Investıgation of The Effect of Multiple Sclerosis on Peripheral Nerves

Gökpınar, Gökhan; Çağaç, Aydın; Milanlıoğlu, Aysel

doi:10.5505/ejm.2021.87846

Investıgation of The Effect of Multiple Sclerosis on Peripheral Nerves

Gökhan GÖKPİNAR, (Van Yüzüncü Yıl Üniversitesi, Tıp Fakültesi, Van, Türkiye)

Aydın ÇAĞAÇ, (Van Yüzüncü Yıl Üniversitesi, Tıp Fakültesi, Van, Türkiye)

Aysel MİLANLİOĞLU (Van Yüzüncü Yıl Üniversitesi, Tıp Fakültesi, Van, Türkiye)

Eastern Journal of Medicine

2 0

Yıl: 2021 Cilt: 26 Sayı: 3 Sayfa Aralığı: 481 - 486 Metin Dili: İngilizce DOI: 10.5505/ejm.2021.87846 İndeks Tarihi: 09-10-2021

Investıgation of The Effect of Multiple Sclerosis on Peripheral Nerves

Öz:

Multiple sclerosis is an autoimmune central nervous system disease characterized by inflammation, demyelination and axondamage. The aim of this study was to determine peripheral nerve involvement and related factors in patients with multiplesclerosis.In our study, 35 (70.0%) of the patients were suffering from Relapsing Remitting Multiple Sclerosis, and 15 (30.0%) ofthem had Secondary Progressive Multiple Sclerosis. The mean age of the symptom onset of the disease in patients was30.44 ± 1.06 years, the mean score of the Multiple Sclerosis Disability Scale (EDDS) was 2.97 ± 2.58 pointsPolyneuropatia was detected in 12 (24.0%) patients. Polyneuropathy was detected in 3 patients (6.0%) in the contr ol group.In our study, peripheral nerve involvement was higher in male patients than female patients. There was a very strongpositive correlation between the duration of disease development and the Extended Multiple Sclerosis Disability Scalescores.In the study, it was determined that multiple sclerosis was more commonly seen in women in accordance with theliterature, and EDDS scores increased as the disease duration increased.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

1. Lassmann H, Brück W, Lucchinetti CF. The immunopathology of multiple sclerosis: an overview. Brain Pathology 2007; 17: 210-218.
2. 2-Lassmann H. Mechanisms of inflammation induced tissue injury in multiple sclerosis. Journal of the Neurological Sciences 2008; 274: 45-47.
3. Fabis-Pedrini MJ, James I, Seewann A, et al. Natural history of benign multiple sclerosis: Clinical and HLA correlates in a Western Australian cohort.J Neurol Sci 2018; 388: 12- 18.
4. McAlpine D, Compston A. McAlpine's multiple sclerosis: Elsevier Health Sciences; 2005.
5. Stadelmann C. Multiple sclerosis as a neurodegenerative disease: pathology, mechanisms and therapeutic implications. Curr Opin Neurol 2011; 24: 224-229.
6. Melzer N, Meuth S. G. Department of Neurology, University of Münster, Münster, Germany
7. Biomed Res Int.2013; 2013: 847670. doi:10.1155/2013/847670.Epub2013 Nov7.Abnormal nerve conduction study findings indicating the existence of peripheral neuropathy in multiple sclerosis and neuromyelitis optica. Warabi
8. Kabat EA, Freedman DA. A study of the crystalline albumin, gammaglobulin and total protein in the cerebrospinal fluid of 100 cases of multiple sclerosis and in other diseases. Am J Med Sci 1950; 219: 55-64.
9. Racke MK. The role of B cells in multiple sclerosis: rationale for B-cell targe ted therapies. Curr Opin Neurol 2008; 21: 9-18.
10. Haraiti Y, Varlı K. Perifeik sinir hastalıkları, in neurology clinical practice-Türkçe, eds. Tan R, Özdamar SE, 5. Baskı, Veri Medikal Yayıncılık, Ankara 2008; 2249-356.
11. Zembilci N. Kızıltan M. Sinir Sistemi Hastalıkları. Ed.3.1994. Cerrahpaşa Tıp Fak. Syf. 267. Neurology in clinical neurology.
12. Gooch CL, Weimer LH. The electrodiagnosis of neuropathy:basic principles and common pitfalls. Neurol Clin 2007; 25: 1-28.
13. Atila N, Çilingir V. Comparison of Upper and Lower Extremity Functions in Primary and Secondary Progressive Multiple Sclerosis Patients. Van Yüzüncü Yıl University Faculty of Medicine, Department of Neurology, Unpublished Medical Specialization Thesis, 2018.
14. Kister et al. Natural History of Multiple Sclerosis Symptoms. International Journal of MS Care 2013; 15: 146-158.
15. Baklacıoğlu et al. Relationship between extended state disability scale and anxiety depression in patients with multiple sclerosis. Göztepe Medical Journal 2009; 24: 178-182.
16. Brola et al. Prevalence and incidence of multiple sclerosis in central Poland, BMC Neurology 2016; 16: 134.
17. Kaya Aygunoglu et al. The Relationship of Fatigue with Depression, Disability and Quality of Life in Multiple Sclerosis Patients. Arch Neuropsychiatr 2015; 52: 247-251.
18. Pittock SJ, Mayr WT, McClelland R, et all: Disability profile of MS cohort, Neurology 2004; 62: 601.
19. Sarova Pinhas et al. Peripheral neuropathy in multiple sclerosis: a clinical and electrophysiologic study. Acta Neural Scand 1995; 91: 234-238.
20. Hanewinckel et al. The epidemiology and risk factors of chronic polyneuropathy Eur J Epidemiol 2016; 31: 5-20.
21. Burns TM, Baurmann ML The Evaluation of Polyneuropathies. Neurology 2011; 76.
22. Emad MR, Zeinali L, Nikseresht A, Naseri M, Karimian H. Peripheral Neuropathy in Multiple Sclerosis: An Electrophysiologic Study in Iranian Patients. Acta Med Iran 2017; 55: 496-501.
23. Misawa S, Kuwabara S, Mori M, Hayakawa S, Sawai S, Hattori T. Peripheral nerve demyelination in multiple sclerosis. Clin Neurophysiol 2008; 119: 1829-1833.
24. Thompson AJ, Baranzini SE, Geurts J, Hemmer B, Ciccarelli O. Multiple sclerosis. The Lancet 2018; 391: 1622-1636.

