Objective: Knowing the parameters that will measure the course and follow-up of the disease inthe Covid-19 pandemic, which causes an important health problem all over the world, will makean important contribution to the understanding and management of the pathophysiology of thedisease. The ratio of eosinophils, which are one of the peripheral blood cells responsible for theresponse to parasites and allergens, to lymphocyte (ELO), appears to be a biomarker forinflammatory conditions. Similarly, it is known that D-dimer/Fibrinogen ratio (DFO) is importantto determine the severity of the disease in diseases with thromboembolic events. The aim of thisstudy was to evaluate the relationship of ELO and DFO with the course of the disease in Covid-19patients, where inflammation and thromboembolic events are at the forefront. Method: Thestudy was conducted as a retrospective data search. The research population included patientshospitalized for Covid-19 pneumonia between April and December 2020. The patients weredivided into groups as those who recovered and were discharged within 14 days, and those whorequired hospitalization for more than 14 days or died. Age, gender and comorbidities of thepatients, as well as laboratory values at the time of hospitalization were analyzed. Results: A totalof 486 patients were included in the study. Advanced age, presence of additional disease, highCRP, Ferritin, LDH and leukocyte count, and low lymphocyte count were found to be associatedwith poor prognosis in the 14-day course of the disease, while ELO value was not significant. WhileD-dimer and fibrinogen values were not different between the patients who recovered and didnot heal in the 14-day period, DFO was found to be significantly higher in both the non-healed andex-groups. The sensitivity of DFO in determining prolonged hospitalization was 66%, itsspecificity was 68%, and its sensitivity was 73%, and its specificity was 67% in determiningmortality. Conclusion: While ELO was not significant in the 14-day course of patients hospitalizedwith Covid-19 pneumonia, DFO elevation was found to be significant in showing both prolongedhospitalization and 14-day mortality.