Yıl: 2021 Cilt: 56 Sayı: 5 Sayfa Aralığı: 463 - 468 Metin Dili: İngilizce DOI: 10.5152/TurkArchPediatr.2021.21076 İndeks Tarihi: 19-10-2021

Evaluation of Hematological Parameters of Children Diagnosed withCOVID-19: Single-Center Experience

Öz:
Objective: Although many pediatric studies on children infected with coronavirus disease 2019 (COVID-19) have been published, the diagnosis, clinical symptoms, laboratory findings, and treatment of COVID-19 in children are still unclear.Materials and Methods: This study was conducted with an aim to examine the hematological findings of symptomatic pediatric patients diagnosed with COVID-19 in May 2020 at the Pandemic Hospital in Dicle University. Patient records were evaluated retrospectively. This study involved 59 symptomatic pediatric patients with a definite diagnosis of COVID-19 who had positive SARS-CoV-2 RT-PCR test results on nasopharyngeal swab between March 15, 2020 and May 31, 2020. Results: The records of a total of 10 (16.9%) patients under the age of 1; 21 (35.6%) patients aged 1-10 years, and, 28 (47.5%) patients aged 10-18 years, who had been diagnosed with COVID-19 were evaluated. Based on severity, 35 (59.3%) patients were in the mild group (group 1) and 24 (40.7%) patients were in the moderate-severe group (group 2). The blood parameters of WBC, neutrophil, lymphocyte, monocyte, and thrombocyte counts, the hemoglobin (Hgb) level, and NLR, PLR, MPV, fibrinogen, ferritin, and D-dimer levels were compared between groups, the difference was not statistically significant (P > .05). LDH was higher in group 2 (P = .014).Conclusion: Since children infected with COVID-19 show mild clinical symptoms or are asymptomatic, fewer pediatric patients may be detected than adults. Therefore, it should be known that the laboratory findings typical for adults may not accompany the disease in pediatric cases. More studies are needed to determine the most appropriate COVID-19 treatment approach for children, as hospitalization history and testing rates are less reported among children.
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  • 1. World Health Organization (WHO).World Health Organization characterizes COVID-19 as a pandemic. 2020 (Available at: https ://www.who.int/emergencies/diseases/ novel-coronavirus-2019/ events-as-they-happen), Accessed July 31, 2020.
  • 2. Shereen MA, Khan S, Kazmi A, Bashir N, Siddique R. COVID-19 infection: origin, trans-mission, and characteristics of human coronaviruses. J Adv Res. 2020;24:91-98. [CrossRef]
  • 3. Kannan S, Shaik Syed Ali P, Sheeza A, Hemalatha K. COVID-19 (novel coronavirus 2019) recent trends. Eur Rev Med Pharmacol Sci. 2020;24(4):2006-2011. [CrossRef]
  • 4. Huang C, Wang Y, Li X, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395(10223):497-506. [CrossRef]
  • 5. Choi SH, Kim HW, Kang JM, Kim DH, Cho EY. Epidemiology and clinical features of coronavirus disease 2019 in children. Clin Exp Pediatr. 2020;63(4):125-132. [CrossRef]
  • 6. Johns Hopkins University Center for Systems Science and Engineering. Coronavirus COVID-19 global cases. 2020. (Available at: https://gisanddata maps.arcgis.com/apps/opsdashboard/index. html#/bda7594740fd40299423467b48e9ecf6), Accessed April 15, 2020.
  • 7. Lee PI, Hu YL, Chen PY, Huang YC, Hsueh PR. Are children less susceptible to COVID19. J Microbiol Immunol Infect. 2020;53(3):371- 372. [CrossRef]
  • 8. Shekerdemian LS, Mahmood NR, Wolfe KK, et al. Characteristics and outcomes of children with coronavirus Disease 2019 (COVID-19) infection admitted to US and Canadian pediatric intensive care units. JAMA Pediatr. 2020;174(9):868-873. [CrossRef]
  • 9. Türkiye Cumhuriyeti Sağlık Bakanlığı. Türkiye'deki COVID-19 durum Raporları. 2020. (Available at: http://covid19.saglik.gov.tr/Eklent i/37743/0/covid-19-situation-reportv4pdf.pdf) ), Accessed June 30, 2020.
