 years; BMI, 33.5±5.9 kg/m2) and osteoporosis group (age, 65.8±5 years;BMI, 30.9±7.2 kg/m2)]. In the osteoporosis group, the PNI and serum albumin, Cu and Zn levels were significantly lower than those in thecontrol group (p<0.05), and a weak positive correlation was observed between lumbar total BMD values and PNI as well as serum albuminand Mn levels (p<0.05). Furthermore, a positive moderate correlation between PNI and serum Zn levels was observed in the osteoporosisgroup (p=0.045, r=0.063).Conclusion: Low serum albumin levels and a low PNI, particularly in postmenopausal patients with osteoporosis, may have an adverse effecton the total BMD in the lumbar region. Furthermore, Zn supplementation in patients with osteoporosis having low PNI can be a potentialadditional treatment strategy. Cu and Mn supplementation may also provide an additional benefit to existing treatments.

Anahtar Kelime:

Postmenapozal Kadınlarda Kemik Mineral Yoğunluğunun Prognostik Nutrisyonel İndeks ve Eser Elementler ile Olan İlişkisi

Öz:

Amaç: Postmenopozal kadınlarda kemik mineral yoğunluğunun (KMY) nutrisyonel durum ve serum bakır (Cu), çinko (Zn), selenyum (Se) ve manganez (Mn) seviyeleri ile olan ilişkisi tam olarak aydınlatılamamıştır. Bu nedenle postmenopozal kadınların KMY değerlerine göre nutrisyonel durumunu objektif bir indeks ile değerlendirerek Cu, Zn, Se ve Mn ile arasında bir ilişki olup olmadığını incelemeyi amaçladık. Gereç ve Yöntem: Çalışmada postmenopozal olan 105 kadın üç gruba ayrıldı; kontroller (kontrol grup, n=30, T-skoru >-1,0), osteopenik hastalar (osteopenik grup, n=30, T-skoru >-2,5) ve osteoporotik hastalar (osteoporotik grup, n=45, T-score ≤-2,5). Hastaların nutrisyonel durumlarının belirlenmesinde serum albümin ve total lenfosit sayısını içeren prognostik nutrisyonel indeks (PNI) kullanıldı. Cu, Zn, Se ve Mn eser elementlerinin serum seviyeleri belirlendi. KMY ile PNI ve eser elementlerin serum seviyeleri arasındaki ilişki incelendi. Bulgular: Katılımcıların ortalama yaş ve vücut kitle indeksi (VKİ) tüm gruplarda benzerdi. [Kontrol grubu (yaş, 63,4±5,2 yıl; VKİ, 33,7±5,6 kg/ m2 ); osteopeni grubu (yaş, 64,6±5,3 yıl; VKİ, 33,5±5,9 kg/m2 ) ve osteoporozis grubu (yaş, 65,8±5 yıl; VKİ, 30,9±7,2 kg/m2 )]. Osteoporoz grubunda; PNI, albümin, serum Cu ve Zn seviyelerinin kontrol grubuna göre anlamlı şekilde daha düşük olduğu (p<0,05) ve lomber total KMY değerleri ile PNI, albümin ve serum Mn seviyesi arasında pozitif zayıf bir korelasyon olduğu bulundu (p<0,05). Ayrıca osteoporoz grubunda PNI ile serum Zn seviyesi arasında pozitif orta düzeyde bir korelasyon olduğu tespit edildi (p=0,045, r=0,063).Sonuç: Postmenopozal osteoporoz hastalarında özellikle düşük serum albümin düzeyi ve/veya düşük PNI değeri lomber bölgedeki total KMY’yi olumsuz yönde etkileyebilir. Ayrıca düşük PNI değeri olan osteoporoz hastalarında Zn takviyesinin yapılması potansiyel ek bir tedavi stratejisi olabilir. Bununla birlikte Cu ve Mn bileşiklerinin takviyesi mevcut tedavilere ek olarak fayda sağlayabilir

