Deneysel Beyin Yaralanma Modelleri

Kanat, Ayhan; Ozdemir, Bulent; Kazdal, Hizir

Deneysel Beyin Yaralanma Modelleri

Bülent ÖZDEMIR, (Recep Tayyip Erdoğan Üniversitesi, Tıp Fakültesi, Nöroşirürji Anabilim Dalı, Rize, Türkiye)

Ayhan KANAT, (Recep Tayyip Erdoğan Üniversitesi, Tıp Fakültesi, Nöroşirürji Anabilim Dalı, Rize, Türkiye)

Hızır KAZDAL (Recep Tayyip Erdoğan Üniversitesi, Tıp Fakültesi, Anestezi ve Reanimasyon Anabilim Dalı, Rize, Türkiye)

Türk Nöroşirürji Dergsi

3 0

Yıl: 2020 Cilt: 30 Sayı: 2 Sayfa Aralığı: 308 - 311 Metin Dili: Türkçe İndeks Tarihi: 10-10-2021

Deneysel Beyin Yaralanma Modelleri

Öz:

Travmatik beyin hasarları, toplumda her yaş grubunda görülebilen önemli bir toplum sağlığı sorunudur. En sık sebepler, trafikkazası, yüksekten düşmedir. Bu tür yaralanmalar sonucunda, intrakranial kanama oluşabildiğinden, yüksek mortalite ve morbiditeyeneden olabilirler. Travma beynin kafatası içinde ani hareketine ve kafatası yaralanması ile birlikte beynin hasarlanmasına nedenolur. Yaralanma birincil ya da ikincil olabilir. Birincil yaralanma, dış travmanın ani etkisi ile olur. Yapılan çalışmalar birincil beyinyaralanmasından saatler sonra bile hücre ölümlerinin başladığını göstermektedir. Burada kontüzyon, kanama, aksonal hasarlanmaolabilir. İkincil yaralanma, primer yaralanmadan dakikalar, hatta aylar sonra gelişir. Bu tür yaralanmaların, biyomekanik, moleküler,hücresel etkilerini anlayabilmek için deney hayvanlarında bu tür yaralanma modelleri kullanılır. Çalışmanın amacı, kullanılan hayvanmodellerinin incelenmesidir.

Anahtar Kelime:

Experimental Cerebral Injury Models

Öz:

Traumatic brain injuries are an important public health problem that can be seen in any age group in the community. The most common causes are traffic accidents and falling from heights. As a result of such injuries, intracranial hemorrhage with high mortality and morbidity may occur. Trauma causes sudden movement of the brain within the skull. The injury can be primary or secondary. Primary injury happens with the sudden effect of external trauma. Studies have shown that cell death can begin even hours after the primary brain injury. There may also be contusion, bleeding, and axonal damage. Secondary injury can develop minutes or even months after the primary injury. In order to understand the biomechanical, molecular and cellular effects of such injuries, several injury models have been used in experimental studies. The aim of the present study is to review these animal models.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Derleme Erişim Türü: Erişime Açık

