TY  - JOUR
TI  - Endocan and Asymmetric Dimethylarginine as an Etiological Indicator in the Maternal and Umbilical Cord Serum in Pre-Eclampsia
AB  - Aim: Preeclampsia is a pregnancy-specific disease of unknown etiology. This study was planned to determine the place of asymmetricdimethylarginine (N, N-dimethylarginine, ADMA) and endothelial cell specific molecule-1 (ESM1, endocan) levels in etiology. The aim ofthis study was to determine ADMA and endocan levels in maternal and fetal umbilical cord serum of patients with preeclampsia andto evaluate them with clinical data.Methods: This case-control study was conducted between June and December 2020. The clinical and demographic characteristics ofthe participants were evaluated in the department of obstetrics and gynecology. Thirty-tree women with preeclampsia and 55 healthywomen in the same age group were included in our study. Serum ADMA and endocan values were determined by the ELISA method.Results: Maternal and umbilical cord ADMA levels in the preeclampsia group were statistically significantly higher than the controlgroup (p=0.001, p=0.001, respectively). Likewise, the levels of the umbilical cord and maternal serum endocan were statisticallysignificantly higher in the preeclampsia group compared to the control group (p=0.001, p=0.037, respectively).Conclusion: We found that ADMA and endocan molecules associated with endothelial dysfunction in the pathogenesis of preeclampsiasignificantly increased in maternal and umbilical cord serum
AU  - KİRMİZİ, Demet Aydogan
AU  - BASER, Emre
AU  - INANDİKLİOGLU, Nihal
DO  - 10.4274/haseki.galenos.2021.7101
PY  - 2021
JO  - Haseki Tıp Bülteni
VL  - 59
IS  - 4
SN  - 1302-0072
SP  - 308
EP  - 312
DB  - TRDizin
UR  - http://search/yayin/detay/457711
ER  -