Yıl: 2021 Cilt: 59 Sayı: 4 Sayfa Aralığı: 313 - 318 Metin Dili: İngilizce DOI: 10.4274/haseki.galenos.2021.7217 İndeks Tarihi: 04-11-2021

Risk Factors and Seroprevalence of Syphilis Among Naive HIV Patients: A Cross-Sectional Study From a Tertiary Center

Öz:
Aim: Syphilis coinfection is common among human immune deficiency virus (HIV)/acquired immune deficiency syndrome (AIDS)diagnosed patients. We aimed to investigate the rates of syphilis coinfection, social-demographical features, viral and immunologicalproperties among naive HIV/AIDS patients.Methods: Socio-demographical data, CD4+ T lymphocyte counts, HIV viral load, syphilis antibody results and physical examinations atthe time of diagnosis of naive HIV infected patients who were admitted to our center between January 2017 and January 2021, wereevaluated retrospectively from the medical records.Results: Three hundred-two naive HIV patients were enrolled in the study. Positive syphilis antibody rate was detected as 21.5% and86.2% of those patients were male and also found 31.4% (p<0.01) in patients in which route of transmission was men sex with men(MSM). Positive syphilis antibody rate was found to be statistically higher in patients with substance abuse (p<0.01), CD4+ T lymphocytecounts were under 200 cell/mm³ (p=0.018) and viral load above 100.000 copies/mL (p<0.01).Conclusion: Among HIV-infected patients, those with MSM and substance abuse constitute the group at highest risk of syphilis.Therefore, syphilis must be screened and treated, especially at HIV diagnosis and high-risk behaviors.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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  • 1. Tudor ME, Al Aboud AM, Gossman WG. Syphilis. Last Updated March 22, 2021. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing. Available from: https://www.ncbi.nlm. nih.gov/books/NBK534780/. Accessed May 6, 2021.
  • 2. Maan I, Lawrence DS, Tlhako N, et al. Using a dual antibody point-of-care test with visual and digital reads to diagnose syphilis among people living with HIV in Botswana. Int J STD AIDS 2021;32:453-61.
  • 3. Kotsafti O, Paparizos V, Kourkounti S, Chatziioannou A, Nicolaidou E, Kapsimali V, Antoniou C. Early syphilis affects markers of HIV infection. Int J STD AIDS 2016;27:739-45.
  • 4. Frunza-Stefan S, Acharya G, Kazlouskaya V, Vukasinov P, Chiou Y, Thet Z. Immune reconstitution inflammatory syndrome associated with secondary syphilis. Int J STD AIDS 2017;28:302-5.
  • 5. TC.Sağlık Bakanlığı HIV-AIDS İstatistik Available from: https:// hsgm.saglik.gov.tr/tr/bulasici-hastaliklar/hiv-aids/hiv-aidsliste/hiv-aids-istatislik.html. Accessed May 6, 2021.
  • 6. Oncul O, Emekdas G, Cavuslu S, Artuk C, Aksoy A. The sixteenyear trend of syphilis in Turkey: data from blood donors. Trop Doct 2008;38:181-2.
  • 7. Akın L. Epidemiology of sexually transmitted infection: review. Turkiye Klinikleri J Med Sci 2006;26:655-65.
  • 8. Köksal MO, Beka H, Evlice O, et al. Syphilis seroprevalence among HIV-infected males in Istanbul, Turkey. Rev Argent Microbiol 2020;52:266-71.
  • 9. Karumudi UR, Augenbraun M. Syphilis and HIV: a dangerous duo. Expert Rev Anti Infect Ther 2005;3:825-31.
  • 10. European AIDS Clinical Society (EACS) Guidelines. Version 10.1 - October 2020. Available from: https://www.eacsociety. org/guidelines/eacs-guidelines/eacs-guidelines.htmlAccessed May 6, 2021.
  • 11. HIV infection: detection, counseling, and referral. Sexually transmitted diseases treatment guidelines CDC; 2021 Available from: https://www.cdc.gov/std/tg2015/hiv.htm. Accessed May 6, 2021.
  • 12. Centers for Disease Control and Prevention (CDC). Revised surveillance case definition for HIV infection--United States, 2014. MMWR Recomm Rep 2014;63(RR-03):1-10.
  • 13. French P, Gomberg M, Janier M, et al. IUSTI: 2008 European Guidelines on the Management of Syphilis. Int J STD AIDS 2009;20:300-9.
  • 14. Salado-Rasmussen K. Syphilis and HIV co-infection. Epidemiology, treatment and molecular typing of Treponema pallidum. Dan Med J 2015;62:B5176.
