Lead and Cadmium Induced Oxidative Stress in the Epididymis and Spleen of Rats: Effects of Sesamol

Fatma APAYDIN, (Gazi Üniversitesi, Fen Fakültesi, Biyoloji Bölümü, Ankara, Türkiye)
Hatice BAŞ, (Yozgat Bozok Üniversitesi, Fen-Edebiyat Fakültesi, Biyoloji Bölümü, Yozgat, Türkiye)
Yusuf KALENDER (Gazi Üniversitesi, Fen Fakültesi, Biyoloji Bölümü, Ankara, Türkiye)
Commagene Journal of Biology
4 0
Yıl: 2021 Cilt: 5 Sayı: 1 Sayfa Aralığı: 7 - 11 Metin Dili: İngilizce DOI: 10.31594/commagene.797945 İndeks Tarihi: 29-07-2022

Lead and Cadmium Induced Oxidative Stress in the Epididymis and Spleen of Rats: Effects of Sesamol

Öz:
Lead and cadmium are known as environmental pollutants extensively found in food and water that induce hazardsto animals’ and people’s health. Sesamol is a dietary antioxidant that is found in some plants. Epididymis is known to play animportant role in the maturation and storage of the sperm. The spleen is an important organ involved in the immune response.The present study aims to analyze the oxidative stress in spleen and epididymis. Therefore, Lead (LN) (90 mg/kg bw per day,1/25 LD50), Cadmium (CdCl2) (3 mg/kg bw per day, 1/25 LD50), and sesamol (50 mg/kg bw per day) were given to rats bygavage for 28 days. Antioxidant enzyme activities in epididymis and spleen tissues [superoxide dismutase (SOD), catalase(CAT), glutathione peroxidase (GPx) and glutathione S transferase], malondialdehyde (MDA) were investigated at the end of28 days comparatively with the control group. It is revealed that there is a significant decline in the antioxidant enzymes andincrease in MDA levels in the spleen and epididymis tissues of the lead and cadmium treated rats compared to the controlgroup. A small increase in these parameters was also observed in the sesamol treated groups.
Anahtar Kelime: organ toxicity Lipid peroxidation Antioxidants Heavy metals

Sıçanların Epididimis ve Dalak Dokularında Kurşun ve Kadmiyuma Bağlı Oksidatif Strese Karşı Sesamolün Etkileri

