TY  - JOUR
TI  - Benfluorex, Friends or Foe? The Effects of Benfluorex on Oxidative Status in the Brain During Experimental Diabetes
AB  - Benfluorex is a pharmacological agent with antidiabetic and antihyperlipidemic properties. In this study, the brain's oxidative and non-enzymatic antioxidant status in diabetic and benfluorex administrated diabetic rats have been investigated. For the experimental procedures, three groups of 18 Wistar albino rats were used as the control, diabetes (induced by streptozotocin), and benfluorex treated diabetic rats (benfluorex administration intragastric 50 mg/kg daily for 21 days). Brain NOx, TBARS, GSH, AA levels, and MPO activity were determined spectrophotometrically. Benfluorex administration was caused that decreased lipid peroxidation and MPO activity while increased non-enzymatic antioxidant and NOx levels. These results showed that benfluorex treatment positively affects lipid peroxidation and non-enzymatic antioxidant status of the brain during diabetes.
AU  - COŞKUN CEVHER, ŞULE
AU  - GÜLEÇ PEKER, Emine Gülçeri
AU  - BALABANLI, BARBAROS
AU  - özer, çiğdem
DO  - 10.35229/jaes.929547
PY  - 2021
JO  - JOURNAL OF ANATOLIAN ENVIRONMENTAL AND ANIMAL SCIENCES
VL  - 6
IS  - 3
SN  - 2548-0006
SP  - 357
EP  - 363
DB  - TRDizin
UR  - http://search/yayin/detay/450535
ER  -