The Effects of Vitamin D Level on Bone Lesions and Prognostic Factors in Multiple Myeloma
Yıl: 2021 Cilt: 22 Sayı: 2 Sayfa Aralığı: 196 - 202 Metin Dili: İngilizce DOI: 10.4274/meandros.galenos.2021.94557 İndeks Tarihi: 10-11-2021
The Effects of Vitamin D Level on Bone Lesions and Prognostic Factors in Multiple Myeloma
Öz: Objective: Several studies have found that low vitamin D levels are associatedwith an increased risk of hematologic malignancies and a poor prognosis. In thisstudy, we investigated the relationship between 25-hydroxyvitamin D levels andbone lesions as well as prognostic factors in patients with multiple myeloma.Materials and Methods: We evaluated 184 people who had just been diagnosedwith multiple myeloma. Complete blood count, biochemical parameters, serum25-hydroxyvitamin D [25(OH)D] level, presence of lytic bone lesion and fracture,and disease stage were all recorded. The patients were divided into three groupsbased on their 25(OH)D levels: deficient (<20 ng/mL), insufficient (20-29 ng/mL), and normal (≥30 ng/mL). SPSS-21 was used to perform statistical analyses.Results: The 25(OH)D was deficient in 121 patients (65.8%), insufficientin 28 patients (15.2%), and normal in 35 patients (19%). Age, presence oflytic bone lesion and bone fracture, plasma cell rate in bone marrow, andstage of disease (p=0.02; p=0.01; p=0.007; p=0.02, respectively) all differedsignificantly between these groups. Patients with normal 25(OH)D levelshad lower risk of lytic bone lesion and fracture. Furthermore, deficiencyand insufficiency of 25(OH)D had a negative impact on disease stage, andadvanced disease stage is a poor prognostic parameter for multiple myeloma.Conclusion: Patients with normal 25(OH)D levels have a lower risk of lytic bonelesion and vertebral fracture. The stage of the disease is influenced by 25(OH)Ddeficiency and insufficiency. Therefore, early detection and treatment of 25(OH)D deficiency and insufficiency in patients with multiple myeloma may reducemortality and morbidity rates.
Anahtar Kelime: Multipl Miyelomda D Vitamini Düzeyinin Kemik Lezyonları ve Prognostik Faktörler Üzerine Etkileri
Öz: Amaç: Birkaç çalışma, düşük D vitamini düzeyinin, hematolojik malignitelerin artmış insidansı ve kötü prognozu ile ilişkili olduğunu bildirmiştir. Biz bu çalışmada multipl miyelomlu hastalarda, 25-hidroksivitamin D [25(OH)D] düzeyi ile kemik lezyonları ve prognostik faktörler arasındaki ilişkiyi araştırdık. Gereç ve Yöntemler: Yeni tanı almış 184 multipl miyelom hastası değerlendirildi. Tam kan sayımı, biyokimyasal parametreler, serum 25(OH)D düzeyi, litik kemik lezyonu ve kırık varlığı, hastalık evresi kaydedildi. Hastalar 25(OH)D düzeyine göre 3 gruba ayrıldı; eksik (<20 ng/mL), yetersiz (20-29 ng/mL) ve normal (≥30 ng/mL). İstatistiksel değerlendirmeler SPSS-21 programı ile yapıldı.Bulgular: 25(OH)D düzeyi 121 hastada (%65,8) eksik, 28 hastada yetersiz (%15,2) ve 35 hastada (%19) normaldi. Bu gruplar arasında yaş, litik kemik lezyonu ve kırık varlığı, kemik iliğinde plazma hücre oranı ve hastalık evresi açısından anlamlı fark vardı (sırasıyla p=0,02, p=0,01, p=0,007, p=0,02 ). 