Influence of the butylparaben administration on the oxidative stress metabolism of liver, kidney and spleen

ÖZTAŞÇI, Burcu; BARLAS, Nurhayat; Aydemir, Duygu; Ulusu, Nuray Nuriye

doi:10.1515/tjb-2020-0048

Influence of the butylparaben administration on the oxidative stress metabolism of liver, kidney and spleen

Duygu AYDEMİR, (Koç Üniversitesi, Tıp Fakültesi, Tıbbı Biyokimya Anabilim Dalı, İstanbul, Türkiye)

Nuriye Nuray ULUSU, (Koç Üniversitesi, Tıp Fakültesi, Tıbbi Biyokimya Anabilim Dalı, İstanbul, Türkiye)

Burcu ÖZTAŞÇI, (Hacettepe Üniversitesi, Fen Fakültesi, Biyoloji Bölümü, Ankara, Türkiye)

Nurhayat BARLAS (Hacettepe Üniversitesi, Fen Fakültesi, Biyoloji Bölümü, Ankara, Türkiye)

Türk Biyokimya Dergisi

3 0

Yıl: 2020 Cilt: 45 Sayı: 6 Sayfa Aralığı: 689 - 694 Metin Dili: İngilizce DOI: 10.1515/tjb-2020-0048 İndeks Tarihi: 26-10-2021

Influence of the butylparaben administration on the oxidative stress metabolism of liver, kidney and spleen

Öz:

Objectives: Butylparaben is widely used synthetic polymeras preservative in the food, pharmaceutical andcosmetic industries. Although butylparaben is metabolizedin the detoxification organs including liver and kidney,some parts of it can retain and accumulate in the body.Parabens can impair developmental and reproductivehealth, though there is not any published data related withthe influence of the butylparaben on the oxidative stressmetabolism in the detoxification organs. Therefore, weaimed to evaluate antioxidant enzyme activities in theliver, kidney and spleen of butylparaben-treated rat.Methods: Prepubertal Wistar albino male rats wereadministered with 0, 100, 200, 400 mg/kg/day butylparabenfor 28 days. After treatment, enzyme activities wereevaluated as the biomarkers of the oxidative stress.Results: Enzyme activities including glucose-phosphatedehydrogenase (G6PD), 6-phosphoglucanate dehydrogenase(6-PGD), glutathione reductase (GR), glutathiones-transferase (GST) and glutathione peroxidase (GPx) wereimpaired upon butylparaben treatment in the liver, kidneyand spleen tissues.Conclusions: Exposure to endocrine disruptors may affectenzyme activities of the detoxification organs and changethe pentose phosphate glutathione (GSH) metabolisms.According to our data oxidative stress metabolism isimpaired in the spleen, kidney and liver tissue uponbutylparaben treatment that has been indicated first timein the literature.

Anahtar Kelime:

[Bütilparabenin karaciğer, böbrek ve dalağın oksidatif stres metabolizmalarına etkisi]

Öz:

Amaç: Bütilparaben yiyecek, ilaç ve kozmetik endüstrilerinde yaygın olarak kullanılan sentetik bir polimerdir. Bütilparaben kısmen karaciğer ve böbrek gibi detoksifikasyon organları tarafından metabolize edilirler, ancak bir kısım metabolize edilmeden kalır ve vücutta birikir. Parabenlerin gelişim ve üreme sağlığına zarar verdiği bilinmektedir, ancak bütilparabenin detoksifikasyon organlarının oksidatif stres metabolizmasına etkileri henüz çalışılmamıştır. Bu nedenle çalışmamızda bütilparabene maruz kalmış sıçanların karaciğer, böbrek ve dalaklarında antioksidan enzim aktivitelerini değerlendirmeyi amaçladık. Gereçveyöntem: Prepubertal Wistar albino erkek sıçanlara 0, 100, 200, 400 mg/kg/gün butilparaben oral gavaj ile 28 gün boyunca uygulandı. Uygulamadan sonra antioksidan enzim aktiviteleri oksidatif stres biyo-belirteçleri olarak değerlendirildi. Bulgular: Dalak, karaciğer ve böbrek dokularında glikoz 6-fosfat dehidrogenaz, 6-fosfoglukanat dehidrogenaz, glutatyon reduktaz, glutatyon s-transferaz ve glutatyon peroksidaz enzimlerinin kontrol grubuna göre bozulduğu gözlemlenmiştir. Sonuç: Endokrin bozuculara maruz kalmak detoksifikasyon organlarında glutatyon ve pentoz fosfat metabolizması enzim aktivitelerini bozmaktadır. Literatürde ilk defa, sonuçlarımız oksidatif stres metabolizmasının karaciğer, dalak ve böbrek dokularında bütilparaben uygulaması nedeniyle bozulduğunu göstermiştir.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Kısa Bildiri Erişim Türü: Erişime Açık

