TY  - JOUR
TI  - The Role of Citrus Nobiletin on Oxidative Stress Levels and Superoxide Dismutase Activities in Metastatic Castration-Resistant Prostate Cancer
AB  - Nobiletin (NOB) is a polymethoxylated flavone. It has multiple biologic activities that can modulate oxidative stressin many cancer types. However, there is no study in the literature that has examined the effects of NOB on oxidative stresslevels in Metastatic Castration-Resistant Prostate Cancer (MCRPC) yet. Motivated from this gap, we investigated the impactof NOB on oxidative stress and superoxide dismutase (SOD) enzyme activities in MCRPC as a preliminary study. For thispurpose, PC-3 and HUVEC cells were used to determine the effects of NOB on the amount of Malondialdehyde (MDA),hydrogen peroxide ($H_2O_2$), and proline as well as SOD enzyme activities. NOB potentially induced SOD enzyme activities butthe level of MDA, $H_2O_2$, and proline decreased after incubation with NOB in PC-3 cells (p<.05 and p<.001 were consideredstatistically significant). Our results confirmed that NOB acted as a protective agent for cancer cells and could selectivelyregulate oxidant status in MCRPC cells. Consequently, these preliminary findings provide better insight into the role of citrusNOB on oxidative stress levels and antioxidant enzyme activities in MCRPC. Additionally, there is a need to elucidate themolecular mechanisms of this cytoprotective effect of NOB as a potential chemotherapeutic agent.
AU  - Yuksel, Burcu
AU  - Deveci Özkan, Asuman
DO  - 10.31594/commagene.895415
PY  - 2021
JO  - Commagene Journal of Biology
VL  - 5
IS  - 1
SN  - 2602-456X
SP  - 84
EP  - 89
DB  - TRDizin
UR  - http://search/yayin/detay/451329
ER  -