The anticancer activity of chalcone compounds against human prostate carcinoma cell and human colon colorectal adenocarcinoma
Yıl: 2021 Cilt: 5 Sayı: 1 Sayfa Aralığı: 52 - 58 Metin Dili: İngilizce DOI: 10.32571/ijct.910580 İndeks Tarihi: 29-07-2022
The anticancer activity of chalcone compounds against human prostate carcinoma cell and human colon colorectal adenocarcinoma
Öz: Cancer is the second most common cause of death in ourcountry and also worldwide. In the cancer treatment are usedmany methods such as surgery, chemotherapy, radiotherapyand hormone therapy. Despite these methods, a decrease is notobserved in cancer cases and in the mortality. In addition,cancer drugs cause serious side effects. Therefore, there is aneed for new anticancer drugs. Chalcones have broadanticancer activity against various cancer cells. In this study,the anticancer activities of the chalcone compounds wereinvestigated against PC3 (Human Prostate Carcinoma Cell) andHT29 (Human colon colorectal adenocarcinoma) cell lines. Theanticancer activity tests were performed using the BrdU ELISAmethod. 5-Fluorouracil (5-FU) was used as the positive control.Compound 1-7 (except Compound 3) were determined havinghigher anticancer activity than 5-FU against PC3 cancer cells.IC50 values of the compounds 1-7 against PC3 cancer cells were2.53±0.02 µM; 4.40±0.03 µM; 5.86±0.02 µM; 4.36±0.03 µM;1.76±0.02 µM; 1.78±0.03 µM; 2.31±0.03 µM, respectively.
Anahtar Kelime: Kalkon bileşiklerinin insan prostat karsinom hücresi ve kolon kolorektal adenokarsinomuna karşı antikanser aktivitesi
Öz: Kanser, ülkemizde ve dünya çapında en yaygın ikinci ölüm nedenidir. Kanser tedavisinde ameliyat, kemoterapi, radyoterapi ve hormon tedavisi gibi birçok yöntem kullanılmaktadır. Bu yöntemlere rağmen kanser vakalarında ve ölümlerde azalma gözlenmemektedir. Ayrıca kanser ilaçları ciddi yan etkilere neden olur. Bu nedenle yeni antikanser ilaçlara ihtiyaç vardır. Kalkonlar, çeşitli kanser hücrelerine karşı geniş bir antikanser aktivitesine sahiptir. Bu çalışmada kalkon türevlerinin antikanser aktiviteleri PC3 (insan prostat karsinom hücresi) ve HT29 (İnsan kolon kolorektal adenokarsinom) hücre hatlarına karşı araştırılmıştır. Antikanser aktivite testleri BrdU ELISA yöntemi kullanılarak yapıldı. Pozitif kontrol olarak 5-Florourasil (5-FU) kullanıldı. Bileşik 1- 7 (Bileşik 3 hariç), PC3 kanser hücrelerine karşı 5-FU'dan daha yüksek antikanser aktiviteye sahip olduğu belirlendi. Bileşik 1- 7'nin PC3 kanser hücrelerine karşı IC50 değerleri sırasıyla, 2.53±0.02 µM; 4.40±0.03 µM; 5.86±0.02 µM; 4.36±0.03 µM; 1.76±0.02 µM; 1.78±0.03 µM; 2.31±0.03 µM’dı.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | KURSUN AKTAR B, Sahin Yaglioglu A, oruç-emre e (2021). The anticancer activity of chalcone compounds against human prostate carcinoma cell and human colon colorectal adenocarcinoma. , 52 - 58. 10.32571/ijct.910580 |
| Chicago | KURSUN AKTAR BEDRİYE SEDA,Sahin Yaglioglu Ayse,oruç-emre emine elçin The anticancer activity of chalcone compounds against human prostate carcinoma cell and human colon colorectal adenocarcinoma. (2021): 52 - 58. 10.32571/ijct.910580 |