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Kul A, bayraktutan z, ÇELİK M (2021). The Relationship Between Bone Mineral Density Values and Prognostic Nutritional Index As Well As Serum Trace Element Levels in Postmenopausal Women. , 82 - 89. 10.4274/tod.galenos.2020.97658
Chicago	Kul Ayhan,bayraktutan zafer,ÇELİK Muhammet The Relationship Between Bone Mineral Density Values and Prognostic Nutritional Index As Well As Serum Trace Element Levels in Postmenopausal Women. (2021): 82 - 89. 10.4274/tod.galenos.2020.97658
MLA	Kul Ayhan,bayraktutan zafer,ÇELİK Muhammet The Relationship Between Bone Mineral Density Values and Prognostic Nutritional Index As Well As Serum Trace Element Levels in Postmenopausal Women. , 2021, ss.82 - 89. 10.4274/tod.galenos.2020.97658
AMA	Kul A,bayraktutan z,ÇELİK M The Relationship Between Bone Mineral Density Values and Prognostic Nutritional Index As Well As Serum Trace Element Levels in Postmenopausal Women. . 2021; 82 - 89. 10.4274/tod.galenos.2020.97658
Vancouver	Kul A,bayraktutan z,ÇELİK M The Relationship Between Bone Mineral Density Values and Prognostic Nutritional Index As Well As Serum Trace Element Levels in Postmenopausal Women. . 2021; 82 - 89. 10.4274/tod.galenos.2020.97658
IEEE	Kul A,bayraktutan z,ÇELİK M "The Relationship Between Bone Mineral Density Values and Prognostic Nutritional Index As Well As Serum Trace Element Levels in Postmenopausal Women." , ss.82 - 89, 2021. 10.4274/tod.galenos.2020.97658
ISNAD	Kul, Ayhan vd. "The Relationship Between Bone Mineral Density Values and Prognostic Nutritional Index As Well As Serum Trace Element Levels in Postmenopausal Women". (2021), 82-89. https://doi.org/10.4274/tod.galenos.2020.97658

APA	Kul A, bayraktutan z, ÇELİK M (2021). The Relationship Between Bone Mineral Density Values and Prognostic Nutritional Index As Well As Serum Trace Element Levels in Postmenopausal Women. Türk Osteoporoz Dergisi, 27(2), 82 - 89. 10.4274/tod.galenos.2020.97658
Chicago	Kul Ayhan,bayraktutan zafer,ÇELİK Muhammet The Relationship Between Bone Mineral Density Values and Prognostic Nutritional Index As Well As Serum Trace Element Levels in Postmenopausal Women. Türk Osteoporoz Dergisi 27, no.2 (2021): 82 - 89. 10.4274/tod.galenos.2020.97658
MLA	Kul Ayhan,bayraktutan zafer,ÇELİK Muhammet The Relationship Between Bone Mineral Density Values and Prognostic Nutritional Index As Well As Serum Trace Element Levels in Postmenopausal Women. Türk Osteoporoz Dergisi, vol.27, no.2, 2021, ss.82 - 89. 10.4274/tod.galenos.2020.97658
AMA	Kul A,bayraktutan z,ÇELİK M The Relationship Between Bone Mineral Density Values and Prognostic Nutritional Index As Well As Serum Trace Element Levels in Postmenopausal Women. Türk Osteoporoz Dergisi. 2021; 27(2): 82 - 89. 10.4274/tod.galenos.2020.97658
Vancouver	Kul A,bayraktutan z,ÇELİK M The Relationship Between Bone Mineral Density Values and Prognostic Nutritional Index As Well As Serum Trace Element Levels in Postmenopausal Women. Türk Osteoporoz Dergisi. 2021; 27(2): 82 - 89. 10.4274/tod.galenos.2020.97658
IEEE	Kul A,bayraktutan z,ÇELİK M "The Relationship Between Bone Mineral Density Values and Prognostic Nutritional Index As Well As Serum Trace Element Levels in Postmenopausal Women." Türk Osteoporoz Dergisi, 27, ss.82 - 89, 2021. 10.4274/tod.galenos.2020.97658
ISNAD	Kul, Ayhan vd. "The Relationship Between Bone Mineral Density Values and Prognostic Nutritional Index As Well As Serum Trace Element Levels in Postmenopausal Women". Türk Osteoporoz Dergisi 27/2 (2021), 82-89. https://doi.org/10.4274/tod.galenos.2020.97658