TY  - JOUR
TI  - The Effects of Vitamin D Level on Bone Lesions and Prognostic Factors in Multiple Myeloma
AB  - Objective: Several studies have found that low vitamin D levels are associatedwith an increased risk of hematologic malignancies and a poor prognosis. In thisstudy, we investigated the relationship between 25-hydroxyvitamin D levels andbone lesions as well as prognostic factors in patients with multiple myeloma.Materials and Methods: We evaluated 184 people who had just been diagnosedwith multiple myeloma. Complete blood count, biochemical parameters, serum25-hydroxyvitamin D [25(OH)D] level, presence of lytic bone lesion and fracture,and disease stage were all recorded. The patients were divided into three groupsbased on their 25(OH)D levels: deficient (<20 ng/mL), insufficient (20-29 ng/mL), and normal (≥30 ng/mL). SPSS-21 was used to perform statistical analyses.Results: The 25(OH)D was deficient in 121 patients (65.8%), insufficientin 28 patients (15.2%), and normal in 35 patients (19%). Age, presence oflytic bone lesion and bone fracture, plasma cell rate in bone marrow, andstage of disease (p=0.02; p=0.01; p=0.007; p=0.02, respectively) all differedsignificantly between these groups. Patients with normal 25(OH)D levelshad lower risk of lytic bone lesion and fracture. Furthermore, deficiencyand insufficiency of 25(OH)D had a negative impact on disease stage, andadvanced disease stage is a poor prognostic parameter for multiple myeloma.Conclusion: Patients with normal 25(OH)D levels have a lower risk of lytic bonelesion and vertebral fracture. The stage of the disease is influenced by 25(OH)Ddeficiency and insufficiency. Therefore, early detection and treatment of 25(OH)D deficiency and insufficiency in patients with multiple myeloma may reducemortality and morbidity rates.
AU  - SİNCAN, Gülden
AU  - ERDEM, Fuat
DO  - 10.4274/meandros.galenos.2021.94557
PY  - 2021
JO  - Meandros Medical And Dental Journal
VL  - 22
IS  - 2
SN  - 2149-9063
SP  - 196
EP  - 202
DB  - TRDizin
UR  - http://search/yayin/detay/459198
ER  -