At the beginning of the XIXth century, the relations between the Ottoman Empire and the Safavid State continued at the point of struggle with Russia, the common rival and enemy of the two countries. During this period, the Qajar Dynasty came to power in Iran and a tripartite alliance was tried to be established with the initiatives of France, and mutual envoys were exchanged. The Ottoman State sent Mehmet Refi Efendi to Iran in 1807 to hold diplomatic talks about the tripartite alliance initiative. Mehmet Refi Efendi, who is described as "an awake person who knows political affairs and manners" in the sources, presented his observations and memories during his tenure as ambassador to the Ottoman central administration on his return. Therefore, he has two ambassadorial reports regarding his post in Iran. Those ambassadorial reports are available as manuscripts in various libraries, as well as a printed copy published in the Ottoman History Council Journal in 1914. Mehmet Refi Efendi gives detailed information about that period of Ottoman-Iranian relations in his Sefaretnâme. In 1806, the Ottoman Empire and Iran, with the encouragement of France, decided to declare war on Russia. Thus, the Ottoman Empire and Iran went into war with Russia, which brought the two states closer to each other. The observations and information given by Mehmet Refi Efendi, who was sent to Iran in such a period, are important. In this study, firstly, after giving information about Ottoman-Iran relations at the beginning of the 19th century, in the light of Mehmet Refi Efendi's life and his ambassadorial reports, his tenure as ambassador to Iran and Ottoman-Iran relations of the period were examined.