APA	Gökpınar G, Çağaç A, Milanlıoğlu A (2021). Investıgation of The Effect of Multiple Sclerosis on Peripheral Nerves. , 481 - 486. 10.5505/ejm.2021.87846
Chicago	Gökpınar Gökhan,Çağaç Aydın,Milanlıoğlu Aysel Investıgation of The Effect of Multiple Sclerosis on Peripheral Nerves. (2021): 481 - 486. 10.5505/ejm.2021.87846
MLA	Gökpınar Gökhan,Çağaç Aydın,Milanlıoğlu Aysel Investıgation of The Effect of Multiple Sclerosis on Peripheral Nerves. , 2021, ss.481 - 486. 10.5505/ejm.2021.87846
AMA	Gökpınar G,Çağaç A,Milanlıoğlu A Investıgation of The Effect of Multiple Sclerosis on Peripheral Nerves. . 2021; 481 - 486. 10.5505/ejm.2021.87846
Vancouver	Gökpınar G,Çağaç A,Milanlıoğlu A Investıgation of The Effect of Multiple Sclerosis on Peripheral Nerves. . 2021; 481 - 486. 10.5505/ejm.2021.87846
IEEE	Gökpınar G,Çağaç A,Milanlıoğlu A "Investıgation of The Effect of Multiple Sclerosis on Peripheral Nerves." , ss.481 - 486, 2021. 10.5505/ejm.2021.87846
ISNAD	Gökpınar, Gökhan vd. "Investıgation of The Effect of Multiple Sclerosis on Peripheral Nerves". (2021), 481-486. https://doi.org/10.5505/ejm.2021.87846

APA	Gökpınar G, Çağaç A, Milanlıoğlu A (2021). Investıgation of The Effect of Multiple Sclerosis on Peripheral Nerves. Eastern Journal of Medicine, 26(3), 481 - 486. 10.5505/ejm.2021.87846
Chicago	Gökpınar Gökhan,Çağaç Aydın,Milanlıoğlu Aysel Investıgation of The Effect of Multiple Sclerosis on Peripheral Nerves. Eastern Journal of Medicine 26, no.3 (2021): 481 - 486. 10.5505/ejm.2021.87846
MLA	Gökpınar Gökhan,Çağaç Aydın,Milanlıoğlu Aysel Investıgation of The Effect of Multiple Sclerosis on Peripheral Nerves. Eastern Journal of Medicine, vol.26, no.3, 2021, ss.481 - 486. 10.5505/ejm.2021.87846
AMA	Gökpınar G,Çağaç A,Milanlıoğlu A Investıgation of The Effect of Multiple Sclerosis on Peripheral Nerves. Eastern Journal of Medicine. 2021; 26(3): 481 - 486. 10.5505/ejm.2021.87846
Vancouver	Gökpınar G,Çağaç A,Milanlıoğlu A Investıgation of The Effect of Multiple Sclerosis on Peripheral Nerves. Eastern Journal of Medicine. 2021; 26(3): 481 - 486. 10.5505/ejm.2021.87846
IEEE	Gökpınar G,Çağaç A,Milanlıoğlu A "Investıgation of The Effect of Multiple Sclerosis on Peripheral Nerves." Eastern Journal of Medicine, 26, ss.481 - 486, 2021. 10.5505/ejm.2021.87846
ISNAD	Gökpınar, Gökhan vd. "Investıgation of The Effect of Multiple Sclerosis on Peripheral Nerves". Eastern Journal of Medicine 26/3 (2021), 481-486. https://doi.org/10.5505/ejm.2021.87846