  • 10. Castagnoli R, Votto M, Licari A, et al. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in children and adolescents: a systematic review. JAMA Pediatr. 2020;174(9):882-889. [CrossRef]
  • 11. Shen K, Yang Y, Wang T, et al. Diagnosis, treatment, and prevention of 2019 novel coronavirus infection in children: experts’ consensus statement. World J Pediatr. 2020;16(3):223-231. [CrossRef]
  • 12. Geaghan SM. Hematologic values and appearances in the healthy fetus, neonate, and child. Clin Lab Med. 1999;19(1):1-37. [CrossRef]
  • 13. Dallman PR. In: Rudolph A, ed. Pediatrics. 16th ed. New York: Appleton-Century-Crofts; 1977:1111-1178.
  • 14. Li W, Moore MJ, Vasilieva N, et al. Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus. Nature. 2003;426(6965):450-454. [CrossRef]
  • 15. Bi Q, Wu Y, Mei S, et al. Epidemiology and transmission of COVID19 in Shenzhen China: analysis of 391 cases and 1,286 of their close contacts. Lancet Infect Dis. 2020;20(8):911-919. [CrossRef]
  • 16. Fang F, Luo XP. Facing the pandemic of 2019 novel coronavirus infections: the pediatric perspectives. Zhonghua Er Ke Za Zhi. 2020;58(2):81-85. [CrossRef]
  • 17. Chen ZM, Fu JF, Shu Q, et al. Diagnosis and treatment recommendations for pediatric respiratory infection caused by the 2019 novel coronavirus. World J Pediatr. 2020;16(3):240-246. [CrossRef]
  • 18. Wang XF, Yuan J, Zheng YJ, et al. Retracted: clinical and epidemiological characteristics of 34 children with 2019 novel coronavirus infection in Shenzhen. Zhonghua Er Ke Za Zhi. 2020;58:E008. [CrossRef]
  • 19. Parri N, Lenge M, Buonsenso D, Coronavirus Infection in Pediatric Emergency Departments (CONFIDENCE) Research Group. Children with Covid-19 in pediatric emergency departments in Italy. N Engl J Med. 2020;383(2):187-190. [CrossRef]
  • 20. Lu X, Zhang L, Du H, et al. SARS-CoV-2 infection in children. N Engl J Med. 2020;382(17):1663-1665. [CrossRef]
  • 21. Dong Y, Mo X, Hu Y, et al. Epidemiology of COVID-19 among children in China. Pediatrics. 2020;145(6). [CrossRef]
  • 22. Centers for Disease Control and Prevention (U.S.). Coronavirus disease 2019 in children - United States, February 12-April 2, 2020. MMWR Morb Mortal Wkly Rep. 2020;69(14):422-426. [CrossRef] 23. Fan BE, Chong VCL, Chan SSW, et al. Hematologic parameters in patients with COVID-19 infection. Am J Hematol. 2020;95(6):E131- E134. [CrossRef]
  • 24. Henry BM, de Oliveira MHS, Benoit S, Plebani M, Lippi G. Hematologic, biochemical and immune biomarker abnormalities associated with severe illness and mortality in coronavirus disease 2019 (COVID-19): a meta-analysis. Clin Chem Lab Med. 2020;58(7):1021- 1028. [CrossRef]
  • 25. Lippi G, Plebani M, Henry BM. Thrombocytopenia is associated with severe coronavirus disease in 2019 (COVID-19) infections: a meta-analysis. Clin Chim Acta. 2020;506:145-148. [CrossRef]
  • 26. Guan WJ, Ni ZY, Hu Y, et al. Clinical characteristics of coronavirus disease 2019 in China. N Engl J Med. 2020;382(18):1708-1720. [CrossRef]
  • 27. Wang F, Nie J, Wang H, et al. Characteristics of peripheral lymphocyte subset alteration in COVID-19 pneumonia. J Infect Dis. 2020;221(11):1762-1769. [CrossRef]
  • 28. Li YX, Wu W, Yang T, et al. Characteristics of peripheral blood leukocyte differential count in patients with COVID-19. Zhonghua Nei Ke Za Zhi. 2020;59:E003-E003.