| MLA | KURSUN AKTAR BEDRİYE SEDA,Sahin Yaglioglu Ayse,oruç-emre emine elçin The anticancer activity of chalcone compounds against human prostate carcinoma cell and human colon colorectal adenocarcinoma. , 2021, ss.52 - 58. 10.32571/ijct.910580 |
| AMA | KURSUN AKTAR B,Sahin Yaglioglu A,oruç-emre e The anticancer activity of chalcone compounds against human prostate carcinoma cell and human colon colorectal adenocarcinoma. . 2021; 52 - 58. 10.32571/ijct.910580 |
| Vancouver | KURSUN AKTAR B,Sahin Yaglioglu A,oruç-emre e The anticancer activity of chalcone compounds against human prostate carcinoma cell and human colon colorectal adenocarcinoma. . 2021; 52 - 58. 10.32571/ijct.910580 |
| IEEE | KURSUN AKTAR B,Sahin Yaglioglu A,oruç-emre e "The anticancer activity of chalcone compounds against human prostate carcinoma cell and human colon colorectal adenocarcinoma." , ss.52 - 58, 2021. 10.32571/ijct.910580 |
| ISNAD | KURSUN AKTAR, BEDRİYE SEDA vd. "The anticancer activity of chalcone compounds against human prostate carcinoma cell and human colon colorectal adenocarcinoma". (2021), 52-58. https://doi.org/10.32571/ijct.910580 |
| APA | KURSUN AKTAR B, Sahin Yaglioglu A, oruç-emre e (2021). The anticancer activity of chalcone compounds against human prostate carcinoma cell and human colon colorectal adenocarcinoma. International Journal of Chemistry and Technology (IJCT), 5(1), 52 - 58. 10.32571/ijct.910580 |
| Chicago | KURSUN AKTAR BEDRİYE SEDA,Sahin Yaglioglu Ayse,oruç-emre emine elçin The anticancer activity of chalcone compounds against human prostate carcinoma cell and human colon colorectal adenocarcinoma. International Journal of Chemistry and Technology (IJCT) 5, no.1 (2021): 52 - 58. 10.32571/ijct.910580 |
| MLA | KURSUN AKTAR BEDRİYE SEDA,Sahin Yaglioglu Ayse,oruç-emre emine elçin The anticancer activity of chalcone compounds against human prostate carcinoma cell and human colon colorectal adenocarcinoma. International Journal of Chemistry and Technology (IJCT), vol.5, no.1, 2021, ss.52 - 58. 10.32571/ijct.910580 |
| AMA | KURSUN AKTAR B,Sahin Yaglioglu A,oruç-emre e The anticancer activity of chalcone compounds against human prostate carcinoma cell and human colon colorectal adenocarcinoma. International Journal of Chemistry and Technology (IJCT). 2021; 5(1): 52 - 58. 10.32571/ijct.910580 |
| Vancouver | KURSUN AKTAR B,Sahin Yaglioglu A,oruç-emre e The anticancer activity of chalcone compounds against human prostate carcinoma cell and human colon colorectal adenocarcinoma. International Journal of Chemistry and Technology (IJCT). 2021; 5(1): 52 - 58. 10.32571/ijct.910580 |
| IEEE | KURSUN AKTAR B,Sahin Yaglioglu A,oruç-emre e "The anticancer activity of chalcone compounds against human prostate carcinoma cell and human colon colorectal adenocarcinoma." International Journal of Chemistry and Technology (IJCT), 5, ss.52 - 58, 2021. 10.32571/ijct.910580 |
| ISNAD | KURSUN AKTAR, BEDRİYE SEDA vd. "The anticancer activity of chalcone compounds against human prostate carcinoma cell and human colon colorectal adenocarcinoma". International Journal of Chemistry and Technology (IJCT) 5/1 (2021), 52-58. https://doi.org/10.32571/ijct.910580 |
