TY  - JOUR
TI  - Investigation of Aloe Vera Barbadensis Miller Leaf Extract Effects On Glutamate and Glyphosate Induced Toxicity: In Vitro Study
AB  - Aloe vera is one of the medicinal plants whose importance has been better understoodrecently with its antibacterial, antimicrobial, antioxidant and anticancer properties. Although it isknown that the aloe vera family has protective effects on neurons, the neuroprotective effect ofthe aloe barbadensis miller plant has not yet been fully explained. Glufosinate is structurallysimilar to glutamate and is an herbicide that blocks glutamine synthesis. Glutamate has beenshown to induce cyclooxygenase-2 (COX-2), which causes toxicity. In the present study, neuronculture was exposed to Aloe vera barbadensis Miller plant extracts plant (25, 50, 100, 200, 400,800, and 1600 µgr/ml doses) for 24 hours to protect against glufosinate (200 mM) and glutamate(10-5 mM) toxicity. After 24 hours, MTT, TAC, and TOS analyzes were performed and the resultswere revealed. In our study, it was seen that the aqueous extract of aloe barbadensis miller plant,glufosinate, and glutamate, could preserve the vitality of neurons (89% protection in AVB 400µgr/ml group). At the same time, it was seen that while increasing the antioxidant level in neurons,it decreased the oxidant level. The group that increases the antioxidant value best is AVB 400µgr/ml (the group that increases it 1.4 times). When the findings were evaluated, it was concludedthat aloe vera and its components may have a neuroprotective effect.
AU  - Türkmen, Aybike
AU  - TAGHİZADEHGHALEHJOUGHİ, Ali
AU  - Hacimuftuoglu, Ahmet
AU  - Yilmaz, Aysegul
DO  - 10.35229/jaes.953830
PY  - 2021
JO  - JOURNAL OF ANATOLIAN ENVIRONMENTAL AND ANIMAL SCIENCES
VL  - 6
IS  - 3
SN  - 2548-0006
SP  - 376
EP  - 381
DB  - TRDizin
UR  - http://search/yayin/detay/450557
ER  -