The Importance of MPV as a Marker of Subclinical Inflammation inFMF Patients and It’s Correlation with Disease Severity
Yıl: 2021 Cilt: 48 Sayı: 3 Sayfa Aralığı: 387 - 395 Metin Dili: İngilizce DOI: 10.5798/dicletip.987759 İndeks Tarihi: 14-10-2021
The Importance of MPV as a Marker of Subclinical Inflammation inFMF Patients and It’s Correlation with Disease Severity
Öz: Objective: Inflammation markers increase during Familial Mediterranean Fever (FMF) attacks and often return to normal within a few days. It is known that a subclinical inflammation continues in FMF patients in the inter-episode period, which increases the risk of developing amyloidosis. In recent years, several works have been conducted showing the relationship between platelet indices and inflammation, such as platelet count (PLT), platelet distribution width (PDW), mean platelet volume (MPV), plateletrite (PCT). In this study, we aimed to investigate the relationship between platelet indices and disease severity in FMF patients without attacks. Method: The records of all FMF patients followed by us were reviewed retrospectively. Patients with a hematological or oncological disease, patients with data deficiency for the study, and patients under 18 years of age were excluded. While the laboratory data were recorded, the condition of patients to be at least 3 months without attack was required. As the control group, the automation records of all healthcare professionals working in the internal medicine clinic of our hospital were examined. Our clinical staff, who did not have chronic diseases and regular drug use, were taken as a healthy control group. 173 patients and 20 control groups who met the conditions mentioned above were included in the study. Platelet indices were compared between patient and control groups.Results: It was determined that the value of MPV, one of the platelet indices, in the patient group was statistically significantly higher than the value in the healthy control group (p = 0.029). MPV was also found to correlate with disease severity (p <0.001 r = 0.329).Discussion-Conclusion: In our study, it was determined that MPV was higher in FMF patients in the subclinical period compared to healthy controls and also correlated with disease severity. Studies investigating platelet indices and the risk of developing amyloidosis are needed in FMF patients.
Anahtar Kelime: MPV’nin FMF Hastalarında Subklinik İnflamasyon Belirteci Olarak Önemi ve Hastalık Şiddeti ile Korelasyonu
Öz: Giriş: Ailesel Akdeniz Ateşi (FMF) atakları anında inflamasyon belirteçleri artış göstermekte ve çoğu zaman birkaç gün içerisindenormale dönmektedir. Ataklar arası dönemde de FMF hastalarında subklinik bir inflamasyonun devam ettiği ve bunun da amiloidoz gelişme riskini artırdığı bilinmektedir. Son yıllarda, trombosit sayısı (PLT), trombosit dağılım genişliği (PDW), ortalama trombosithacmi (MPV), plateletkrit (PCT) gibi trombosit indeksleri ile inflamasyon arasındaki ilişkiyi gösteren birçok çalışma yapılmıştır. Buçalışmamızda ataksız dönemdeki FMF hastalarında trombosit indeksleri ile hastalık şiddeti arasındaki ilişkiyi araştırmayı amaçladık.Yöntemler: Kliniğimizce takip edilen tüm FMF hastalarının dosyaları retrospektif tarandı. Hematolojik veya onkolojik bir hastalığasahip olanlar, çalışma için veri eksikliği olan hastalar ve 18 yaşından küçük hastalar çalışmaya alınmadı. Laboratuvar verileri kayıtaltına alınırken hastaların en az 3 aylık ataksız dönemde olmaları koşulu arandı. Kontrol grubu olarak hastanemiz iç hastalıklarıkliniğinde çalışan tüm sağlık çalışanlarının otomasyon kayıtları incelendi. Kronik hastalık ve düzenli ilaç kullanımı olmayan klinikçalışanlarımız sağlıklı kontrol grubu olarak alındı. Yukarıda belirtilen koşulları sağlayan 173 hasta ve 20 kontrol grubu çalışmaya dahiledildi. Hasta ve kontrol grupları arasında trombosit indeksleri karşılaştırıldı. Bulgular: Trombosit indekslerinden MPV'nin hasta grubundaki değeri sağlıklı kontrol grubundaki değerine göre istatiksel olarakanlamlı derecede yüksek bulunduğu tespit edildi(p= 0,029). MPV’nin aynı zamanda hastalık şiddeti ile de korelasyon gösterdiği tespitedildi (p<0,001 r=0,329).Tartışma-Sonuç: Çalışmamızda MPV’nin subklinik dönemde FMF hastalarında sağlıklı kontrollere göre yüksek olduğu ve aynızamanda hastalık şiddeti ile de korelasyon gösterdiği saptanmıştır. FMF hastalarında trombosit indeksleri ve amiloidoz gelişim riskiniaraştıran çalışmalara ihtiyaç vardır.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Diğer Erişim Türü: Erişime Açık
