TY  - JOUR
TI  - EXPRESSIONS OF IGF-1R, EZH2, LAMININ-5 IN LEUKOPLAKIA AND ORAL SQUAMOUS CELL CARCINOMA
AB  - Aim: The aim of this study is to investigate the expressions of IGF-1R, EZH2 and Laminin-5 antibodies in biopsy samples ofleukoplakia and squamous cell carcinoma of the oral mucosa by immunohistochemistry method.Materials and Methods: The study consisted of three groups; oral squamous cell carcinoma leukoplakia and control groups.The control group consisted of lesions with oral fibrous hyperplasia diagnosis. Biopsies of 38 patients for oral squamous cellcarcinoma, 32 patients for leukoplakia and 15 patients for control group were examined and evaluated degree of staining ofantibodies. Antibodies were evaluated as negative (0-10%):0, 1 positive (11-30%):+, 2 positive (31-60%):++, 3 positive (61-100%):+++ according to staining percentages. The staining degrees of antibodies were compared with Mann Whitney U test instudy and control groups. Gender distribution between groups was compared with Chi-Square test and SPSS 21 program wasused for calculations. The results were statistically significancant is p ˂0.05.Results: According to the findings obtained in this study antibodies revealed significantly higher staining in the oral squamouscell carcinoma group and leukoplakia group compared to with control groups.Conclusion: In this study, it was shown that EZH2, IGF-1R and Laminin-5 may have roles in cancer development.
AU  - Bektaş Kayhan, Kıvanç
AU  - GÜNER, Sevcihan
AU  - Başaran, Bora
AU  - Dolek Guler, Semra
AU  - Alatli, Fatma Canan
AU  - NAMDAR PEKİNER, FİLİZ
DO  - 10.17567/ataunidfd.890469
PY  - 2021
JO  - Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi
VL  - 31
IS  - 2
SN  - 1300-9044
SP  - 241
EP  - 246
DB  - TRDizin
UR  - http://search/yayin/detay/447370
ER  -