Aim: The aim of this paper is to determine the relationship between intercultural relationship and the critical thinking disposition in nursing students. Method: This survey is a cross-sectional survey. The population of the survey consists of 540 students who were training in the academic year 2018-2019 at the department of nursing of the faculty of health sciences in a University in the West Turkey. No sample selection was made from the population. The survey was completed with 399 students who had been reached and accepted to partake in the study. The data of the survey were collected using determining questions, the Cultural Effectiveness Scale, and Critical thinking disposition Scale, which is used to determine sufficiency in intercultural communication, via face-to-face interview method between February and March 2019. Written consent from the ethical committee, institution and the participants were procured. The data were evaluated by the surveyors with descriptive statistics and correlation analyses in SPSS 25. Finding: It was deduced that the average points of the nursing students in critical thinking and intercultural effectiveness were 182.4±31.13 and 66.9±8.34. The points were accepted as point average in accordance with literature. A meaningful relationship between the total point averages of nursing students in intercultural effectiveness scale and critical thinking disposition scale was found (r=488, p<0.01). Conclusion: In accordance with these results, studies to develop students’ critical thinking disposition and sufficiency in intercultural communication.