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| APA | Çeliker M, kazan s, Tunca O, sari a, KÖROĞLU M, ULU M (2021). The Importance of MPV as a Marker of Subclinical Inflammation inFMF Patients and It’s Correlation with Disease Severity. , 387 - 395. 10.5798/dicletip.987759 |
| Chicago | Çeliker Mesut,kazan sinan,Tunca Onur,sari alper,KÖROĞLU MUSTAFA,ULU MEMNUNE SENA The Importance of MPV as a Marker of Subclinical Inflammation inFMF Patients and It’s Correlation with Disease Severity. (2021): 387 - 395. 10.5798/dicletip.987759 |
| MLA | Çeliker Mesut,kazan sinan,Tunca Onur,sari alper,KÖROĞLU MUSTAFA,ULU MEMNUNE SENA The Importance of MPV as a Marker of Subclinical Inflammation inFMF Patients and It’s Correlation with Disease Severity. , 2021, ss.387 - 395. 10.5798/dicletip.987759 |
| AMA | Çeliker M,kazan s,Tunca O,sari a,KÖROĞLU M,ULU M The Importance of MPV as a Marker of Subclinical Inflammation inFMF Patients and It’s Correlation with Disease Severity. . 2021; 387 - 395. 10.5798/dicletip.987759 |
| Vancouver | Çeliker M,kazan s,Tunca O,sari a,KÖROĞLU M,ULU M The Importance of MPV as a Marker of Subclinical Inflammation inFMF Patients and It’s Correlation with Disease Severity. . 2021; 387 - 395. 10.5798/dicletip.987759 |
| IEEE | Çeliker M,kazan s,Tunca O,sari a,KÖROĞLU M,ULU M "The Importance of MPV as a Marker of Subclinical Inflammation inFMF Patients and It’s Correlation with Disease Severity." , ss.387 - 395, 2021. 10.5798/dicletip.987759 |
| ISNAD | Çeliker, Mesut vd. "The Importance of MPV as a Marker of Subclinical Inflammation inFMF Patients and It’s Correlation with Disease Severity". (2021), 387-395. https://doi.org/10.5798/dicletip.987759 |
| APA | Çeliker M, kazan s, Tunca O, sari a, KÖROĞLU M, ULU M (2021). The Importance of MPV as a Marker of Subclinical Inflammation inFMF Patients and It’s Correlation with Disease Severity. Dicle Tıp Dergisi, 48(3), 387 - 395. 10.5798/dicletip.987759 |
| Chicago | Çeliker Mesut,kazan sinan,Tunca Onur,sari alper,KÖROĞLU MUSTAFA,ULU MEMNUNE SENA The Importance of MPV as a Marker of Subclinical Inflammation inFMF Patients and It’s Correlation with Disease Severity. Dicle Tıp Dergisi 48, no.3 (2021): 387 - 395. 10.5798/dicletip.987759 |
| MLA | Çeliker Mesut,kazan sinan,Tunca Onur,sari alper,KÖROĞLU MUSTAFA,ULU MEMNUNE SENA The Importance of MPV as a Marker of Subclinical Inflammation inFMF Patients and It’s Correlation with Disease Severity. Dicle Tıp Dergisi, vol.48, no.3, 2021, ss.387 - 395. 10.5798/dicletip.987759 |
| AMA | Çeliker M,kazan s,Tunca O,sari a,KÖROĞLU M,ULU M The Importance of MPV as a Marker of Subclinical Inflammation inFMF Patients and It’s Correlation with Disease Severity. Dicle Tıp Dergisi. 2021; 48(3): 387 - 395. 10.5798/dicletip.987759 |
| Vancouver | Çeliker M,kazan s,Tunca O,sari a,KÖROĞLU M,ULU M The Importance of MPV as a Marker of Subclinical Inflammation inFMF Patients and It’s Correlation with Disease Severity. Dicle Tıp Dergisi. 2021; 48(3): 387 - 395. 10.5798/dicletip.987759 |
| IEEE | Çeliker M,kazan s,Tunca O,sari a,KÖROĞLU M,ULU M "The Importance of MPV as a Marker of Subclinical Inflammation inFMF Patients and It’s Correlation with Disease Severity." Dicle Tıp Dergisi, 48, ss.387 - 395, 2021. 10.5798/dicletip.987759 |
| ISNAD | Çeliker, Mesut vd. "The Importance of MPV as a Marker of Subclinical Inflammation inFMF Patients and It’s Correlation with Disease Severity". Dicle Tıp Dergisi 48/3 (2021), 387-395. https://doi.org/10.5798/dicletip.987759 |
