Development and in-vitro evaluation of chitosan chloridedecorated PLGA based polymeric nanoparticles ofnimesulide

Ceyda Tuba ŞENGEL TÜRK, (Ankara Üniversitesi, Eczacılık Fakültesi, Eczacılık Teknolojisi Anabilim Dalı, Ankara, Türkiye)
Bilge BAYRAM (Tokat Devlet Hastanesi, Tokat, Türkiye)
Journal of research in pharmacy (online)
8 0
Yıl: 2021 Cilt: 25 Sayı: 4 Sayfa Aralığı: 379 - 387 Metin Dili: İngilizce DOI: 10.29228/jrp.28 İndeks Tarihi: 07-11-2021

Development and in-vitro evaluation of chitosan chloridedecorated PLGA based polymeric nanoparticles ofnimesulide

Öz:
The aim of this study is to develop PLGA based nanoparticle drug delivery systems loaded with nimesulide which is a non-steroidal anti-inflammatory (NSAI) agent and a selective COX-2 inhibitor that proved its antineoplastic and antitumor activity on cancer carsinogenesis and chemotherapy via epidemiological, pathological, clinical and biological studies in the last years, and modify their surface properties using chitosan chloride. For this purpose, Nimesulide loaded PLGA nanoparticles modified with chitosan chloride were developed with solvent evaporation-diffusion-salting out method. Nanoparticle formulations were evaluated for production yield, process efficacy, particle size and polydispersity index (PDI), surface charge, morphologic properties, redispersibility index, residual PVA amount and in vitro dissolution rate profiles. The results obtained showed that surface modification with chitosan chloride was significantly effective statistically on the final properties of the nanoparticles. With this study, it was shown that PVA and chitosan chloride combined can play a key role in developing cationic and positively charged nanoparticles.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA SENGEL-TURK C, BAYRAM B (2021). Development and in-vitro evaluation of chitosan chloridedecorated PLGA based polymeric nanoparticles ofnimesulide. , 379 - 387. 10.29228/jrp.28
Chicago SENGEL-TURK CEYDA TUBA,BAYRAM Bilge Development and in-vitro evaluation of chitosan chloridedecorated PLGA based polymeric nanoparticles ofnimesulide. (2021): 379 - 387. 10.29228/jrp.28
MLA SENGEL-TURK CEYDA TUBA,BAYRAM Bilge Development and in-vitro evaluation of chitosan chloridedecorated PLGA based polymeric nanoparticles ofnimesulide. , 2021, ss.379 - 387. 10.29228/jrp.28
AMA SENGEL-TURK C,BAYRAM B Development and in-vitro evaluation of chitosan chloridedecorated PLGA based polymeric nanoparticles ofnimesulide. . 2021; 379 - 387. 10.29228/jrp.28
Vancouver SENGEL-TURK C,BAYRAM B Development and in-vitro evaluation of chitosan chloridedecorated PLGA based polymeric nanoparticles ofnimesulide. . 2021; 379 - 387. 10.29228/jrp.28
IEEE SENGEL-TURK C,BAYRAM B "Development and in-vitro evaluation of chitosan chloridedecorated PLGA based polymeric nanoparticles ofnimesulide." , ss.379 - 387, 2021. 10.29228/jrp.28
ISNAD SENGEL-TURK, CEYDA TUBA - BAYRAM, Bilge. "Development and in-vitro evaluation of chitosan chloridedecorated PLGA based polymeric nanoparticles ofnimesulide". (2021), 379-387. https://doi.org/10.29228/jrp.28
APA SENGEL-TURK C, BAYRAM B (2021). Development and in-vitro evaluation of chitosan chloridedecorated PLGA based polymeric nanoparticles ofnimesulide. Journal of research in pharmacy (online), 25(4), 379 - 387. 10.29228/jrp.28
Chicago SENGEL-TURK CEYDA TUBA,BAYRAM Bilge Development and in-vitro evaluation of chitosan chloridedecorated PLGA based polymeric nanoparticles ofnimesulide. Journal of research in pharmacy (online) 25, no.4 (2021): 379 - 387. 10.29228/jrp.28
MLA SENGEL-TURK CEYDA TUBA,BAYRAM Bilge Development and in-vitro evaluation of chitosan chloridedecorated PLGA based polymeric nanoparticles ofnimesulide. Journal of research in pharmacy (online), vol.25, no.4, 2021, ss.379 - 387. 10.29228/jrp.28
AMA SENGEL-TURK C,BAYRAM B Development and in-vitro evaluation of chitosan chloridedecorated PLGA based polymeric nanoparticles ofnimesulide. Journal of research in pharmacy (online). 2021; 25(4): 379 - 387. 10.29228/jrp.28
Vancouver SENGEL-TURK C,BAYRAM B Development and in-vitro evaluation of chitosan chloridedecorated PLGA based polymeric nanoparticles ofnimesulide. Journal of research in pharmacy (online). 2021; 25(4): 379 - 387. 10.29228/jrp.28
IEEE SENGEL-TURK C,BAYRAM B "Development and in-vitro evaluation of chitosan chloridedecorated PLGA based polymeric nanoparticles ofnimesulide." Journal of research in pharmacy (online), 25, ss.379 - 387, 2021. 10.29228/jrp.28
ISNAD SENGEL-TURK, CEYDA TUBA - BAYRAM, Bilge. "Development and in-vitro evaluation of chitosan chloridedecorated PLGA based polymeric nanoparticles ofnimesulide". Journal of research in pharmacy (online) 25/4 (2021), 379-387. https://doi.org/10.29228/jrp.28
Sayfa Oluşturulma Tarihi
23-04-2024 20:2

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