Aim: We emphasize the importance of serum native thiol (SH), lipid peroxidation (LOOH), and ceruloplasmin (CP) levels in themanagement of patients with a migraine attack and clarify the possible relationships among these parameters in the emergencydepartment (ED)Methods: The study was designed as a case-control study which is a type of observational study by including the patients who appliedto the University of Health Sciences Turkey, University Diyarbakır Gazi Yasargil Training and Research Hospital between December 2018and July 2019. A total of 88 participants (study group, n=46 and healthy control group, n=42) consecutively admitted to the ED. withsimilar demographic characteristics were included in the study. SH, LOOH, and CP levels in both groups were recorded and studied.Results: The serum SH level was significantly lower in the patient than in the control group (p=0.002). However, the LOOH andCP levels were significantly higher in the patient group than in the control group (p<0.001). A significant correlation was observedbetween LOOH and CP (r=0.332, p=0.002). The receiver operating characteristic analysis indicated that a serum LOOH level of 11.9μmol/L predicted an acute migraine attack with 89% sensitivity and 71% specificity.Conclusions: Our results suggest that the oxidative status is activated in patients with a non-aura migraine attack, and this may lead toother oxidative and inflammatory processes, with an increase in the serum LOOH level and a decrease in the native thiol level.