Ozone vs Melatonin: The Therapeutic Effects In Alcoholic Liver Disease
Yıl: 2020 Cilt: 17 Sayı: 1 Sayfa Aralığı: 133 - 139 Metin Dili: İngilizce DOI: 10.35440/hutfd.649302 İndeks Tarihi: 08-10-2021
Ozone vs Melatonin: The Therapeutic Effects In Alcoholic Liver Disease
Öz: Background: Alcoholic liver disease (ALD) is a worldwide health problem.Ozone and melatonin areagents that are widely used for their antioxidant properties in medical therapies.In this study, we aimedto evaluate the use of ozone and melatoninin ALD.Materials and Methods: Forty-eight rats were used, and ethanol, melatonin, and ozone wereadministrated. Histopathological evaluation was performed and activities of alanine aminotransferase(ALT), aspartate aminotransferase (AST), gamma glutamyl transferase (GGT) total antioxidant status(TAS), total oxidant status (TOS), and malondialdehyde (MDA)were determined in the blood samples,while TAS, TOS, and MDA parameters were measured in the liver tissue samples.Results: There were statistically significant differences between the studied groups concerning ALT,AST activities and TAS, TOS, and MDA levels. Vascular congestion, hepatocyte damage, periportalinflammation, and microvesicular steatosis were detected inthe alcohol-induced toxicity group.Conclusions: In the light of histopathological findings, we can claim that melatonin and ozoneadministrations are beneficial for alcohol-induced hepatotoxicity. However, ozone application issuperior to melatonin.
Anahtar Kelime: Ozon vs Melatonin: Alkolik Karaciğer Hastalığında Terapötik Etkileri
Öz: Amaç: Alkolik karaciğer hastalığı (ALD) dünya çapında bir sağlık sorunudur. Ozon ve melatonin tıbbi tedavilerdeki antioksidan özellikleri için yaygın olarak kullanılan ajanlardır. Biz bu çalışmada ALD’de ozon ve melatonin kullanımını değerlendirmeyi amaçladık. Materyal ve Metod: Kırk sekiz sıçan kullanılmış ve etanol, melatonin ve ozon uygulanmıştır. Histopatolojik değerlendirme yapılmıştır ve kanda alanin aminotransferaz (ALT), aspartat aminotransferaz (AST), gama glutamil transferaz (GGT), total antioksidan kapasite (TAK), total oksidan kapasite (TOK) ve malondialdehit (MDA); karaciğer dokusunda TAK, TOK ve MDA parametreleri ölçülmüştür. Bulgular: Çalışılan gruplar arasında ALT, AST aktiviteleri ve TAK, TOK ve MDA düzeyleri açısından istatistiksel olarak anlamlı fark vardı. Alkol kaynaklı toksisite grubunda vasküler konjesyon, hepatosit hasarı, periportal inflamasyon ve mikrovesiküler steatoz tespit edildi. Sonuç: Histopatolojik bulgular ışığında melatonin ve ozon uygulamalarının alkole bağlı hepatotoksisite için faydalı olduğunu iddia edebiliriz. Bununla birlikte, ozon uygulaması melatoninden daha üstündür.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | EROĞLU H, MAKAV M, Findik Guvendi G, Büyük B, Adali Y (2020). Ozone vs Melatonin: The Therapeutic Effects In Alcoholic Liver Disease. , 133 - 139. 10.35440/hutfd.649302 |
| Chicago | EROĞLU Huseyin Avni,MAKAV MUSTAFA,Findik Guvendi Gulname,Büyük Başak,Adali Yasemen Ozone vs Melatonin: The Therapeutic Effects In Alcoholic Liver Disease. (2020): 133 - 139. 10.35440/hutfd.649302 |
| MLA | EROĞLU Huseyin Avni,MAKAV MUSTAFA,Findik Guvendi Gulname,Büyük Başak,Adali Yasemen Ozone vs Melatonin: The Therapeutic Effects In Alcoholic Liver Disease. , 2020, ss.133 - 139. 10.35440/hutfd.649302 |
| AMA | EROĞLU H,MAKAV M,Findik Guvendi G,Büyük B,Adali Y Ozone vs Melatonin: The Therapeutic Effects In Alcoholic Liver Disease. . 2020; 133 - 139. 10.35440/hutfd.649302 |
| Vancouver | EROĞLU H,MAKAV M,Findik Guvendi G,Büyük B,Adali Y Ozone vs Melatonin: The Therapeutic Effects In Alcoholic Liver Disease. . 2020; 133 - 139. 10.35440/hutfd.649302 |
| IEEE | EROĞLU H,MAKAV M,Findik Guvendi G,Büyük B,Adali Y "Ozone vs Melatonin: The Therapeutic Effects In Alcoholic Liver Disease." , ss.133 - 139, 2020. 10.35440/hutfd.649302 |
| ISNAD | EROĞLU, Huseyin Avni vd. "Ozone vs Melatonin: The Therapeutic Effects In Alcoholic Liver Disease". (2020), 133-139. https://doi.org/10.35440/hutfd.649302 |
| APA | EROĞLU H, MAKAV M, Findik Guvendi G, Büyük B, Adali Y (2020). Ozone vs Melatonin: The Therapeutic Effects In Alcoholic Liver Disease. Harran Üniversitesi Tıp Fakültesi Dergisi, 17(1), 133 - 139. 10.35440/hutfd.649302 |
| Chicago | EROĞLU Huseyin Avni,MAKAV MUSTAFA,Findik Guvendi Gulname,Büyük Başak,Adali Yasemen Ozone vs Melatonin: The Therapeutic Effects In Alcoholic Liver Disease. Harran Üniversitesi Tıp Fakültesi Dergisi 17, no.1 (2020): 133 - 139. 10.35440/hutfd.649302 |
| MLA | EROĞLU Huseyin Avni,MAKAV MUSTAFA,Findik Guvendi Gulname,Büyük Başak,Adali Yasemen Ozone vs Melatonin: The Therapeutic Effects In Alcoholic Liver Disease. Harran Üniversitesi Tıp Fakültesi Dergisi, vol.17, no.1, 2020, ss.133 - 139. 10.35440/hutfd.649302 |
| AMA | EROĞLU H,MAKAV M,Findik Guvendi G,Büyük B,Adali Y Ozone vs Melatonin: The Therapeutic Effects In Alcoholic Liver Disease. Harran Üniversitesi Tıp Fakültesi Dergisi. 2020; 17(1): 133 - 139. 10.35440/hutfd.649302 |
| Vancouver | EROĞLU H,MAKAV M,Findik Guvendi G,Büyük B,Adali Y Ozone vs Melatonin: The Therapeutic Effects In Alcoholic Liver Disease. Harran Üniversitesi Tıp Fakültesi Dergisi. 2020; 17(1): 133 - 139. 10.35440/hutfd.649302 |
| IEEE | EROĞLU H,MAKAV M,Findik Guvendi G,Büyük B,Adali Y "Ozone vs Melatonin: The Therapeutic Effects In Alcoholic Liver Disease." Harran Üniversitesi Tıp Fakültesi Dergisi, 17, ss.133 - 139, 2020. 10.35440/hutfd.649302 |
| ISNAD | EROĞLU, Huseyin Avni vd. "Ozone vs Melatonin: The Therapeutic Effects In Alcoholic Liver Disease". Harran Üniversitesi Tıp Fakültesi Dergisi 17/1 (2020), 133-139. https://doi.org/10.35440/hutfd.649302 |
