Aim: Lesions in the oral cavity are seen in a broad spectrum of diversity. Reactive proliferative lesions of soft tissue are comman oral lesions. The frequency of these lesions differs across various populations. This study aims to determine the distribution of the oral lesions by gender and age averages, and also to give an idea about the clinical manifestations, diagnosis and treatment process of these lesions. Materials and Methods: For this purpose, a clinical and pathological retrospective archive review has been performed covering between years 2010-2015. 268 biopsies and clinical datas of patients were studied and classified on the basis of their histopathologic diagnosis, age, gender and frequency. Results: Of 268 gingival biopsies, 117 (43.66%) cases were inflammatory fibrous hyperplasia, 58 (21.64%) were irritation fibroma, 29 (10.82%) were peripheral ossifying fibroma, 26 (9.70%) were peripheral giant cell granuloma, 17 (6.34%) were pyogenic granuloma, 12 (4.48%) were ligneous periodontitis, 7 (2.61%) were gingival fibromatosis, and 2 (0.75%) were juvenile hyaline fibromatosis. The lesions were more common in females (n=167, %62.31) than in males (n=101, %37.69). Gingiva with 206 (% 76.90) cases was the most frequent place of reactive lesions. Conclusion: The spectrum of determined lesions indicates that various diseases of oral pathology could hold periodontal tissues. Periodontists should not forget that they are the main responsible for the early diagnosis and treatment of these lesions. Preventing the delay of the diagnosis of serious lesions, guidance can be provided for the appropriate treatment.