TY  - JOUR
TI  - The relationship between anxiety and serum Urotensin-II and S100B levels in patients with essential hypertension
AB  - Objective: In hypertensive people, some biochemicalparameters that are associated with oxidative stress andendothelial functions may play a role in the manifestation of anxiety symptoms, and even in the intensificationof clinical symptoms of the disease. The purpose of ourcorrelative study is to examine the association betweenanxiety severity and levels of oxidative stress parametersof Urotensin-II and S100B protein in patients with essential hypertension. Method: A total of 153 patients, whohave applied Sociodemographic and Clinical Data Form,Beck Anxiety Inventory (BAI), Beck Depression Inventoryand venous blood samples were taken after blood pressure measurement. S100B and Urotensin-II levels weremeasured with Enzyme-Linked Immunosorbent Assaymethod. Results: A positive correlation was determinedbetween depression and anxiety scores, and systolicblood pressure (p=0.049, r= 0.160; p<0.01, r=0.292).There was a positive relation between BAI scores andUrotensin-II levels (p= 0.043, r= 0.164). A positive correlation was determined between Urotensin-II levels andS100B levels (p<0.01, r= 0.711). A statistically significant difference was observed in serum Urotensin-II levelsbetween depression group and no depression group(p=0.017). Discussion: It was determined in our studythat Urotensin-II level increased with increasing anxietylevel in essential hypertension patients. It was also determined that Urotensin-II level was higher in hypertensivepatients with depression compared to patients whodon't have depression. Our study will shed light on newstudies that will investigate the contribution ofUrotensin- II and S100B in the etiology of patients diagnosed with essential hypertension, which is very commonly accompanied by anxiety and depressive symptoms.
AU  - TELO, Selda
AU  - Atmaca, Murad
AU  - KORKMAZ, HASAN
AU  - KORKMAZ, SEVDA
AU  - Kazğan Kılıçaslan, Aslı
AU  - Yildiz, Sevler
DO  - 10.5505/kpd.2021.67044
PY  - 2021
JO  - Klinik Psikiyatri Dergisi
VL  - 24
IS  - 3
SN  - 1302-0099
SP  - 315
EP  - 323
DB  - TRDizin
UR  - http://search/yayin/detay/459039
ER  -