  • 15. TC. Sağlık Bakanlığı Halk Sağlığı Genel Müdürlüğü. HIV/AIDS Tanı Tedavi Rehberi 2019. Available from: https://hsgm.saglik. gov.tr/depo/birimler/Bulasici-hastaliklar-db/hastaliklar/HIVADS/Tani-Tedavi_Rehberi/HIV_AIDS_Tani_Tedavi_Rehberi_ Yeni.pdf.Accessed May 6, 2021.
  • 16. Staneková D, Kramárová P, Wimmerová S, Hábeková M, Takáčová M, Mojzesová M. HIV and risk behaviour among men who have sex with men in Slovakia (2008-2009). Cent Eur J Public Health 2014;22:239-44.
  • 17. Mata-Marín JA, Sandoval-Sánchez JJ, Huerta-García G, et al. Prevalence of antibodies against Treponema pallidum among HIV-positive patients in a tertiary care hospital in Mexico. Int J STD AIDS 2015;26:81-5.
  • 18. Pérez C C, Cerón A I, Fuentes L G, et al. Coinfecciones por virus hepatitis B, virus hepatitis C, Treponema pallidum y Toxoplasma gondii en la cohorte de pacientes VIH positivos en control en la Pontificia Universidad Católica de Chile [Hepatitis B, C, Treponema pallidum and Toxoplasma gondii co-infections in HIV infected patients]. Rev Med Chil 2009;137:641-8.
  • 19. Hu QH, Xu JJ, Zou HC, et al. Risk factors associated with prevalent and incident syphilis among an HIV-infected cohort in Northeast China. BMC Infect Dis 2014;14:658.
  • 20. Bernstein KT, Stephens SC, Strona FV, Kohn RP, Philip SS. Epidemiologic characteristics of an ongoing syphilis epidemic among men who have sex with men, San Francisco. Sex Transm Dis 2013;40:11-7.
  • 21. Kaptan F, Örmen B, Türker F, et al. İnsan immun yetmezlik virüsü ile enfekte 128 olgunun retrospektif olarak değerlendirilmesi. Türkiye Klinikleri J Med Sci 2011;31:525-33.
  • 22. Sayan M, Willke A, Ozgunes N, Sargın F. HIV-1 subtypes and primary antiretroviral resistance mutations in antiretroviral therapy naive HIV-1 infected individuals in Turkey. Jpn J Infect Dis 2013;66:306-11.
  • 23. Aydin ÖA, Karaosmanoğlu HK, Sayan M, İnce ER, Nazlıcan Ö. Seroprevalence and risk factors of syphilis among HIV/ AIDS patients in Istanbul, Turkey. Cent Eur J Public Health 2015;23:65-8.
  • 24. Sarigül F, Sayan M, İnan D, et al. Current status of HIV/AIDSsyphilis co-infections: a retrospective multicentre study. Cent Eur J Public Health 2019;27:223-8.
  • 25. Sarıgül F, Üser Ü, Öztoprak N. HIV/AIDS hastalarında sifilis koinfeksiyonu seroprevalansı ve risk faktörleri. Klimik Dergisi 2019;32:161-4.
  • 26. Korkusuz R, Şenoğlu S. Syphilis Seroprevalence and Associated Risk Factors in HIV-infected Individuals. Mediterr J Infect Microb Antimicrob 2020;9:13.
  • 27. United States Centers for Disease Control and Prevention. Sexually TransmittedDiseaseSurveillance2018. Available from: https://www.cdc.gov/std/stats18/default.htm Accessed May 6, 2021.
  • 28. Sayan M. Turkey’s HIV dynamics and the patient universe. In: HIV epi¬demiological status and prevention strategies in Turkey: KLIMIK HIV Study Group Meeting 2017 Oct 14; Istanbul, Turkey Available from: https://www.klimik.org.tr.
  • 29. Pines HA, Wertheim JO, Liu L, Garfein RS, Little SJ, Karris MY. Concurrency and HIV transmission network characteristics among MSM with recent HIV infection. AIDS 2016;3:2875- 83.
  • 30. Tong ML, Lin LR, Liu LL, et al. Analysis of 3 algorithms for syphilis serodiagnosis and implications for clinical management. Clin Infect Dis 2014;58:1116-24.
  • 31. Forsyth AD, Valdiserri RO. A State-Level Analysis of Social and Structural Factors and HIV Outcomes Among Men Who Have Sex With Men in the United States. AIDS Educ Prev 2015;27:493-504.
  • 32. Jarzebowski W, Caumes E, Dupin N, et al. Effect of early syphilis infection on plasma viral load and CD4 cell count in human immunodeficiency virus-infected men: results from the FHDH-ANRS CO4 cohort. Arch Intern Med 2012;172:1237- 43.
