TY  - JOUR
TI  - Could Lycopene Protect Against Ischemia/Reperfusion Injury in the Uterus?
AB  - Introduction: Ischemia/reperfusion damage (IRD) is one of themost important factors in the success of organ transplantation.IRD plays a role in both acute and chronic rejection. This studyaims to evaluate the effects of lycopene, which is known to bea powerful antioxidant, on experimental uterine IRD.Methods: Twenty-four albino Wistar rats were included inthe study and divided into three groups. No substances wereadministered the sham and ischemia/reperfusion groups. Theischemia/reperfusion and ischemia/reperfusion + lycopenegroups were administered ischemia for 1 h and reperfusionfor 2 h. The ischemia/reperfusion + lycopene group wasadministered 2.5 mg/kg lycopene reperfusion intraperitoneallyhalf an hour before ischemia/reperfusion. Both uterine hornswere extracted at the end of the procedure. Oxidative stress,inflammation, and apoptosis in the tissues were assessed.Results: The malondialdehyde level, nuclear factor kappa-Bimmunoreactivity, and apoptotic cell number in the lycopeneadministered group (ischemia/reperfusion + lycopene) weresignificantly decreased compared with those in the ischemia/reperfusion group (p<0.05).Conclusion: The study found that lycopene reduced the effectsof IRD on uterine tissue. Lycopene may positively affect theshort- and long-term success of organ transplantation.
AU  - Turkler, Can
AU  - Onat, Taylan
AU  - Demir çaltekin, Melike
AU  - Doğanyiğit, Züleyha
AU  - Altındağ, Mehmet Murat
AU  - KAYMAK, EMIN
DO  - 10.4274/imj.galenos.2021.82698
PY  - 2021
JO  - İstanbul Medical Journal
VL  - 22
IS  - 2
SN  - 2619-9793
SP  - 155
EP  - 160
DB  - TRDizin
UR  - http://search/yayin/detay/458374
ER  -