TY  - JOUR
TI  - Investigation of Protecting Effect of Boric Acid against Mercury II Chloride Toxicity in Rat Brain Tissue
AB  - In this study, the protective effects of boric acid (BA) in the prevention of brain damagecaused by mercury II chloride ( HgCl2) in rats were investigated. In the experiment, 24 adult andWistar albino male rats weighing roundly 200-300 g were used. Group I (Control, n=8): Isotonicsaline (i.p), Group II (HgCl2,n=8):(0.01g/kg)(oral), Group III (HgCl2 + (BA) (n:8): HgCl2(0.01g/kg)+ BA (3.25mg/kg/day i.p.) group were administered. The rats in all groups were sacrificed at theend of the 10th day and their brain tissues were taken. Biochemical parameters including theenzyme activities of SOD, CAT and GSH-Px were measured. The enzyme activity of SOD wasreduced in HgCl2 treated group in comparison to the control group (p<0.001). Activity of theenzyme was increased after BA administration (p˂0.001). CAT enzyme activity decreased in HgCl2and HgCl2+BA administered groups with control (p˂0.001). An increase in enzyme activity in BAgroup with HgCl2 administered group was observed. GSH-Px enzyme activity decreased in HgCl2(p˂0.001) and HgCl2+BA (p˂0.05) groups with control. However, an increase was found in BAadministered group with HgCl2 administered group (p˂0.001). It is thought that antioxidant enzymeactivities such as SOD, CAT and GSH-Px are significantly changed and BA may have a protectiveeffect in the histopathological examination of brain tissue.
AU  - MELEK, SULE
AU  - ŞAHİN, Ömer
AU  - Ekin, Suat
AU  - AKKOYUN, Hurrem Turan
AU  - İZGİ, Mehmet Sait
AU  - bengü, aydın şükrü
AU  - ULUCAN, Aykut
AU  - Bayramoğlu AKKOYUN, Mahire
DO  - 10.46810/tdfd.819741
PY  - 2020
JO  - Türk Doğa ve Fen Dergisi
VL  - 9
IS  - 2
SN  - 2149-6366
SP  - 127
EP  - 133
DB  - TRDizin
UR  - http://search/yayin/detay/448306
ER  -