TY  - JOUR
TI  - Influence of the butylparaben administration on the oxidative stress metabolism of liver, kidney and spleen
AB  - Objectives: Butylparaben is widely used synthetic polymeras preservative in the food, pharmaceutical andcosmetic industries. Although butylparaben is metabolizedin the detoxification organs including liver and kidney,some parts of it can retain and accumulate in the body.Parabens can impair developmental and reproductivehealth, though there is not any published data related withthe influence of the butylparaben on the oxidative stressmetabolism in the detoxification organs. Therefore, weaimed to evaluate antioxidant enzyme activities in theliver, kidney and spleen of butylparaben-treated rat.Methods: Prepubertal Wistar albino male rats wereadministered with 0, 100, 200, 400 mg/kg/day butylparabenfor 28 days. After treatment, enzyme activities wereevaluated as the biomarkers of the oxidative stress.Results: Enzyme activities including glucose-phosphatedehydrogenase (G6PD), 6-phosphoglucanate dehydrogenase(6-PGD), glutathione reductase (GR), glutathiones-transferase (GST) and glutathione peroxidase (GPx) wereimpaired upon butylparaben treatment in the liver, kidneyand spleen tissues.Conclusions: Exposure to endocrine disruptors may affectenzyme activities of the detoxification organs and changethe pentose phosphate glutathione (GSH) metabolisms.According to our data oxidative stress metabolism isimpaired in the spleen, kidney and liver tissue uponbutylparaben treatment that has been indicated first timein the literature.
AU  - ÖZTAŞÇI, Burcu
AU  - BARLAS, Nurhayat
AU  - Aydemir, Duygu
AU  - Ulusu, Nuray Nuriye
DO  - 10.1515/tjb-2020-0048
PY  - 2020
JO  - Türk Biyokimya Dergisi
VL  - 45
IS  - 6
SN  - 1303-829X
SP  - 689
EP  - 694
DB  - TRDizin
UR  - http://search/yayin/detay/455161
ER  -