Investigation of piwil2 expression as a biomarker in solidtumors of childhood
Yıl: 2021 Cilt: 28 Sayı: 8 Sayfa Aralığı: 1525 - 1531 Metin Dili: İngilizce DOI: 10.5455/annalsmedres.2020.09.976 İndeks Tarihi: 11-11-2021
Investigation of piwil2 expression as a biomarker in solidtumors of childhood
Öz: Aim: PIWIL 2 belongs to a subgroup of argonaute proteins, which has an essential role in germ cell development and repair. Recent studies have demonstrated PIWIL 2 as a stem cell marker in some solid tumors. In the present study, we aimed to evaluate the expression of PIWIL 2 in childhood solid tumors and to show being a potential marker for a therapeutic drug. Materials and Methods: The study included 150 patients who were diagnosed with pediatric solid tumor and followed between 2000 and 2011. Solid tumor preparations were stained with polyclonal PIWIL 2 antibody by using immunohistochemical methods. Results: Assessment of the tumor sub-groups showed that, among 30 patients with neuroblastoma, there was a strong staining in 5 (16.70%) (p=0.020). PIWIL 2 was showed strong staining in 3 (21.40%) osteosarcoma patients (p=0.030). Among 34 patients with a germ cell tumor, there was a strong staining in 6 (17.60%) patients (p=0.040). Conclusion: Significant PIWIL 2 positivity was found in neuroblastoma, osteosarcoma and germ cell tumors and it can be a potential marker for these tumors. Because of non-tumor tissue involvement in Wilms’ tumor it can be particularly useful in determining surgical margins.
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| APA | SEÇİLMİŞ Y, KARAKÜKÇÜ M, canöz ö (2021). Investigation of piwil2 expression as a biomarker in solidtumors of childhood. , 1525 - 1531. 10.5455/annalsmedres.2020.09.976 |
| Chicago | SEÇİLMİŞ YILMAZ,KARAKÜKÇÜ Musa,canöz özlem Investigation of piwil2 expression as a biomarker in solidtumors of childhood. (2021): 1525 - 1531. 10.5455/annalsmedres.2020.09.976 |
| MLA | SEÇİLMİŞ YILMAZ,KARAKÜKÇÜ Musa,canöz özlem Investigation of piwil2 expression as a biomarker in solidtumors of childhood. , 2021, ss.1525 - 1531. 10.5455/annalsmedres.2020.09.976 |
| AMA | SEÇİLMİŞ Y,KARAKÜKÇÜ M,canöz ö Investigation of piwil2 expression as a biomarker in solidtumors of childhood. . 2021; 1525 - 1531. 10.5455/annalsmedres.2020.09.976 |
| Vancouver | SEÇİLMİŞ Y,KARAKÜKÇÜ M,canöz ö Investigation of piwil2 expression as a biomarker in solidtumors of childhood. . 2021; 1525 - 1531. 10.5455/annalsmedres.2020.09.976 |
| IEEE | SEÇİLMİŞ Y,KARAKÜKÇÜ M,canöz ö "Investigation of piwil2 expression as a biomarker in solidtumors of childhood." , ss.1525 - 1531, 2021. 10.5455/annalsmedres.2020.09.976 |
| ISNAD | SEÇİLMİŞ, YILMAZ vd. "Investigation of piwil2 expression as a biomarker in solidtumors of childhood". (2021), 1525-1531. https://doi.org/10.5455/annalsmedres.2020.09.976 |
| APA | SEÇİLMİŞ Y, KARAKÜKÇÜ M, canöz ö (2021). Investigation of piwil2 expression as a biomarker in solidtumors of childhood. Annals of Medical Research, 28(8), 1525 - 1531. 10.5455/annalsmedres.2020.09.976 |
| Chicago | SEÇİLMİŞ YILMAZ,KARAKÜKÇÜ Musa,canöz özlem Investigation of piwil2 expression as a biomarker in solidtumors of childhood. Annals of Medical Research 28, no.8 (2021): 1525 - 1531. 10.5455/annalsmedres.2020.09.976 |
| MLA | SEÇİLMİŞ YILMAZ,KARAKÜKÇÜ Musa,canöz özlem Investigation of piwil2 expression as a biomarker in solidtumors of childhood. Annals of Medical Research, vol.28, no.8, 2021, ss.1525 - 1531. 10.5455/annalsmedres.2020.09.976 |
| AMA | SEÇİLMİŞ Y,KARAKÜKÇÜ M,canöz ö Investigation of piwil2 expression as a biomarker in solidtumors of childhood. Annals of Medical Research. 2021; 28(8): 1525 - 1531. 10.5455/annalsmedres.2020.09.976 |
| Vancouver | SEÇİLMİŞ Y,KARAKÜKÇÜ M,canöz ö Investigation of piwil2 expression as a biomarker in solidtumors of childhood. Annals of Medical Research. 2021; 28(8): 1525 - 1531. 10.5455/annalsmedres.2020.09.976 |
| IEEE | SEÇİLMİŞ Y,KARAKÜKÇÜ M,canöz ö "Investigation of piwil2 expression as a biomarker in solidtumors of childhood." Annals of Medical Research, 28, ss.1525 - 1531, 2021. 10.5455/annalsmedres.2020.09.976 |
| ISNAD | SEÇİLMİŞ, YILMAZ vd. "Investigation of piwil2 expression as a biomarker in solidtumors of childhood". Annals of Medical Research 28/8 (2021), 1525-1531. https://doi.org/10.5455/annalsmedres.2020.09.976 |
