Reconstruction of an Isolated Unilateral Aplasia of Right Alar Cartilage

Congenital nasal anomalies regarding lower third of thenose including alar cartilages and columella are very rare. Hypoplasiaor aplasia of medial and lateral crural cartilages as well as columellamay be seen. These defects may result in varying degrees of functionaland cosmetic problems. In this study, we reported a septorhinoplastycase in which we encountered an isolated congenital aplasia of the rightalar cartilage. We presented our reconstruction technique and reviewedrelative literature data. In this study, we aimed to increase the awarenessof clinicians about this extremely rare clinical condition and to give anidea for possible reconstruction techniques.

Anahtar Kelime:

Comparison of Therapeutic Plasma Exchange and Double FiltrationPlasmapheresis: Five Year Experience of Nephrology Unit

Öz:

Objective: The aim of the study was to evaluate the outcomes and characteristics of therapeutic plasma exchange (TPE) and double filtration plasmapheresis (DFPP) in one center. Method: The data of cases treated with therapeutic plasmapheresis at the university hospital between 2007 and 2012 were retrospectively analyzed. 445 TPE and 391 DFPP sessions were done totally. Results: In the 5.5 years, in 116 cases 445 TPE and 391 DFPP sessions were done. The mean age was 46.61±16.83 years. There were 49 female and 67 male patients. Guillain-Barre syndrome ( 8.6%) was the commonly encountered indication for neurological diseases, glomerulonephritis ( 25%) was the leading indication for the renal-related diseases. Skin involvement due to diabetes mellitus (13.8%) and Pemphigus Vulgaris (5.2%) were the dermatological diseases. Complication rates were similar between DFPP and TPE sessions (p= 0.411). Conclusion: TPE and DFPP are safe and vital membrane separation techniques used as a treatment for a wide spectrum of diseases. These treatments can be safely done in hemodialysis units intensive care units and DFPP should be considered for the therapy refractory neurological diseases.

Anahtar Kelime:

Terapötik Plazmaferez ve Çift Filtreli Plazmaferez Tedavisinin Karşılaştırılması- Beş Yıllık Nefroloji Merkez Deneyimi

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Giriş: Bu çalışmanın amacı, tek merkezde yapılan terapötik plazma değişimi ve çift filtreli plazmaferez tedavisininsonuçlarının ve özelliklerinin değerlendirilmesidir. Yöntemler: 2007-2012 yılları arasında üniversite hastanesinde terapötik plazmaferez ile tedavi edilen olguların verilerigeriye dönük olarak incelendi. 445 TPE ve 391 DFPP seansı yapıldı Bulgular: 5.5 yılda 116 vakada 445 seans TPE ve 391 seans DFPP yapıldı. Ortalama yaş 46.61±16.83yıldı. 49 kadın ve 67erkek hasta vardı. Guillain-Barre sendromu (%8.6) nörolojik hastalıkların en sık rastlanan nedeni iken, böbrekle ilgilihastalıklarda en sık neden glomerülonefritlerdi (%26.1). Dermatolojik hastalıkların nedenleri Diyabetes Mellitus(%13.8) ve Pemfigus Vulgarisdi (%5,2). DFPP ve TPE komplikasyon oranları arasında fark yoktu (p= 0.411). Sonuç: TPE ve DFPP, çok çeşitli hastalıkların tedavisi olarak kullanılan güvenli ve hayati önemi olan tedavi yöntemleridir.Bu tedaviler hemodiyaliz üniteleri yoğun bakım ünitelerinde güvenle yapılabilir ve tedaviye dirençli nörolojikhastalıklarda ilk seçenek olarak DFPP kullanılabilinir.

Anahtar Kelime:

İzole Tek Taraflı Sağ Alar Kartilaj Aplazisinin Rekonstrüksiyonu

Öz:

Alar kartilajlar ve kolumellayı içeren burnun, alt 1/3 kısmının konjenital anomalileri oldukça nadirdir. Alar kartilaj mediyal ve lateral krusları ile kolumellada hipoplazi ve aplazi gibi anomaliler görülebilmektedir. Bu gibi defektler, değişen derecelerde kozmetik ve fonksiyonel sorunlara yol açabilir. Bu çalışmada bir septorinoplasti vakasında karşılaşılan izole sağ alar kartilaj aplazisi ve rekonstrüksiyonu literatür bilgileri eşliğinde sunulmuştur. Bu çalışmada bu nadir görülen klinik durum karşısında farkındalığı artırmak ve rekonstrüksiyon teknikleri hakkında bir fikir vermeyi amaçladık.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Olgu Sunumu Erişim Türü: Erişime Açık