1. Maske P, Dighe V, Vanage G. n-butylparaben exposure during perinatal period impairs fertility of the F1 generation female rats. Chemosphere 2018;213:114–23.
2. Boberg J, Taxvig C, Christiansen S, Hass U. Possible endocrine disrupting effects of parabens and their metabolites. Reprod Toxicol 2010;30:301–12.
3. Soni MG, Carabin IG, Burdock GA. Safety assessment of esters of p-hydroxybenzoic acid (parabens). Food Chem Toxicol 2005;43: 985–1015.
4. Oana A, Eliza D, Marina G, Daniel G, Rogoveanud O, Varut M, et al. Six months exposure to a real life mixture of 13 chemicals’ below individual NOAELs induced non monotonic sex-dependent biochemical and redox status changes in rats. Food Chem Toxicol 2018;15:470–81.
5. Garcia T, Schreiber E, Kumar V, Prasad R, Sirvent JJ, Domingo JL, et al. Effects on the reproductive system of young male rats of subcutaneous exposure to n-butylparaben. Food Chem Toxicol 2017;106:47–57.
6. Yang YJ, Hong YP, Chae SA. Reduction in semen quality after mixed exposure to bisphenol A and isobutylparaben in utero and during lactation periods. Hum Exp Toxicol 2016;35:902–11.
7. NIEHS - National Institute of Environmental Health Sciences. Available from: http://www.niehs.nih.gov/health/topics/agents/ endocrine/ 18 February 2015.
8. Boberg J, Taxvig C, Christiansen S, Hass U. Possible endocrine disrupting effects of parabens and their metabolites. Reprod Toxicol 2010;30:301–12.
9. Aydemir D, Karabulut G, Şimşek G, Barlas N, Ulusu NN. Impact of the Di(2-Ethylhexyl) phthalate administration on trace element and mineral levels in relation of kidney and liver damage in rats. Biol Trace Elem Res 2018;186:474–88.
10. Aydemir D, Karabulut G, Şimşek G, Barlas N, Ulusu NN. Data the DEHP induced changes on the trace element and mineral levels in the brain and testis tissues of rats. Data Brief 2019;26: 104526.
11. Aydemir D, Oztasci B, Barlas N, Ulusu NN. Effects of butylparaben on antioxidant enzyme activities and histopathological changes in rat tissues. Arh Hig Rada Toksikol 2019;70:315–24.
12. Rothfuss M,O’Donovan M, De Boeck D, Brault D, Czich A, Custer L, et al. Collaborative study on fifteen compounds in the rat-liver Comet assay integrated into 2- and 4-week repeat-dose studies. Mutat Res 2010;702:40–69.
13. Aydemir D, Hashemkhani M, Acar HY, Ulusu NN. In vitro interaction of glutathione S‐transferase‐pi enzyme with glutathione‐coated silver sulfide quantum dots: a novel method for biodetection of glutathione S‐transferase enzyme. Chem Biol Drug Des 2019;94:2094–102.
14. Beutler E. Red cell metabolism. In: A Manual of biochemical methods. New York: Grone & Stratton; 1971:66–8. pp.
15. Deborah J, Watkins K, Ferguson L, Anzalota Del Toro V, Cordero JF, Meeker JD, et al. Associations between urinary phenol and paraben concentrations and markers of oxidative stress and inflammation among pregnant women in Puerto Rico. Int J Hyg Environ Health 2015;218:212–9.
16. Guoyao W, Yun-Zhong F, Sheng Y, Lupton JR, Turner ND. Glutathione metabolism and its implications for health. J Nutr 2004;134:489–492
17. Aydemir D, Sarayloo E, Ulusu NN. Rosiglitazone-induced changes in the oxidative stress metabolism and fatty acid composition in relation with trace element status in the primary adipocytes. J Med Biochem 2019;38:1–9.
18. Stincone A, Prigione A, Cramer T, Wamelink MM, Campbell K, Cheung E, et al. The return of metabolism: biochemistry and physiology of the pentose phosphate pathway. Biol Rev Camb Philos Soc 2015;90:927–63. [Epub ahead of print] 2014 Sep 22.
19. Ulusu NN. Curious cases of the enzymes. J Med Biochem 2015;34: 271–81.
20. Aydemir D, Hashemkhani M, Durmusoglu EG, Yagci-Acar H, Ulusu NN. A new substrate for glutathione reductase: Glutathione coated Ag2S quantum dots. Talanta 2019;194:501–6.
21. Mebius RE, Kraal G. Structure and function of the spleen. Nat Rev Immunol 2005;5:606–16.
22. Zhang ZZ, Lee EE, Sudderth J, Yue AZ, Glass D, Deberardinis RJ, et al. Glutathione depletion, pentose phosphate pathway activation, and hemolysis in erythrocytes protecting cancer cells from vitamin C-induced oxidative stress. J Biol Chem 2016;44: 22861–7.
23. Aydemir D, Ulusu NN. Comment on the: molecular mechanism of CAT and SOD activity change under MPA-CdTe quantum dots induced oxidative stress in the mouse primary hepatocytes (Spectrochim Acta A Mol Biomol Spectrosc. 2019 Sep 5; 220: 117104). Spectrochım Acta A 2020;229:117792.