Öz:
Kurşun ve kadmiyum, hayvan ve insan sağlığına zarar veren gıda ve su kirleticilerinde yaygın olarak bulunan bilinen çevre kirleticileridir. Sesamol, bazı bitkilerde bulunan bir diyet antioksidanıdır. Epididimisin spermin olgunlaşması ve depolanmasında önemli bir rol oynadığı bilinmektedir. Dalak, bağışıklık tepkisinde rol oynayan önemli bir organdır. Bu çalışma, dalak ve epididimdeki oksidatif stresi analiz etmeyi amaçlamaktadır. Bu amaçla sıçanlara kurşun (günde 90 mg/kg canlı ağırlık, 1/25 LD50), kadmiyum (günde 3 mg/kg canlı ağırlık, 1/25 LD50) ve sesamol (günde 50 mg/kg canlı ağırlık) verildi. 28 gün boyunca gavaj, 28 gün sonunda epididimis ve dalak dokularındaki antioksidan enzim aktiviteleri [süperoksit dismutaz (SOD), katalaz (CAT), glutasyon peroksidaz (GPx) ve glutatyon S transferaz], malondialdehit (MDA) kontrol grubu ile karşılaştırmalı olarak araştırıldı. Kontrol grubuna göre kurşun ve kadmiyum uygulanan sıçanların dalak ve epididimis dokularında antioksidan enzimlerinde istatistiksel olarak anlamlı bir azalma ve MDA düzeylerinde artış olmuştur. Bu parametrelerde sesamol ile tedavi edilen gruplarda daha az artış gözlenmiştir
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA UZUN APAYDIN F, baş h, Kalender Y (2021). Lead and Cadmium Induced Oxidative Stress in the Epididymis and Spleen of Rats: Effects of Sesamol. , 7 - 11. 10.31594/commagene.797945
Chicago UZUN APAYDIN FATMA GÖKÇE,baş hatice,Kalender Yusuf Lead and Cadmium Induced Oxidative Stress in the Epididymis and Spleen of Rats: Effects of Sesamol. (2021): 7 - 11. 10.31594/commagene.797945
MLA UZUN APAYDIN FATMA GÖKÇE,baş hatice,Kalender Yusuf Lead and Cadmium Induced Oxidative Stress in the Epididymis and Spleen of Rats: Effects of Sesamol. , 2021, ss.7 - 11. 10.31594/commagene.797945
AMA UZUN APAYDIN F,baş h,Kalender Y Lead and Cadmium Induced Oxidative Stress in the Epididymis and Spleen of Rats: Effects of Sesamol. . 2021; 7 - 11. 10.31594/commagene.797945
Vancouver UZUN APAYDIN F,baş h,Kalender Y Lead and Cadmium Induced Oxidative Stress in the Epididymis and Spleen of Rats: Effects of Sesamol. . 2021; 7 - 11. 10.31594/commagene.797945
IEEE UZUN APAYDIN F,baş h,Kalender Y "Lead and Cadmium Induced Oxidative Stress in the Epididymis and Spleen of Rats: Effects of Sesamol." , ss.7 - 11, 2021. 10.31594/commagene.797945
ISNAD UZUN APAYDIN, FATMA GÖKÇE vd. "Lead and Cadmium Induced Oxidative Stress in the Epididymis and Spleen of Rats: Effects of Sesamol". (2021), 7-11. https://doi.org/10.31594/commagene.797945
APA UZUN APAYDIN F, baş h, Kalender Y (2021). Lead and Cadmium Induced Oxidative Stress in the Epididymis and Spleen of Rats: Effects of Sesamol. Commagene Journal of Biology, 5(1), 7 - 11. 10.31594/commagene.797945
Chicago UZUN APAYDIN FATMA GÖKÇE,baş hatice,Kalender Yusuf Lead and Cadmium Induced Oxidative Stress in the Epididymis and Spleen of Rats: Effects of Sesamol. Commagene Journal of Biology 5, no.1 (2021): 7 - 11. 10.31594/commagene.797945
MLA UZUN APAYDIN FATMA GÖKÇE,baş hatice,Kalender Yusuf Lead and Cadmium Induced Oxidative Stress in the Epididymis and Spleen of Rats: Effects of Sesamol. Commagene Journal of Biology, vol.5, no.1, 2021, ss.7 - 11. 10.31594/commagene.797945
AMA UZUN APAYDIN F,baş h,Kalender Y Lead and Cadmium Induced Oxidative Stress in the Epididymis and Spleen of Rats: Effects of Sesamol. Commagene Journal of Biology. 2021; 5(1): 7 - 11. 10.31594/commagene.797945
Vancouver UZUN APAYDIN F,baş h,Kalender Y Lead and Cadmium Induced Oxidative Stress in the Epididymis and Spleen of Rats: Effects of Sesamol. Commagene Journal of Biology. 2021; 5(1): 7 - 11. 10.31594/commagene.797945
IEEE UZUN APAYDIN F,baş h,Kalender Y "Lead and Cadmium Induced Oxidative Stress in the Epididymis and Spleen of Rats: Effects of Sesamol." Commagene Journal of Biology, 5, ss.7 - 11, 2021. 10.31594/commagene.797945
ISNAD UZUN APAYDIN, FATMA GÖKÇE vd. "Lead and Cadmium Induced Oxidative Stress in the Epididymis and Spleen of Rats: Effects of Sesamol". Commagene Journal of Biology 5/1 (2021), 7-11. https://doi.org/10.31594/commagene.797945
Sayfa Oluşturulma Tarihi
23-04-2024 19:39

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