  • 29. Ludvigsson JF. Systematic review of COVID-19 in children shows milder cases and a better prognosis than adults. Acta Paediatr. 2020;109(6):1088-1095. [CrossRef]
  • 30. Zimmermann P, Curtis N. Coronavirus infections in children including COVID-19: an overview of the epidemiology, clinical features, diagnosis, treatment, and prevention. Pediatr Infect Dis J. 2020;39(5):355-368. [CrossRef]
  • 31. Xia W, Shao J, Guo Y, et al. Clinical and CT feature in pediatric patients with COVID‐19 infection: different points from adults. Pediatr Pulmonol. 2020;55(5):1169- 1174. [CrossRef]
  • 32. Liu J, Liu Y, Xiang P, et al. Neutrophil to lymphocyte ratio predicts severe illness patients with 2019 novel coronavirus in the early stage. MedRxiv 2020;39. [CrossRef]
  • 33. Cao Q, Chen YC, Chen CL, Chiu CH. SARS-CoV-2 infection in children: transmission dynamics and clinical characteristics. J Formos Med Assoc. 2020;119(3):670-673. [CrossRef]
  • 34. Henry BM, Lippi G, Plebani M. Laboratory abnormalities in children with novel coronavirus disease 2019. Clin Chem Lab Med. 2020;58(7):1135-1138. [CrossRef]
  • 35. Lippi G, Plebani M. The critical role of laboratory medicine during coronavirus disease 2019 (COVID-19) and other viral outbreaks. Clin Chem Lab Med. 2020;58(7):1063-1069. [CrossRef]
  • 36. Mehta P, McAuley DF, Brown M, et al. HLH across speciality collaboration, UK. COVID19: consider cytokine storm syndromes and immunosuppression. Lancet. 2020;395(10229):1033-1034. [CrossRef]
  • 37. Walkovich KL, Newburger PE. Leukopenia. In: Kliegman RM, Stanton BF, St Geme JW III, Schor NF, Behrman RE, eds. Nelson Textbook of Pediatrics. 20th ed., International ed. Elsevier; 2016:1047-1055.
  • 38. Zhang B, Zhou X, Zhu C, et al. Immune phenotyping based on the neutrophil-to-lymphocyte ratio and IgG level predicts disease severity and outcome for patients with COVID-19. Front Mol Biosci. 2020;7:157. [CrossRef]
  • 39. Channappanavar R, Perlman S. Pathogenic human coronavirus infections: causes and consequences of cytokine storm and immunopathology. Semin Immunopathol. 2017;39(5):529- 539. [CrossRef]
  • 40. Liu Y, Xiang P, Pu L, et al. Neutrophil-to-lymphocyte ratio predicts severe illness patients with 2019 novel coronavirus in the early stage. MedRxiv. 2020. [CrossRef]
  • 41. Perlman S. Another decade, another coronavirus. N Engl J Med. 2020;382(8):760-762. [CrossRef]
  • 42. Elsayed AM, Mohamed GA. Mean platelet volume and mean platelet volume/platelet count ratio as a risk stratification tool in the assessment of the severity of acute ischemic stroke. Alex J Med. 2017;53(1):67-70. [CrossRef]
  • 43. Taneri PE, Gomez-Ochoa SA, Llanaj E, et al. Anemia and iron metabolism in COVID-19: a systematic review and meta-analysis. MedRxiv. 2020;385. [CrossRef]
  • 44. Centers for Disease Control and Prevention (U.S). Multisystem inflammatory syndrome in children (MIS-C) associated with coronavirus disease 2019 (COVID-19), clinician outreach and communication (COCA) webinar. (Available at: https://emergency.cd c.gov/coca/calls/2020/callinfo_051920.asp?deliveryName= USCDC_1052-DM28623) Accessed May 19.
  • 45. Başar EZ, Sönmez HE, Öncel S, Yetimakman AF, Babaoğlu K. Multisystemic inflammatory syndrome in children associated with COVID-19: a single-center experience in Turkey. Turk Arch Pediatr. 2021;56(3):192-199. [CrossRef]
  • 46. Lott JA, Nemensanszky E. Lactate dehydrogenase. In: Lott JA, Wolf PL, eds. Clinical Enzymology, Case-Oriented Approach. New York: Year Book Medical Publisher; 1987:213-244.
  • 47. Moss DW, Henderson AR. Enzymes. In: Burtis CA, Ashwood ER, eds. Tietz Textbook of Clinical Chemistry. 2nd ed. Philadelphia: Saunders Company; 1986:735-896.
