The Effects of Agomelatine Treatment on Lipopolysaccharide-Induced Septic Lung Injuries in Rats

KOSE, DUYGU; CADIRCI, ELIF; GÜRBÜZ, Muhammed; HALICI, Zekai; YÜKSEL, Tuğba Nurcan

The Effects of Agomelatine Treatment on Lipopolysaccharide-Induced Septic Lung Injuries in Rats

Duygu Köse, (Klinik Araştırma, Geliştirme ve Tasarım Uygulama ve Araştırma Merkezi, Atatürk Üniversite, Erzurum)

Tuğba Nurcan Yüksel, (Farmakoloji Anabilim Dalı, Namık Kemal Üniversite Tıp Fakültesi, Tekirdağ, Türkiye)

Zekai Halıcı, (Klinik Araştırma, Geliştirme ve Tasarım Uygulama ve Araştırma Merkezi, Atatürk Üniversite, Erzurum)

Elif Çadırcı, (Farmakoloji Anabilim Dalı, Atatürk Üniversite Tıp Fakültesi, Erzurum, Türkiye)

Muhammet Ali GÜRBÜZ (Histoloji ve Embriyoloji Anabilim Dalı, Atatürk Üniversitesi Tıp Fakültesi, Erzurum, Türkiye)

Eurasian Journal of Medicine

2 0

Yıl: 2021 Cilt: 53 Sayı: 2 Sayfa Aralığı: 127 - 131 Metin Dili: İngilizce İndeks Tarihi: 09-10-2021

The Effects of Agomelatine Treatment on Lipopolysaccharide-Induced Septic Lung Injuries in Rats

Öz:

Objective: We designed an experimental model of sepsis in rats to investigate the effects of agomelatine(AGO) on lung tissues using molecular and histopathological methods.Materials and Methods: In our experimental model, the 32 rats were divided into 4 groups: group 1: controlgroup (HEALTHY); group 2: lipopolysaccharide group (LPS); group 3: LPS plus 50 mg/kg AGO group (LPS +AGO50); and group 4: LPS plus 100 mg/kg AGO group (LPS + AGO100). An LPS-induced sepsis model wasperformed to replicate the pathology of sepsis. Rats from all 4 groups were killed after 12 hours, and theirlungs were quickly collected. To investigate the therapeutic strategy, we evaluated tumor necrosis factoralpha (TNF-α) and nuclear factor-kappa B (NF-κB) messenger RNA expressions by real-time polymerasechain reaction using molecular methods and lung tissue damage indicators using histopathological methods.Results: The expressions of TNF-α and NF-κB were reduced in the groups treated with AGO. The histopathology results supported the molecular results.Conclusion: In this experimental study, we demonstrated for the first time the positive effects of AGO onLPS-induced sepsis in lung tissue using molecular and histopathological methods, indicating that it contributesto the prevention of lung damage

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APA	KOSE D, YÜKSEL T, HALICI Z, CADIRCI E, GÜRBÜZ M (2021). The Effects of Agomelatine Treatment on Lipopolysaccharide-Induced Septic Lung Injuries in Rats. , 127 - 131.
Chicago	KOSE DUYGU,YÜKSEL Tuğba Nurcan,HALICI Zekai,CADIRCI ELIF,GÜRBÜZ Muhammed The Effects of Agomelatine Treatment on Lipopolysaccharide-Induced Septic Lung Injuries in Rats. (2021): 127 - 131.
MLA	KOSE DUYGU,YÜKSEL Tuğba Nurcan,HALICI Zekai,CADIRCI ELIF,GÜRBÜZ Muhammed The Effects of Agomelatine Treatment on Lipopolysaccharide-Induced Septic Lung Injuries in Rats. , 2021, ss.127 - 131.
AMA	KOSE D,YÜKSEL T,HALICI Z,CADIRCI E,GÜRBÜZ M The Effects of Agomelatine Treatment on Lipopolysaccharide-Induced Septic Lung Injuries in Rats. . 2021; 127 - 131.
Vancouver	KOSE D,YÜKSEL T,HALICI Z,CADIRCI E,GÜRBÜZ M The Effects of Agomelatine Treatment on Lipopolysaccharide-Induced Septic Lung Injuries in Rats. . 2021; 127 - 131.
IEEE	KOSE D,YÜKSEL T,HALICI Z,CADIRCI E,GÜRBÜZ M "The Effects of Agomelatine Treatment on Lipopolysaccharide-Induced Septic Lung Injuries in Rats." , ss.127 - 131, 2021.
ISNAD	KOSE, DUYGU vd. "The Effects of Agomelatine Treatment on Lipopolysaccharide-Induced Septic Lung Injuries in Rats". (2021), 127-131.

APA	KOSE D, YÜKSEL T, HALICI Z, CADIRCI E, GÜRBÜZ M (2021). The Effects of Agomelatine Treatment on Lipopolysaccharide-Induced Septic Lung Injuries in Rats. Eurasian Journal of Medicine, 53(2), 127 - 131.
Chicago	KOSE DUYGU,YÜKSEL Tuğba Nurcan,HALICI Zekai,CADIRCI ELIF,GÜRBÜZ Muhammed The Effects of Agomelatine Treatment on Lipopolysaccharide-Induced Septic Lung Injuries in Rats. Eurasian Journal of Medicine 53, no.2 (2021): 127 - 131.
MLA	KOSE DUYGU,YÜKSEL Tuğba Nurcan,HALICI Zekai,CADIRCI ELIF,GÜRBÜZ Muhammed The Effects of Agomelatine Treatment on Lipopolysaccharide-Induced Septic Lung Injuries in Rats. Eurasian Journal of Medicine, vol.53, no.2, 2021, ss.127 - 131.
AMA	KOSE D,YÜKSEL T,HALICI Z,CADIRCI E,GÜRBÜZ M The Effects of Agomelatine Treatment on Lipopolysaccharide-Induced Septic Lung Injuries in Rats. Eurasian Journal of Medicine. 2021; 53(2): 127 - 131.
Vancouver	KOSE D,YÜKSEL T,HALICI Z,CADIRCI E,GÜRBÜZ M The Effects of Agomelatine Treatment on Lipopolysaccharide-Induced Septic Lung Injuries in Rats. Eurasian Journal of Medicine. 2021; 53(2): 127 - 131.
IEEE	KOSE D,YÜKSEL T,HALICI Z,CADIRCI E,GÜRBÜZ M "The Effects of Agomelatine Treatment on Lipopolysaccharide-Induced Septic Lung Injuries in Rats." Eurasian Journal of Medicine, 53, ss.127 - 131, 2021.
ISNAD	KOSE, DUYGU vd. "The Effects of Agomelatine Treatment on Lipopolysaccharide-Induced Septic Lung Injuries in Rats". Eurasian Journal of Medicine 53/2 (2021), 127-131.