  • 33. Farhi D, Dupin N. Management of syphilis in the HIV-infected patient: facts and controversies. Clin Dermatol 2010;28:539- 45.
  • 34. Rompalo AM, Joesoef MR, O’Donnell JA, et al. Clinical manifestations of early syphilis by HIV status and gender: results of the syphilis and HIV study. Sex Transm Dis 2001;28:158-65.
APA OZDEMİR H, Tosun S, BOZACİ I (2021). Risk Factors and Seroprevalence of Syphilis Among Naive HIV Patients: A Cross-Sectional Study From a Tertiary Center. , 313 - 318. 10.4274/haseki.galenos.2021.7217
Chicago OZDEMİR Hulya Ozkan,Tosun Selma,BOZACİ Ilter Risk Factors and Seroprevalence of Syphilis Among Naive HIV Patients: A Cross-Sectional Study From a Tertiary Center. (2021): 313 - 318. 10.4274/haseki.galenos.2021.7217
MLA OZDEMİR Hulya Ozkan,Tosun Selma,BOZACİ Ilter Risk Factors and Seroprevalence of Syphilis Among Naive HIV Patients: A Cross-Sectional Study From a Tertiary Center. , 2021, ss.313 - 318. 10.4274/haseki.galenos.2021.7217
AMA OZDEMİR H,Tosun S,BOZACİ I Risk Factors and Seroprevalence of Syphilis Among Naive HIV Patients: A Cross-Sectional Study From a Tertiary Center. . 2021; 313 - 318. 10.4274/haseki.galenos.2021.7217
Vancouver OZDEMİR H,Tosun S,BOZACİ I Risk Factors and Seroprevalence of Syphilis Among Naive HIV Patients: A Cross-Sectional Study From a Tertiary Center. . 2021; 313 - 318. 10.4274/haseki.galenos.2021.7217
IEEE OZDEMİR H,Tosun S,BOZACİ I "Risk Factors and Seroprevalence of Syphilis Among Naive HIV Patients: A Cross-Sectional Study From a Tertiary Center." , ss.313 - 318, 2021. 10.4274/haseki.galenos.2021.7217
ISNAD OZDEMİR, Hulya Ozkan vd. "Risk Factors and Seroprevalence of Syphilis Among Naive HIV Patients: A Cross-Sectional Study From a Tertiary Center". (2021), 313-318. https://doi.org/10.4274/haseki.galenos.2021.7217
APA OZDEMİR H, Tosun S, BOZACİ I (2021). Risk Factors and Seroprevalence of Syphilis Among Naive HIV Patients: A Cross-Sectional Study From a Tertiary Center. Haseki Tıp Bülteni, 59(4), 313 - 318. 10.4274/haseki.galenos.2021.7217
Chicago OZDEMİR Hulya Ozkan,Tosun Selma,BOZACİ Ilter Risk Factors and Seroprevalence of Syphilis Among Naive HIV Patients: A Cross-Sectional Study From a Tertiary Center. Haseki Tıp Bülteni 59, no.4 (2021): 313 - 318. 10.4274/haseki.galenos.2021.7217
MLA OZDEMİR Hulya Ozkan,Tosun Selma,BOZACİ Ilter Risk Factors and Seroprevalence of Syphilis Among Naive HIV Patients: A Cross-Sectional Study From a Tertiary Center. Haseki Tıp Bülteni, vol.59, no.4, 2021, ss.313 - 318. 10.4274/haseki.galenos.2021.7217
AMA OZDEMİR H,Tosun S,BOZACİ I Risk Factors and Seroprevalence of Syphilis Among Naive HIV Patients: A Cross-Sectional Study From a Tertiary Center. Haseki Tıp Bülteni. 2021; 59(4): 313 - 318. 10.4274/haseki.galenos.2021.7217
Vancouver OZDEMİR H,Tosun S,BOZACİ I Risk Factors and Seroprevalence of Syphilis Among Naive HIV Patients: A Cross-Sectional Study From a Tertiary Center. Haseki Tıp Bülteni. 2021; 59(4): 313 - 318. 10.4274/haseki.galenos.2021.7217
IEEE OZDEMİR H,Tosun S,BOZACİ I "Risk Factors and Seroprevalence of Syphilis Among Naive HIV Patients: A Cross-Sectional Study From a Tertiary Center." Haseki Tıp Bülteni, 59, ss.313 - 318, 2021. 10.4274/haseki.galenos.2021.7217
ISNAD OZDEMİR, Hulya Ozkan vd. "Risk Factors and Seroprevalence of Syphilis Among Naive HIV Patients: A Cross-Sectional Study From a Tertiary Center". Haseki Tıp Bülteni 59/4 (2021), 313-318. https://doi.org/10.4274/haseki.galenos.2021.7217