Synthesis and antimicrobial activities of some new flavonyl pro-drug esters of ampicillin

ÜNLÜSOY, Ceylan Meltem; ERTAN, Rahmiye; altanlar, nurten

Synthesis and antimicrobial activities of some new flavonyl pro-drug esters of ampicillin

Ceylan Meltem ÜNLÜSOY, (Ankara Üniversitesi, Eczacılık Fakültesi, Farmasötik Kimya Anabilim Dalı, Ankara, Türkiye)

Nurten ALTANLAR, (Ankara Üniversitesi, Eczacılık Fakültesi, Mikrobiyoloji Anabilim Dalı, Ankara, Türkiye)

Rahmiye ERTAN (Ankara Üniversitesi, Eczacılık Fakültesi, Farmasötik Kimya Anabilim Dalı, Ankara, Türkiye)

Turkish Journal of Chemistry

1 0

Yıl: 2005 Cilt: 29 Sayı: 2 Sayfa Aralığı: 187 - 191 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

Synthesis and antimicrobial activities of some new flavonyl pro-drug esters of ampicillin

Öz:

A new series of flavonyl pro-drug esters of ampicillin (Va-b) was prepared by condensing the appropriate bromomethyl flavone with ampicillin trihydrate potassium salt. Flavone derivatives and ampicillin both have good antibacterial activity. The synthesized compounds were tested for their antifungal and antibacterial activities in vitro. Both of the compounds were active against Candida krusei and Staphylococcus aureus.

Anahtar Kelime:

Konular: Mühendislik, Kimya

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

1.T.J. Mabry, K.R. Markham and M.B. Thomas,. "The Systematic Identification of Flavonoids", Springer Verlag, NY 83, Berlin-Heidelberg, 1970.
2.A. Mori, C. Nishino, N. Enoki and S. Tawata, Phytochemistry 26, 2231-34 (1987).
3.N.B. Perry and L.M. Foster, Planta Medica 60, 491-2 (1994).
4.C. Conti, D. Genovese, R. Santoro, M.L. Stein, N. Orsi and L. Fiore, Antimic. Agents Chemother. 34,460-6 (1990).
5.D.S. Zaharko, C.K. Grieshaber, J. Plowman and J.C. Cradock, Cancer Treatment Reports 70, 1415-21(1986).
6.M. Das and P. K. Ray, Biochemistry International 17, 203-9 (1988).
7.M. Gabor, Arzneim.-Forsch./Drug Res. 31, 442-5 (1981).
8.D. Nardi, A. Leonardi, R. Pennini, A. Tajana and R. Cazzulani, Arzneim.-Forsch./Drug Res. 43, 28-34(1993).
9.J. Sjövall, B. Muitfeldt, L. Magni and C.E. Nord, Scand. J. Infect. Dis. Suppl. 49, 73-84 (1986).
10.F. Sakamoto, S. Ikeda and G. Tsukamoto, Chem. Pharm. Bull. 32, 2241-48 (1984).
11.W.V. Daehne, E. Frederiksen, E. Gundersen, F. Lund, P. Morch, H.J. Petersen, K. Roholt, L. Tybring and W.O. Godtfredsen, J. Med. Chem. 13, 607-612 (1970).
12.H. Ferres and J.P. Clayton, U.S. Patent No. 3860579 (1972).
13.B. Ekström and B. Sjöberg, U.S. Patent No. 3939270 (1973).
14.F. Cramer and G.H. Elsching, Chem. Ber. 89, 1-12 (1956).
15.M. Tunçbilek and R. Ertan, Pharmazie 54, 255-259 (1999).
16.A.W. Bauer, W.M.M. Kirby, J.C. Sherris and M. Turck, Am. Clin. Pathol. 45, 493-6 (1966).

APA	ÜNLÜSOY C, altanlar n, ERTAN R (2005). Synthesis and antimicrobial activities of some new flavonyl pro-drug esters of ampicillin. , 187 - 191.
Chicago	ÜNLÜSOY Ceylan Meltem,altanlar nurten,ERTAN Rahmiye Synthesis and antimicrobial activities of some new flavonyl pro-drug esters of ampicillin. (2005): 187 - 191.
MLA	ÜNLÜSOY Ceylan Meltem,altanlar nurten,ERTAN Rahmiye Synthesis and antimicrobial activities of some new flavonyl pro-drug esters of ampicillin. , 2005, ss.187 - 191.
AMA	ÜNLÜSOY C,altanlar n,ERTAN R Synthesis and antimicrobial activities of some new flavonyl pro-drug esters of ampicillin. . 2005; 187 - 191.
Vancouver	ÜNLÜSOY C,altanlar n,ERTAN R Synthesis and antimicrobial activities of some new flavonyl pro-drug esters of ampicillin. . 2005; 187 - 191.
IEEE	ÜNLÜSOY C,altanlar n,ERTAN R "Synthesis and antimicrobial activities of some new flavonyl pro-drug esters of ampicillin." , ss.187 - 191, 2005.
ISNAD	ÜNLÜSOY, Ceylan Meltem vd. "Synthesis and antimicrobial activities of some new flavonyl pro-drug esters of ampicillin". (2005), 187-191.

APA	ÜNLÜSOY C, altanlar n, ERTAN R (2005). Synthesis and antimicrobial activities of some new flavonyl pro-drug esters of ampicillin. Turkish Journal of Chemistry, 29(2), 187 - 191.
Chicago	ÜNLÜSOY Ceylan Meltem,altanlar nurten,ERTAN Rahmiye Synthesis and antimicrobial activities of some new flavonyl pro-drug esters of ampicillin. Turkish Journal of Chemistry 29, no.2 (2005): 187 - 191.
MLA	ÜNLÜSOY Ceylan Meltem,altanlar nurten,ERTAN Rahmiye Synthesis and antimicrobial activities of some new flavonyl pro-drug esters of ampicillin. Turkish Journal of Chemistry, vol.29, no.2, 2005, ss.187 - 191.
AMA	ÜNLÜSOY C,altanlar n,ERTAN R Synthesis and antimicrobial activities of some new flavonyl pro-drug esters of ampicillin. Turkish Journal of Chemistry. 2005; 29(2): 187 - 191.
Vancouver	ÜNLÜSOY C,altanlar n,ERTAN R Synthesis and antimicrobial activities of some new flavonyl pro-drug esters of ampicillin. Turkish Journal of Chemistry. 2005; 29(2): 187 - 191.
IEEE	ÜNLÜSOY C,altanlar n,ERTAN R "Synthesis and antimicrobial activities of some new flavonyl pro-drug esters of ampicillin." Turkish Journal of Chemistry, 29, ss.187 - 191, 2005.
ISNAD	ÜNLÜSOY, Ceylan Meltem vd. "Synthesis and antimicrobial activities of some new flavonyl pro-drug esters of ampicillin". Turkish Journal of Chemistry 29/2 (2005), 187-191.