Could Lycopene Protect Against Ischemia/Reperfusion Injury in the Uterus?
Yıl: 2021 Cilt: 22 Sayı: 2 Sayfa Aralığı: 155 - 160 Metin Dili: İngilizce DOI: 10.4274/imj.galenos.2021.82698 İndeks Tarihi: 06-11-2021
Could Lycopene Protect Against Ischemia/Reperfusion Injury in the Uterus?
Öz: Introduction: Ischemia/reperfusion damage (IRD) is one of themost important factors in the success of organ transplantation.IRD plays a role in both acute and chronic rejection. This studyaims to evaluate the effects of lycopene, which is known to bea powerful antioxidant, on experimental uterine IRD.Methods: Twenty-four albino Wistar rats were included inthe study and divided into three groups. No substances wereadministered the sham and ischemia/reperfusion groups. Theischemia/reperfusion and ischemia/reperfusion + lycopenegroups were administered ischemia for 1 h and reperfusionfor 2 h. The ischemia/reperfusion + lycopene group wasadministered 2.5 mg/kg lycopene reperfusion intraperitoneallyhalf an hour before ischemia/reperfusion. Both uterine hornswere extracted at the end of the procedure. Oxidative stress,inflammation, and apoptosis in the tissues were assessed.Results: The malondialdehyde level, nuclear factor kappa-Bimmunoreactivity, and apoptotic cell number in the lycopeneadministered group (ischemia/reperfusion + lycopene) weresignificantly decreased compared with those in the ischemia/reperfusion group (p<0.05).Conclusion: The study found that lycopene reduced the effectsof IRD on uterine tissue. Lycopene may positively affect theshort- and long-term success of organ transplantation.
Anahtar Kelime: Likopen Uterustaki İskemi/Reperfüzyon Hasarına Karşı Koruyabilir mi?
Öz: Amaç: İskemi/reperfüzyon hasarı (İRH) organ transplantasyonunun başarısının önündeki en önemli etkenlerden biridir. İRH hem akut hem de kronik rejeksiyonda rol oynamaktadır. Bu çalışmanın amacı güçlü bir antioksidan olduğu bilinen likopenin deneysel uterus İRH’de etkilerini değerlendirmektir. Yöntemler: Çalışmaya alınan 24 Wistar albino rat 3 gruba ayrılmıştır. Sham ve iskemi/reperfüzyon grubuna hiçbir madde verilmemiştir. İskemi/reperfüzyon ve iskemi/reperfüzyon + likopen grubuna 1 saat iskemi ve 2 saat reperfüzyon uygulanmıştır. İskemi/reperfüzyon + likopen grubuna 2,5 mg/ kg dozda likopen reperfüzyon yarım saat önce intraperitoneal olarak verilmiştir. İşlemin sonunda her iki uterin horn çıkarılmıştır. Dokularda oksidatif stres, enflamasyon ve apoptozis değerlendirilmiştir. Bulgular: Likopen uygulanan grupta (iskemi/reperfüzyon + likopen) malondialdehit seviyesi, nükleer faktör kappa-B immünoreaktivitesi ve apoptotik hücre sayısı iskemi/ reperfüzyon grubuna göre önemli ölçüde azalmıştır (p<0,05). Sonuç: Likopenin İRH’nin uterin doku üzerindeki etkilerini azalttığı saptanmıştır. Likopen, organ naklinin kısa ve uzun vadeli başarısını olumlu yönde etkileyebilir.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | Onat T, Doğanyiğit Z, Demir çaltekin M, Turkler C, KAYMAK E, Altındağ M (2021). Could Lycopene Protect Against Ischemia/Reperfusion Injury in the Uterus?. , 155 - 160. 10.4274/imj.galenos.2021.82698 |