APA üzel v, Yılmaz K, ŞEN v, aktar f, karabel m, yolbaş i, gözü pirinççioğlu a, SOKER M (2021). Evaluation of Hematological Parameters of Children Diagnosed withCOVID-19: Single-Center Experience. , 463 - 468. 10.5152/TurkArchPediatr.2021.21076
Chicago üzel veysiye hülya,Yılmaz Kamil,ŞEN velat,aktar fesih,karabel müsemma,yolbaş ilyas,gözü pirinççioğlu ayfer,SOKER MURAT Evaluation of Hematological Parameters of Children Diagnosed withCOVID-19: Single-Center Experience. (2021): 463 - 468. 10.5152/TurkArchPediatr.2021.21076
MLA üzel veysiye hülya,Yılmaz Kamil,ŞEN velat,aktar fesih,karabel müsemma,yolbaş ilyas,gözü pirinççioğlu ayfer,SOKER MURAT Evaluation of Hematological Parameters of Children Diagnosed withCOVID-19: Single-Center Experience. , 2021, ss.463 - 468. 10.5152/TurkArchPediatr.2021.21076
AMA üzel v,Yılmaz K,ŞEN v,aktar f,karabel m,yolbaş i,gözü pirinççioğlu a,SOKER M Evaluation of Hematological Parameters of Children Diagnosed withCOVID-19: Single-Center Experience. . 2021; 463 - 468. 10.5152/TurkArchPediatr.2021.21076
Vancouver üzel v,Yılmaz K,ŞEN v,aktar f,karabel m,yolbaş i,gözü pirinççioğlu a,SOKER M Evaluation of Hematological Parameters of Children Diagnosed withCOVID-19: Single-Center Experience. . 2021; 463 - 468. 10.5152/TurkArchPediatr.2021.21076
IEEE üzel v,Yılmaz K,ŞEN v,aktar f,karabel m,yolbaş i,gözü pirinççioğlu a,SOKER M "Evaluation of Hematological Parameters of Children Diagnosed withCOVID-19: Single-Center Experience." , ss.463 - 468, 2021. 10.5152/TurkArchPediatr.2021.21076
ISNAD üzel, veysiye hülya vd. "Evaluation of Hematological Parameters of Children Diagnosed withCOVID-19: Single-Center Experience". (2021), 463-468. https://doi.org/10.5152/TurkArchPediatr.2021.21076
APA üzel v, Yılmaz K, ŞEN v, aktar f, karabel m, yolbaş i, gözü pirinççioğlu a, SOKER M (2021). Evaluation of Hematological Parameters of Children Diagnosed withCOVID-19: Single-Center Experience. Turkish archives of pediatrics (Online), 56(5), 463 - 468. 10.5152/TurkArchPediatr.2021.21076
Chicago üzel veysiye hülya,Yılmaz Kamil,ŞEN velat,aktar fesih,karabel müsemma,yolbaş ilyas,gözü pirinççioğlu ayfer,SOKER MURAT Evaluation of Hematological Parameters of Children Diagnosed withCOVID-19: Single-Center Experience. Turkish archives of pediatrics (Online) 56, no.5 (2021): 463 - 468. 10.5152/TurkArchPediatr.2021.21076
MLA üzel veysiye hülya,Yılmaz Kamil,ŞEN velat,aktar fesih,karabel müsemma,yolbaş ilyas,gözü pirinççioğlu ayfer,SOKER MURAT Evaluation of Hematological Parameters of Children Diagnosed withCOVID-19: Single-Center Experience. Turkish archives of pediatrics (Online), vol.56, no.5, 2021, ss.463 - 468. 10.5152/TurkArchPediatr.2021.21076
AMA üzel v,Yılmaz K,ŞEN v,aktar f,karabel m,yolbaş i,gözü pirinççioğlu a,SOKER M Evaluation of Hematological Parameters of Children Diagnosed withCOVID-19: Single-Center Experience. Turkish archives of pediatrics (Online). 2021; 56(5): 463 - 468. 10.5152/TurkArchPediatr.2021.21076
Vancouver üzel v,Yılmaz K,ŞEN v,aktar f,karabel m,yolbaş i,gözü pirinççioğlu a,SOKER M Evaluation of Hematological Parameters of Children Diagnosed withCOVID-19: Single-Center Experience. Turkish archives of pediatrics (Online). 2021; 56(5): 463 - 468. 10.5152/TurkArchPediatr.2021.21076
IEEE üzel v,Yılmaz K,ŞEN v,aktar f,karabel m,yolbaş i,gözü pirinççioğlu a,SOKER M "Evaluation of Hematological Parameters of Children Diagnosed withCOVID-19: Single-Center Experience." Turkish archives of pediatrics (Online), 56, ss.463 - 468, 2021. 10.5152/TurkArchPediatr.2021.21076
ISNAD üzel, veysiye hülya vd. "Evaluation of Hematological Parameters of Children Diagnosed withCOVID-19: Single-Center Experience". Turkish archives of pediatrics (Online) 56/5 (2021), 463-468. https://doi.org/10.5152/TurkArchPediatr.2021.21076