1. Stegmayr B, Ramlow W, Balogun RA . Beyond Dialysis: Current and Emerging Blood Purification Techniques. Semin. Dial. 2012; 25: 207–13.
1. Losee JE, Kirschner RE, Whitaker LA, Bartlett SP. Congenital nasal anomalies: a classification scheme. Plast Reconstr Surg. 2004;113(2):676-89.
2. Williams M E, Balogun RA. Principles of separation: Indications and therapeutic targets for plasma exchange. Clinical Journal of the American Society of Nephrology 2014; 9: 181–90.
2. Kosins AM, Daniel RK, Sajjadian A, Helms J. Rhinoplasty: congenital deficiencies of the alar cartilage. Aesthet Surg J. 2013;33(6):799-808.
3. Padmanabhan A, Connely- Smith L, Aquio N, et al. Guidelines on the Use of Therapeutic Apheresis in Clinical Practice - Evidence-Based Approach from the Writing Committee of the American Society for Apheresis: The Eighth Special Issue. J. Clin. Apher. 2019; 34: 171–354.
3. Adelson RT, Karimi K, Herrero N. Isolated congenital absence of the left lower lateral cartilage. Otolaryngol Head Neck Surg. 2008;138(6):793-4.
4. Malchesky PS, Koo AP, Roberson GA, et al. Apheresis technologies and clinical applications: The 2005 International Apheresis Registry. Ther. Apher. Dial. 2007; 11: 341–62.
4. Jacobs KF. Angeborene Aplasie von Nasensteg und knorpeligem Septum. Beschreibung eines Falles und der operativen Korrektur [Congenital aplasia of the nasal columella and cartilaginous septum]. Laryngol Rhinol Otol (Stuttg). 1984;63(7):344-6.
5. Alkhatib Y, Dadla A, Melik D., et al. Plasmapheresis and Myeloma Cast Nephropathy: A Meta-Analysis and Review of Evidence. Blood 2017; 130: 5415.
5. Coban YK, Dogan A, Erbatur S. Isolated congenital hypoplasia of nasal lower lateral cartilages and its correction with helical rim and conchal cartilage composite grafts. Cleft Palate Craniofac J. 2012;49(4):e42-5.
6. Li Q Y, Yu F, Zhou FD, et al. Plasmapheresis is associated with better renal outcomes in lupus nephritis patients with thrombotic microangiopathy a case series study. Med. 2016; 95: e3595.
6. Fijałkowska M, Antoszewski B. Nose underdevelopment - etiology, diagnosis and treatment. Otolaryngol Pol. 2016;70(2):13-8.
7. Filler G, Clark WF, Huang SHS. Tandem hemodialysis and plasma exchange. Pediatr. Nephrol. 2014; 29: 2077–82.
7. Barutca SA, Öreroğlu AR, Usçetin I, Kutlu N. Isolated congenital partial absence of the left lower lateral nasal cartilage: case report. Ann Plast Surg. 2011;67(6):662-4.
8. Şeker YT, Hergünsel OG, Bilgi, DÖ. Therapeutic plasmapheresis: an eleven-year clinical experience. Eur. Res. J. 2018; 4: 343–48.
8. Temiz G, Yeşiloğlu N, Sarici M, Filinte GT. Congenital isolated aplasia of lower lateral cartilage and reconstruction using dorsal hump material. J Craniofac Surg. 2014;25(5):e411-3.
9. Yilmaz AA, Can OS, Oral M, et al. Therapeutic plasma exchange in an intensive care unit (ICU): A 10-year, single-center experience. Transfus. Apher. Sci. 2011; 45: 161–6.
10. Stegmayr B, Tärnvik A. Complement activation in plasma exchange by single filtration and centrifugation and in cascade filtration. Blood Purif. 1989; 7: 10–15.
11. Lyu RK, Chen W H, Hsieh S T. Plasma exchange versus double filtration plasmapheresis in the treatment of Guillain-Barré syndrome. Ther. Apher. 2002; 6: 163–6.
12. Hirano R, Namazuda K, Hirata N. Double filtration plasmapheresis: Review of current clinical applications. Therapeutic Apheresis and Dialysis.2021; 25: 145–51.
13. Maxted AP, Connell R, Hussain F. Double filtration plasmapheresis – 10-year pediatric experience as an alternative to plasma exchange. Transfus. Apher. Sci.2020; 59: 1029-8.
14. Clark WF. Plasma exchange for renal disease: Evidence and use 2011. in Journal of Clinical Apheresis 2012; 27: 112–6.
15. Walsh M , Catapano F, Szpirt W, et al. Plasma exchange for renal vasculitis and idiopathic rapidly progressive glomerulonephritis: A meta-analysis. Am. J. Kidney Dis.2011; 57: 566–74.