25(OH)D düzeyi normal olan hastalarda litik kemik lezyonu ve kırık daha azdı. Ek olarak; 25(OH)D eksikliği ve yetersizliği hastalığın evresini olumsuz etkiledi ve hastalığın ileri evresi multipl miyelom için kötü prognostik parametredir. Sonuç: 25(OH)D düzeyi normal olan hastalarda litik kemik lezyonu ve kemik kırığı daha az görülür. 25(OH)D eksikliği ve yetersizliği hastalığın evresini olumsuz etkiler. Bu nedenle; 25(OH)D eksikliği ve yetersizliğinin erken tespiti ve tedavisi multipl miyelomlu hastalarda mortaliteyi ve morbidite oranını azaltabilir.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | SİNCAN G, ERDEM F (2021). The Effects of Vitamin D Level on Bone Lesions and Prognostic Factors in Multiple Myeloma. , 196 - 202. 10.4274/meandros.galenos.2021.94557 |
| Chicago | SİNCAN Gülden,ERDEM Fuat The Effects of Vitamin D Level on Bone Lesions and Prognostic Factors in Multiple Myeloma. (2021): 196 - 202. 10.4274/meandros.galenos.2021.94557 |
| MLA | SİNCAN Gülden,ERDEM Fuat The Effects of Vitamin D Level on Bone Lesions and Prognostic Factors in Multiple Myeloma. , 2021, ss.196 - 202. 10.4274/meandros.galenos.2021.94557 |
| AMA | SİNCAN G,ERDEM F The Effects of Vitamin D Level on Bone Lesions and Prognostic Factors in Multiple Myeloma. . 2021; 196 - 202. 10.4274/meandros.galenos.2021.94557 |
| Vancouver | SİNCAN G,ERDEM F The Effects of Vitamin D Level on Bone Lesions and Prognostic Factors in Multiple Myeloma. . 2021; 196 - 202. 10.4274/meandros.galenos.2021.94557 |
| IEEE | SİNCAN G,ERDEM F "The Effects of Vitamin D Level on Bone Lesions and Prognostic Factors in Multiple Myeloma." , ss.196 - 202, 2021. 10.4274/meandros.galenos.2021.94557 |
| ISNAD | SİNCAN, Gülden - ERDEM, Fuat. "The Effects of Vitamin D Level on Bone Lesions and Prognostic Factors in Multiple Myeloma". (2021), 196-202. https://doi.org/10.4274/meandros.galenos.2021.94557 |
| APA | SİNCAN G, ERDEM F (2021). The Effects of Vitamin D Level on Bone Lesions and Prognostic Factors in Multiple Myeloma. Meandros Medical And Dental Journal, 22(2), 196 - 202. 10.4274/meandros.galenos.2021.94557 |
| Chicago | SİNCAN Gülden,ERDEM Fuat The Effects of Vitamin D Level on Bone Lesions and Prognostic Factors in Multiple Myeloma. Meandros Medical And Dental Journal 22, no.2 (2021): 196 - 202. 10.4274/meandros.galenos.2021.94557 |
| MLA | SİNCAN Gülden,ERDEM Fuat The Effects of Vitamin D Level on Bone Lesions and Prognostic Factors in Multiple Myeloma. Meandros Medical And Dental Journal, vol.22, no.2, 2021, ss.196 - 202. 10.4274/meandros.galenos.2021.94557 |
| AMA | SİNCAN G,ERDEM F The Effects of Vitamin D Level on Bone Lesions and Prognostic Factors in Multiple Myeloma. Meandros Medical And Dental Journal. 2021; 22(2): 196 - 202. 10.4274/meandros.galenos.2021.94557 |
| Vancouver | SİNCAN G,ERDEM F The Effects of Vitamin D Level on Bone Lesions and Prognostic Factors in Multiple Myeloma. Meandros Medical And Dental Journal. 2021; 22(2): 196 - 202. 10.4274/meandros.galenos.2021.94557 |
| IEEE | SİNCAN G,ERDEM F "The Effects of Vitamin D Level on Bone Lesions and Prognostic Factors in Multiple Myeloma." Meandros Medical And Dental Journal, 22, ss.196 - 202, 2021. 10.4274/meandros.galenos.2021.94557 |
| ISNAD | SİNCAN, Gülden - ERDEM, Fuat. "The Effects of Vitamin D Level on Bone Lesions and Prognostic Factors in Multiple Myeloma". Meandros Medical And Dental Journal 22/2 (2021), 196-202. https://doi.org/10.4274/meandros.galenos.2021.94557 |