1. Armstrong R, Xu F, Arora A, Rasic N, Syed NI: General anesthetics and cytotoxicity: Possible implications for brain health. Drug Chem Toxicol 40:241-249, 2017
2. Bahmad HF, Darwish B, Dargham KB, Machmouchi R, Dargham BB, Osman M, Khechen Z Al, El Housheimi N, Abou-Kheir W, Chamaa F: Role of MicroRNAs in anesthesiainduced neurotoxicity in animal models and neuronal cultures: A systematic review. Neurotox Res 37:479-490, 2020
3. Bolouri H, Zetterberg H: Animal models for concussion: Molecular and cognitive assessments-relevance to sport and military concussions. In: Kobeissy FH (ed). Source Brain Neurotrauma: Molecular, Neuropsychological, and Rehabilitation Aspects. Boca Raton (FL): CRC Press/Taylor & Francis, 2015:Chapter 46
4. Cavusoglu H, Genc HA, Aydin Y: The efficacy of decompressive craniectomy in the treatment of traumatic severe brain injury. Türk Nöroşirürji Derg 15:161-168, 2005
5. Celiker M, Kanat A, Ozdemir A, Celiker FB, Kazdal H, Ozdemir B, Batcik OE, Ozdemir D: Controversy about the protective role of volume in the frontal sinus after severe head trauma: Larger sinus equates with higher risk of death. Br J Oral Maxillofac Surg 58(3):314-318, 2020
6. Celiker M, Kanat A, Aydin MD, Ozdemir D, Aydin N, Yolas C, Calik M, Peker HO: First emerging objective experimental evidence of hearing impairment following subarachnoid haemorrhage; Felix culpa, phonophobia, and elucidation of the role of trigeminal ganglion. Int J Neurosci 129:794-800, 2019
7. Cikriklar HI, Uysal O, Ekici MA, Ozbek Z, Cosan DT, Yucel M, Yurumez Y, Baydemir C: Effectiveness of GFAP in determining neuronal damage in rats with ınduced head trauma. Turk Neurosurg 26:878-889, 2016
8. Dixon CE, Clifton GL, Lighthall JW, Yaghmai AA, Hayes RL: A controlled cortical impact model of traumatic brain injury in the rat. J Neurosci Methods 39:253-262, 1991
9. Donnarumma P, Tarantino R, Gennaro P, Mitro V, Valentini V, Magliulo G, Delfini R: Penetrating gunshot wound to the head: Transotic approach to remove the bullet and masseteric-facial nerve anastomosis for early facial reanimation. Turk Neurosurg 24:415-418, 2014
10. Feeney DM, Boyeson MG, Linn RT, Murray HM, Dail WG: Responses to cortical injury: I. Methodology and local effects of contusions in the rat. Brain Res 211:67-77, 1981
11. Gurer B, Kertmen H, Yilmaz ER, Dolgun H, Hasturk AE, Sekerci Z: The surgical outcome of traumatic extraaxial hematomas causing brain herniation. Turk Neurosurg 27:37-52, 2017
12. Jiang J, Dai C, Niu X, Sun H, Cheng S, Zhang Z, Zhu X, Wang Y, Zhang T, Duan F, Chen X, Zhang S: Establishment of a precise novel brain trauma model in a large animal based on injury of the cerebral motor cortex. J Neurosci Methods 307:95-105, 2018
13. Kanat A: Brain oxygenation and energy metabolism: Part I - Biological function and pathophysiology. Neurosurgery 52(6):1508-1509, 2003
14. Kanat A, Aydin Y: Postcontrast magnetic resonance imaging to predict progression of traumatic epidural and subdural hematomas in the acute stage. Neurosurgery 44(3):685, 1999
15. Kanat A, Aydin Y: Prognostic value and determinants of ultraearly angiographic vasospasm after aneurysmal subarachnoid hemorrhage. Neurosurgery 46:505–507, 2000
16. Kazdal H, Kanat A, Aydin MD, Yazar U, Guvercin AR, Calik M, Gundogdu B: Sudden death and cervical spine: A new contribution to pathogenesis for sudden death in critical care unit from subarachnoid hemorrhage; first report–An experimental study. J Craniovertebr Junction Spine 8:33, 2017
17. Kose G, Ayhan H: Travmatik beyin yaralanmalarında beslenme. Türk Nöroşirurji Derg 28:386-392, 2018
18. Marmarou A, Foda MA, van den Brink W, Campbell J, Kita H, Demetriadou K: A new model of diffuse brain injury in rats. Part I: Pathophysiology and biomechanics. J Neurosurg 80:291-300, 1994
19. Ozdemir B, Kanat A, Batcik S, Batcik OE, Celiker M, Kayayurt K: Unilateral isolated hypoglossal nerve palsy caused by gunshot injury. J Craniofac Surg 29:424-426, 2018
20. Ozdemir M, Unlu A: Gunshot injuries due to celebratory gun shootings. Turk Neurosurg 19:73-76, 2009
21. Simsek M, Kaya M, Hicdonmez T, Suslu HT, Gergin YE: Travmaya bağlı gelişen kafa kemik kırıklarının epidemiyolojisi ve prognostik faktörlerinin belirlenmesi. Türk Nöroşirürji Derg 23:12-17, 2013
22. Sullivan HG, Martinez J, Becker DP, Miller JD, Griffith R, Wist AO: Fluid-percussion model of mechanical brain injury in the cat. J Neurosurg 45:521-534, 1976
23. Temiz NC, Kose G, Tehli O, Acikel C, Hatipoglu S: A comparison between the effectiveness of full outline of unresponsiveness and glasgow coma score at neurosurgical intensive care unit patients. Turk Neurosurg 28:248-250, 2018
24. Umerani MS, Abbas A, Sharif S: Traumatic brain injuries: Experience from a tertiary care centre in Pakistan. Turk Neurosurg 24:19-24, 2014
25. Xiong Y, Mahmood A, Chopp M: Animal models of traumatic brain injury. Nat Rev Neurosci 14:128-142, 2013

