Seismic design codes limit the inter-story drifts of buildings to protect the non-structural components and tominimize the secondary effects of gravity loads. A new version of Turkish Building Earthquake Code(TBEC, 2018) is in act starting from 2019 by replacing the former version of the Turkish Earthquake Code(TEC, 2007). One of the significant changes in TBEC (2018) is the definition of the inter-story drift ratio(ISDR) limit. The ISDR is limited by 2% as per TEC (2007) without considering any other criteria. However,the ISDR limit of TBEC (2018) is modified by considering several parameters. The type of building(reinforced concrete (RC) or steel), the interaction of infill walls with the neighbouring structural componentsand the ratio of spectral ordinates at the fundamental period of the building of 72-year return periodearthquake to 475-year return period earthquake (λ) are the three important parameters. Moreover, effectiverigidities of RC members should be adopted in TBEC (2018). Change in ISDR demands and correspondinglimits specified by the two versions of the earthquake code are examined for a 6-story RC building.Moreover, the variation in the ratio of spectral ordinates (λ) and ISDR limit are investigated for 105 pointsmainly in the Marmara Region. The comparisons are conducted for five different local site conditions (ZAto ZE). The change in the ISDR limits is considerable, especially for the poor soil conditions. Moreover, theinteraction of infill walls with the structural components has a direct influence on the ISDR limits.