For the first time, people of this age experienced being isolated due to the Covid-19 Outbreak. This situation is considered as a different threshold for the process of alienation, which seems to take place in stages in the modern individual’s consciousness. Alienation defines new possibilities into which the individual is drawn, as the returns to modern life render traditional values dysfunctional. In this direction, it has been observed that pioneering artists have been under the influence of alienation as of modern times and have made productions that can be defined as a reflection of the social consciousness. The distinction of the world image seen in reality and reflected from the work of art informs the subconscious of the artist and therefore the society. In the transforming world and as a part of the society, the artist individual developed sensitivity in this direction and defined the works of art on the sociological axis as well as psychological one. The research aims to reveal the transformation of the concept of alienation as the main problem in the Covid-19 epidemic process and the reflections of the necessarily alienated individual on art production. The study examines the approaches of thinkers in the historical line towards the concept of alienation and examples from the productions of contemporary artists who were exposed to isolation during the Covid-19 epidemic.