APA	Ozdemir B, Kanat A, Kazdal H (2020). Deneysel Beyin Yaralanma Modelleri. , 308 - 311.
Chicago	Ozdemir Bulent,Kanat Ayhan,Kazdal Hizir Deneysel Beyin Yaralanma Modelleri. (2020): 308 - 311.
MLA	Ozdemir Bulent,Kanat Ayhan,Kazdal Hizir Deneysel Beyin Yaralanma Modelleri. , 2020, ss.308 - 311.
AMA	Ozdemir B,Kanat A,Kazdal H Deneysel Beyin Yaralanma Modelleri. . 2020; 308 - 311.
Vancouver	Ozdemir B,Kanat A,Kazdal H Deneysel Beyin Yaralanma Modelleri. . 2020; 308 - 311.
IEEE	Ozdemir B,Kanat A,Kazdal H "Deneysel Beyin Yaralanma Modelleri." , ss.308 - 311, 2020.
ISNAD	Ozdemir, Bulent vd. "Deneysel Beyin Yaralanma Modelleri". (2020), 308-311.

APA	Ozdemir B, Kanat A, Kazdal H (2020). Deneysel Beyin Yaralanma Modelleri. Türk Nöroşirürji Dergsi, 30(2), 308 - 311.
Chicago	Ozdemir Bulent,Kanat Ayhan,Kazdal Hizir Deneysel Beyin Yaralanma Modelleri. Türk Nöroşirürji Dergsi 30, no.2 (2020): 308 - 311.
MLA	Ozdemir Bulent,Kanat Ayhan,Kazdal Hizir Deneysel Beyin Yaralanma Modelleri. Türk Nöroşirürji Dergsi, vol.30, no.2, 2020, ss.308 - 311.
AMA	Ozdemir B,Kanat A,Kazdal H Deneysel Beyin Yaralanma Modelleri. Türk Nöroşirürji Dergsi. 2020; 30(2): 308 - 311.
Vancouver	Ozdemir B,Kanat A,Kazdal H Deneysel Beyin Yaralanma Modelleri. Türk Nöroşirürji Dergsi. 2020; 30(2): 308 - 311.
IEEE	Ozdemir B,Kanat A,Kazdal H "Deneysel Beyin Yaralanma Modelleri." Türk Nöroşirürji Dergsi, 30, ss.308 - 311, 2020.
ISNAD	Ozdemir, Bulent vd. "Deneysel Beyin Yaralanma Modelleri". Türk Nöroşirürji Dergsi 30/2 (2020), 308-311.