| Chicago | Onat Taylan,Doğanyiğit Züleyha,Demir çaltekin Melike,Turkler Can,KAYMAK EMIN,Altındağ Mehmet Murat Could Lycopene Protect Against Ischemia/Reperfusion Injury in the Uterus?. (2021): 155 - 160. 10.4274/imj.galenos.2021.82698 |
| MLA | Onat Taylan,Doğanyiğit Züleyha,Demir çaltekin Melike,Turkler Can,KAYMAK EMIN,Altındağ Mehmet Murat Could Lycopene Protect Against Ischemia/Reperfusion Injury in the Uterus?. , 2021, ss.155 - 160. 10.4274/imj.galenos.2021.82698 |
| AMA | Onat T,Doğanyiğit Z,Demir çaltekin M,Turkler C,KAYMAK E,Altındağ M Could Lycopene Protect Against Ischemia/Reperfusion Injury in the Uterus?. . 2021; 155 - 160. 10.4274/imj.galenos.2021.82698 |
| Vancouver | Onat T,Doğanyiğit Z,Demir çaltekin M,Turkler C,KAYMAK E,Altındağ M Could Lycopene Protect Against Ischemia/Reperfusion Injury in the Uterus?. . 2021; 155 - 160. 10.4274/imj.galenos.2021.82698 |
| IEEE | Onat T,Doğanyiğit Z,Demir çaltekin M,Turkler C,KAYMAK E,Altındağ M "Could Lycopene Protect Against Ischemia/Reperfusion Injury in the Uterus?." , ss.155 - 160, 2021. 10.4274/imj.galenos.2021.82698 |
| ISNAD | Onat, Taylan vd. "Could Lycopene Protect Against Ischemia/Reperfusion Injury in the Uterus?". (2021), 155-160. https://doi.org/10.4274/imj.galenos.2021.82698 |
| APA | Onat T, Doğanyiğit Z, Demir çaltekin M, Turkler C, KAYMAK E, Altındağ M (2021). Could Lycopene Protect Against Ischemia/Reperfusion Injury in the Uterus?. İstanbul Medical Journal, 22(2), 155 - 160. 10.4274/imj.galenos.2021.82698 |
| Chicago | Onat Taylan,Doğanyiğit Züleyha,Demir çaltekin Melike,Turkler Can,KAYMAK EMIN,Altındağ Mehmet Murat Could Lycopene Protect Against Ischemia/Reperfusion Injury in the Uterus?. İstanbul Medical Journal 22, no.2 (2021): 155 - 160. 10.4274/imj.galenos.2021.82698 |
| MLA | Onat Taylan,Doğanyiğit Züleyha,Demir çaltekin Melike,Turkler Can,KAYMAK EMIN,Altındağ Mehmet Murat Could Lycopene Protect Against Ischemia/Reperfusion Injury in the Uterus?. İstanbul Medical Journal, vol.22, no.2, 2021, ss.155 - 160. 10.4274/imj.galenos.2021.82698 |
| AMA | Onat T,Doğanyiğit Z,Demir çaltekin M,Turkler C,KAYMAK E,Altındağ M Could Lycopene Protect Against Ischemia/Reperfusion Injury in the Uterus?. İstanbul Medical Journal. 2021; 22(2): 155 - 160. 10.4274/imj.galenos.2021.82698 |
| Vancouver | Onat T,Doğanyiğit Z,Demir çaltekin M,Turkler C,KAYMAK E,Altındağ M Could Lycopene Protect Against Ischemia/Reperfusion Injury in the Uterus?. İstanbul Medical Journal. 2021; 22(2): 155 - 160. 10.4274/imj.galenos.2021.82698 |
| IEEE | Onat T,Doğanyiğit Z,Demir çaltekin M,Turkler C,KAYMAK E,Altındağ M "Could Lycopene Protect Against Ischemia/Reperfusion Injury in the Uterus?." İstanbul Medical Journal, 22, ss.155 - 160, 2021. 10.4274/imj.galenos.2021.82698 |
| ISNAD | Onat, Taylan vd. "Could Lycopene Protect Against Ischemia/Reperfusion Injury in the Uterus?". İstanbul Medical Journal 22/2 (2021), 155-160. https://doi.org/10.4274/imj.galenos.2021.82698 |