APA	düzlü m, BERK S, cebeci s, BAKIRDÖĞEN S, sahin m, EREN N, KARAMERT R, HAZANAY Y, GÖNÜLLÜ B (2021). Reconstruction of an Isolated Unilateral Aplasia of Right Alar Cartilage. , 145 - 147. 10.24179/kbbbbc.2020-80117
Chicago	düzlü mehmet,BERK Sibel GÖKÇAY,cebeci süleyman,BAKIRDÖĞEN Serkan,sahin melih,EREN Necmi,KARAMERT RECEP,HAZANAY Yusuf,GÖNÜLLÜ Betül KALENDER Reconstruction of an Isolated Unilateral Aplasia of Right Alar Cartilage. (2021): 145 - 147. 10.24179/kbbbbc.2020-80117
MLA	düzlü mehmet,BERK Sibel GÖKÇAY,cebeci süleyman,BAKIRDÖĞEN Serkan,sahin melih,EREN Necmi,KARAMERT RECEP,HAZANAY Yusuf,GÖNÜLLÜ Betül KALENDER Reconstruction of an Isolated Unilateral Aplasia of Right Alar Cartilage. , 2021, ss.145 - 147. 10.24179/kbbbbc.2020-80117
AMA	düzlü m,BERK S,cebeci s,BAKIRDÖĞEN S,sahin m,EREN N,KARAMERT R,HAZANAY Y,GÖNÜLLÜ B Reconstruction of an Isolated Unilateral Aplasia of Right Alar Cartilage. . 2021; 145 - 147. 10.24179/kbbbbc.2020-80117
Vancouver	düzlü m,BERK S,cebeci s,BAKIRDÖĞEN S,sahin m,EREN N,KARAMERT R,HAZANAY Y,GÖNÜLLÜ B Reconstruction of an Isolated Unilateral Aplasia of Right Alar Cartilage. . 2021; 145 - 147. 10.24179/kbbbbc.2020-80117
IEEE	düzlü m,BERK S,cebeci s,BAKIRDÖĞEN S,sahin m,EREN N,KARAMERT R,HAZANAY Y,GÖNÜLLÜ B "Reconstruction of an Isolated Unilateral Aplasia of Right Alar Cartilage." , ss.145 - 147, 2021. 10.24179/kbbbbc.2020-80117
ISNAD	düzlü, mehmet vd. "Reconstruction of an Isolated Unilateral Aplasia of Right Alar Cartilage". (2021), 145-147. https://doi.org/10.24179/kbbbbc.2020-80117

APA	düzlü m, BERK S, cebeci s, BAKIRDÖĞEN S, sahin m, EREN N, KARAMERT R, HAZANAY Y, GÖNÜLLÜ B (2021). Reconstruction of an Isolated Unilateral Aplasia of Right Alar Cartilage. Kulak Burun Boğaz ve Baş Boyun Cerrahisi, 48(3), 145 - 147. 10.24179/kbbbbc.2020-80117
Chicago	düzlü mehmet,BERK Sibel GÖKÇAY,cebeci süleyman,BAKIRDÖĞEN Serkan,sahin melih,EREN Necmi,KARAMERT RECEP,HAZANAY Yusuf,GÖNÜLLÜ Betül KALENDER Reconstruction of an Isolated Unilateral Aplasia of Right Alar Cartilage. Kulak Burun Boğaz ve Baş Boyun Cerrahisi 48, no.3 (2021): 145 - 147. 10.24179/kbbbbc.2020-80117
MLA	düzlü mehmet,BERK Sibel GÖKÇAY,cebeci süleyman,BAKIRDÖĞEN Serkan,sahin melih,EREN Necmi,KARAMERT RECEP,HAZANAY Yusuf,GÖNÜLLÜ Betül KALENDER Reconstruction of an Isolated Unilateral Aplasia of Right Alar Cartilage. Kulak Burun Boğaz ve Baş Boyun Cerrahisi, vol.48, no.3, 2021, ss.145 - 147. 10.24179/kbbbbc.2020-80117
AMA	düzlü m,BERK S,cebeci s,BAKIRDÖĞEN S,sahin m,EREN N,KARAMERT R,HAZANAY Y,GÖNÜLLÜ B Reconstruction of an Isolated Unilateral Aplasia of Right Alar Cartilage. Kulak Burun Boğaz ve Baş Boyun Cerrahisi. 2021; 48(3): 145 - 147. 10.24179/kbbbbc.2020-80117
Vancouver	düzlü m,BERK S,cebeci s,BAKIRDÖĞEN S,sahin m,EREN N,KARAMERT R,HAZANAY Y,GÖNÜLLÜ B Reconstruction of an Isolated Unilateral Aplasia of Right Alar Cartilage. Kulak Burun Boğaz ve Baş Boyun Cerrahisi. 2021; 48(3): 145 - 147. 10.24179/kbbbbc.2020-80117
IEEE	düzlü m,BERK S,cebeci s,BAKIRDÖĞEN S,sahin m,EREN N,KARAMERT R,HAZANAY Y,GÖNÜLLÜ B "Reconstruction of an Isolated Unilateral Aplasia of Right Alar Cartilage." Kulak Burun Boğaz ve Baş Boyun Cerrahisi, 48, ss.145 - 147, 2021. 10.24179/kbbbbc.2020-80117
ISNAD	düzlü, mehmet vd. "Reconstruction of an Isolated Unilateral Aplasia of Right Alar Cartilage". Kulak Burun Boğaz ve Baş Boyun Cerrahisi 48/3 (2021), 145-147. https://doi.org/10.24179/kbbbbc.2020-80117