APA	Aydemir D, Ulusu N, ÖZTAŞÇI B, BARLAS N (2020). Influence of the butylparaben administration on the oxidative stress metabolism of liver, kidney and spleen. , 689 - 694. 10.1515/tjb-2020-0048
Chicago	Aydemir Duygu,Ulusu Nuray Nuriye,ÖZTAŞÇI Burcu,BARLAS Nurhayat Influence of the butylparaben administration on the oxidative stress metabolism of liver, kidney and spleen. (2020): 689 - 694. 10.1515/tjb-2020-0048
MLA	Aydemir Duygu,Ulusu Nuray Nuriye,ÖZTAŞÇI Burcu,BARLAS Nurhayat Influence of the butylparaben administration on the oxidative stress metabolism of liver, kidney and spleen. , 2020, ss.689 - 694. 10.1515/tjb-2020-0048
AMA	Aydemir D,Ulusu N,ÖZTAŞÇI B,BARLAS N Influence of the butylparaben administration on the oxidative stress metabolism of liver, kidney and spleen. . 2020; 689 - 694. 10.1515/tjb-2020-0048
Vancouver	Aydemir D,Ulusu N,ÖZTAŞÇI B,BARLAS N Influence of the butylparaben administration on the oxidative stress metabolism of liver, kidney and spleen. . 2020; 689 - 694. 10.1515/tjb-2020-0048
IEEE	Aydemir D,Ulusu N,ÖZTAŞÇI B,BARLAS N "Influence of the butylparaben administration on the oxidative stress metabolism of liver, kidney and spleen." , ss.689 - 694, 2020. 10.1515/tjb-2020-0048
ISNAD	Aydemir, Duygu vd. "Influence of the butylparaben administration on the oxidative stress metabolism of liver, kidney and spleen". (2020), 689-694. https://doi.org/10.1515/tjb-2020-0048

APA	Aydemir D, Ulusu N, ÖZTAŞÇI B, BARLAS N (2020). Influence of the butylparaben administration on the oxidative stress metabolism of liver, kidney and spleen. Türk Biyokimya Dergisi, 45(6), 689 - 694. 10.1515/tjb-2020-0048
Chicago	Aydemir Duygu,Ulusu Nuray Nuriye,ÖZTAŞÇI Burcu,BARLAS Nurhayat Influence of the butylparaben administration on the oxidative stress metabolism of liver, kidney and spleen. Türk Biyokimya Dergisi 45, no.6 (2020): 689 - 694. 10.1515/tjb-2020-0048
MLA	Aydemir Duygu,Ulusu Nuray Nuriye,ÖZTAŞÇI Burcu,BARLAS Nurhayat Influence of the butylparaben administration on the oxidative stress metabolism of liver, kidney and spleen. Türk Biyokimya Dergisi, vol.45, no.6, 2020, ss.689 - 694. 10.1515/tjb-2020-0048
AMA	Aydemir D,Ulusu N,ÖZTAŞÇI B,BARLAS N Influence of the butylparaben administration on the oxidative stress metabolism of liver, kidney and spleen. Türk Biyokimya Dergisi. 2020; 45(6): 689 - 694. 10.1515/tjb-2020-0048
Vancouver	Aydemir D,Ulusu N,ÖZTAŞÇI B,BARLAS N Influence of the butylparaben administration on the oxidative stress metabolism of liver, kidney and spleen. Türk Biyokimya Dergisi. 2020; 45(6): 689 - 694. 10.1515/tjb-2020-0048
IEEE	Aydemir D,Ulusu N,ÖZTAŞÇI B,BARLAS N "Influence of the butylparaben administration on the oxidative stress metabolism of liver, kidney and spleen." Türk Biyokimya Dergisi, 45, ss.689 - 694, 2020. 10.1515/tjb-2020-0048
ISNAD	Aydemir, Duygu vd. "Influence of the butylparaben administration on the oxidative stress metabolism of liver, kidney and spleen". Türk Biyokimya Dergisi 45/6 (2020), 689-694. https://doi.org/10.1515/tjb-2020-0048